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General control nonderepressible 2 (GCN2) is a serine/threonine-protein kinase that plays a key role in modulating amino acid metabolism as a response to nutrient deprivation. GCN2 is one of the four known sensors of the integrated stress response (ISR), which is a cytoprotective response mediated by eIF2α. Under conditions of amino acid deprivation, GCN2 inactivates eIF2α by phosphorylation, and eIF2α phosphorylation can also lead to enhanced transcription of mRNA molecules involved in host response to infection and inflammation. GCN2 is associated with cancer.
The AlphaLISA SureFire UltraHuman Phospho-GCN2 (Thr899) assay is a sandwich immunoassay for the quantitative detection of phospho-GCN2 (Thr899) in cellular lysates, using Alpha Technology.
|Experimental Type||In vitro|
|Product Brand Name||AlphaLISA SureFire Ultra|
|Shipping Condition||Blue Ice|
|Unit Size||100 Assay Points|
The introduction of enzyme-linked immunosorbent assays (ELISAs) in the early 1970’s offered researchers a non-radiometric immunoassay platform without compromising sensitivity. Over the last 50 years scientists have made huge strides in disease research and drug discovery and a demand for greater ...
Product brochure for the Alpha Technology, a versatile, no wash, homogeneous assay technology that's suitable for a broad range of applications.
Find out about our range of integrated solutions for drug discovery screening in this e-brochure.
Our screening solutions for high-throughput screening, phenotypic screening and data analysis help to streamline drug discovery workflows in labs across the globe. Our portfolio includes automat ...