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Catenin beta-1 (β-catenin) is a protein that is coded by the CTNNB1 gene. The Wnt/β-Catenin signaling pathway is crucial to regulating cell proliferation and polarity, cell determination, and tissue homeostasis. In the absence of extracellular WNT ligands, cytosolic β-Catenin is phosphorylated, thereby targeting the protein for ubiquitination, degradation, and inactivation. β-Catenin is implicated in various cancers and neurological diseases, such as salivary gland tumors, oral squamous cell carcinomas, Alzheimer’s disease, and Parkinson’s disease.
The AlphaLISA SureFire Ultra Human and Mouse Total ß-Catenin assay is a sandwich immunoassay for the quantitative detection of total ß-catenin in cellular lysates, using Alpha Technology.
|Experimental Type||In vitro|
|Product Brand Name||AlphaLISA SureFire Ultra|
|Shipping Condition||Blue Ice|
|Target Species||Human, Mouse|
|Therapeutic Area||Central Nervous System, Oncology|
|Unit Size||10,000 Assay Points|
The introduction of enzyme-linked immunosorbent assays (ELISAs) in the early 1970’s offered researchers a non-radiometric immunoassay platform without compromising sensitivity. Over the last 50 years scientists have made huge strides in disease research and drug discovery and a demand for greater ...
Product brochure for the Alpha Technology, a versatile, no wash, homogeneous assay technology that's suitable for a broad range of applications.
Find out about our range of integrated solutions for drug discovery screening in this e-brochure.
Our screening solutions for high-throughput screening, phenotypic screening and data analysis help to streamline drug discovery workflows in labs across the globe. Our portfolio includes automat ...