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Beclin-1 (BECN1) plays a central role in the regulation of autophagy and cell death. Together with PI3KC3, Beclin-1 nucleates autophagosome formation and is essential for proper degradation of cellular components. The activity of Beclin-1 is impacted by many factors, especially different binding partners. Numerous membranic, cytosolic, and nuclear proteins have been identified as activators of autophagy by binding to Beclin-1. Improper Beclin-1 signaling is associated with cancer, neurodegenerative diseases, and cardiac dysfunction.
The AlphaLISA SureFire Ultra Total Beclin-1 assay is a sandwich immunoassay for the quantitative detection of total Beclin-1 in cellular lysates, using Alpha Technology.
AlphaLISA SureFire Ultra kits are compatible with:
Alpha SureFire kits can be used for:
|Experimental Type||In vitro|
|Product Brand Name||AlphaLISA SureFire Ultra|
|Shipping Condition||Blue Ice|
|Therapeutic Area||Cardiovascular, Oncology|
|Unit Size||500 Assay Points|
The introduction of enzyme-linked immunosorbent assays (ELISAs) in the early 1970’s offered researchers a non-radiometric immunoassay platform without compromising sensitivity. Over the last 50 years scientists have made huge strides in disease research and drug discovery and a demand for greater ...
Product brochure for the Alpha Technology, a versatile, no wash, homogeneous assay technology that's suitable for a broad range of applications.
Find out about our range of integrated solutions for drug discovery screening in this e-brochure.
Our screening solutions for high-throughput screening, phenotypic screening and data analysis help to streamline drug discovery workflows in labs across the globe. Our portfolio includes automat ...