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Fms related receptor tyrosine kinase 3 (FLT3) is a member of the class III receptor kinase family. FLT3 acts as a cell surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation, and survival of hematopoietic progenitor cells and of dendritic cells. This kinase is involved in the activation of the downstream effort of MTOR, promotes activation of RAS signaling, and phosphorylates downstream kinases including MAPK1/ERK2 and/or MAPK3/ERK1. Mutations of the FLT3 gene occur in approximately 30% of all acute myeloid leukemia cases.
The AlphaLISA SureFire Human Phospho-FLT3 (Tyr591) Detection Kit is a sandwich immunoassay for the quantitative detection of phospho-FLT3 (Tyr591) in cellular lysates, using Alpha Technology.
|Assay Points (200-50,000)||100 Assay Points|
|Experimental Type||In vitro|
|Product Brand Name||AlphaLISA SureFire Ultra|
|Shipping Condition||Blue Ice|
|Unit Size||100 Assay Points|
The introduction of enzyme-linked immunosorbent assays (ELISAs) in the early 1970’s offered researchers a non-radiometric immunoassay platform without compromising sensitivity. Over the last 50 years scientists have made huge strides in disease research and drug discovery and a demand for greater ...
Product brochure for the Alpha Technology, a versatile, no wash, homogeneous assay technology that's suitable for a broad range of applications.
Find out about our range of integrated solutions for drug discovery screening in this e-brochure.
Our screening solutions for high-throughput screening, phenotypic screening and data analysis help to streamline drug discovery workflows in labs across the globe. Our portfolio includes automat ...