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α-Bungarotoxin is an antagonist that binds irreversibly at nicotinic acetylcholine receptors. These receptors respond to neurotransmitters and are found in the central and peripheral nervous system, muscle and other tissues and are involved in muscle contraction. Nicotinic acetylcholine receptors have been identified as potential drug targets for Alzheimer's disease, schizophrenia, ADHD, and nicotine addiction.
We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.
Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.
References for NET1170:
|Fresh Lot Days||Second Monday in February and August|
|Label Position||Specifically Labeled|
|Product Brand Name||NEN Radiochemicals|
|Shipping Condition||Dry Ice|
|Special Ordering Information||This is a radioactive product - shipping address must have a license to receive radioactive materials.|
|Therapeutic Area||CNS & Neurologic|
|Unit Size||50 µCi|