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Cyclin-dependent kinase 7 (CDK7), or cell division protein kinase 7, is encoded by the CDK7 gene which is a member of the CDK family. CDK7 has dual functions, as a CDK–activating kinase (CAK) that regulates cell cycle progression by phosphorylation of CDK1, CDK2, and CDK4/6, and as a component of transcription factor II H (TFIIH) that regulates transcriptional initiation through phosphorylation of RNA polymerase II C-terminal domain. Inhibition of CDK7 offers an opportunity for restoring controlled cell cycle through regulating multiple cell cycle checkpoints, making it a cancer therapy target.
The AlphaLISA SureFire Human Total CDK7 Detection Kit is a sandwich immunoassay for the quantitative detection of total CDK7 in cellular lysates, using Alpha Technology.
|Assay Points (200-50,000)||50000 Assay Points|
|Experimental Type||In vitro|
|Product Brand Name||AlphaLISA SureFire Ultra|
|Shipping Condition||Blue Ice|
|Unit Size||50,000 Assay Points|
The introduction of enzyme-linked immunosorbent assays (ELISAs) in the early 1970’s offered researchers a non-radiometric immunoassay platform without compromising sensitivity. Over the last 50 years scientists have made huge strides in disease research and drug discovery and a demand for greater ...
Product brochure for the Alpha Technology, a versatile, no wash, homogeneous assay technology that's suitable for a broad range of applications.
Find out about our range of integrated solutions for drug discovery screening in this e-brochure.
Our screening solutions for high-throughput screening, phenotypic screening and data analysis help to streamline drug discovery workflows in labs across the globe. Our portfolio includes automat ...