3D High-Content Screening of Organoids for Drug Discovery


  • This webinar, presented by Daniel V. LaBarbera, Associate Professor of Drug Discovery and Medicinal Chemistry, University of Colorado, will describe the marriage of 3D organoids and high-content screening (HCS) to discover targeted drug therapies effective against the malignant phenotype in colorectal cancer (CRC).

    He will also describe a robust methodology for automated tumor organoid culture and validated 3D high-content analysis algorithms, which have been used to screen a focused library of 3,000 small molecule compounds and have identified and validated hits that promote the reversion of epithelial-mesenchymal transition (EMT) in CRC.