Cellular Thermal Shift Assays - Bringing Relevant Target Engagement to your Drug Discovery Workflow


The Cellular Thermal Shift Assay (CETSA®, by Pelago Bioscience) is an easy and proven method to demonstrate ligand-protein interactions in living cells and can be used without the need of any modifications to the ligand or protein. Quantification methods like PerkinElmer’s no-wash immunoassays Alpha or Homogenous Time Resolved Fluorescence (HTRF®) can be subsequently applied to confirm biologically relevant findings.

Watch this webinar to:

  • Learn from case studies: how industry leaders apply CETSA® to gain clarity in complexity earlier by generating physiologically relevant target engagement data.
  • Understand the big picture and listen to pharma thought leaders on how they view CETSA® and its impact on their drug discovery.


Joseph Shaw
Associated Principal Scientist
AstraZeneca, Cambridge/UK


Ruth Sommese
Principal Scientist and Cell Sciences Lab Head

Ken Comess, PhD
Principal Research Scientist II