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BRD9 (Bromodomain-containing protein 9) is closely related to Bromodomain-containing protein 7 (BRD7), both of which are members of the Bromodomain-containing Proteins Family IV. BRD9 binds acetylated lysine residues of histones, mediating chromatin remodeling and regulating transcription and is therefore involved in pluripotency regulation and cell development. BRD9 overexpression is associated with neurodevelopmental disorders and cancers, such as acute myeloid leukemia. Targeting BRD9 degradation with PROTAC molecules has emerged as a novel therapeutic approach. Since BRD9 and BRD7 proteins share 72% residue similarity, compounds are likely to target both the pro-oncogene BRD9 and the tumor suppressor BRD7, suggesting that selectivity of compounds targeting either BRD9 or BRD7 must be carefully investigated.
The AlphaLISA SureFire Human and Mouse Total BRD9 Detection Kit is a sandwich immunoassay for the quantitative detection of total BRD9 in cellular lysates, using Alpha Technology.
|Assay Points (200-50,000)||10000 Assay Points|
|Experimental Type||In vitro|
|Product Brand Name||AlphaLISA SureFire Ultra|
|Shipping Condition||Blue Ice|
|Target Species||Human, Mouse|
|Unit Size||10,000 Assay Points|
The introduction of enzyme-linked immunosorbent assays (ELISAs) in the early 1970’s offered researchers a non-radiometric immunoassay platform without compromising sensitivity. Over the last 50 years scientists have made huge strides in disease research and drug discovery and a demand for greater ...
Product brochure for the Alpha Technology, a versatile, no wash, homogeneous assay technology that's suitable for a broad range of applications.
Find out about our range of integrated solutions for drug discovery screening in this e-brochure.
Our screening solutions for high-throughput screening, phenotypic screening and data analysis help to streamline drug discovery workflows in labs across the globe. Our portfolio includes automat ...