PerkinElmer
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AlphaLISA SureFire Ultra Human Total DNA PKcs Detection Kit, 500 Assay Points

The AlphaLISA® SureFire® Ultra Human Total DNA PKcs assay is a sandwich immunoassay for quantitative detection of total DNA PKcs in cellular lysates using Alpha Technology.

For research use only; not for diagnostic procedures. All products to be used in accordance with applicable laws and regulations including without limitation, consumption & disposal requirements under European REACH regulations (EC 1907/2006).

Part Number
Unit Size
List Price
Your Price
Quantity
ALSU-TDNA-A500
500 Assay Points
1976.00 USD
 
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ALSU-TDNA-A10K
10,000 Assay Points
12100.00 USD
 
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ALSU-TDNA-A50K
50,000 Assay Points
38900.00 USD
 
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ALSU-TDNA-A-HV
100 Assay Points
587.00 USD
 
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Overview

DNA-PK, a nuclear DNA-dependent serine/threonine protein kinase, consists of two components, a DNA-dependent protein kinase, catalytic subunit (DNA PKcs) and an autoimmune antigen (KU). DNA-PKcs is inactive and relies on KU to direct it to DNA ends and trigger kinase activity where it is required for the non-homologous end joining pathway of DNA repair which rejoins double-strand breaks. DNA repair genes likely underlie many forms of cancer, and reduced expression of DNA PKcs is associated with cancers such as breast, prostate, and gastric.

The AlphaLISA SureFire Human Total DNA PKcs Detection Kit is a sandwich immunoassay for the quantitative detection of total DNA PKcs in cellular lysates, using Alpha Technology.

Formats

  • The HV (high volume) kit contains reagents to run 100 wells in 96-well format, using a 60 μL reaction volume.
  • The 500-point kit contains enough reagents to run 500 wells in 384-well format, using a 20 μL reaction volume.
  • The 10,000-point kit contains enough reagents to run 10,000 wells in 384-well format, using a 20 μL reaction volume.
  • The 50,000-point kit contains enough reagents to run 50,000 wells in 384-well format, using a 20 μL reaction volume.

AlphaLISA SureFire Ultra kits are compatible with

  • Cell and tissue lysates
  • Antibody modulators
  • Biotherapeutic antibodies

Alpha SureFire kits can be used for

  • Cellular kinase assays
  • Receptor activation studies
  • Screening

Specifications

Assay Points (200-50,000) 500 Assay Points
Assay Target DNA PKcs
Assay Technology Alpha
Automation Compatible Yes
Detection Method Alpha
Experimental Type In vitro
Product Brand Name AlphaLISA SureFire Ultra
Shipping Condition Blue Ice
Target Species Human
Therapeutic Area Oncology
Unit Size 500 Assay Points