HCS for Predictive Toxicology and in vitro Pathology Using Simple 3D Microtissues


This webinar will describe the integration of biology and engineering to devise simple, high-throughput 3D human microtissues as predictive biology platforms that reflect human physiology and disease, solving fundamental questions of adverse biological response with the goal of modernizing toxicity and drug candidate testing.

Learn about: the tension between assay simplicity and biological complexity in designing 3D microtissues; development of a human breast cancer MCF-7 3D microtissue model as an initial example of the approach; the application of "in vitro pathology" in quantifying the effects of estrogenic exposures in the MCF-7 3D microtissue model; the challenges and opportunities that arise with primary cells, co-cultures, and induced pluripotent stem cells.