PerkinElmer
Gene Editing of Primary Immune Cells

White Paper

Gene Editing of Primary Immune Cells to Aid Next-Generation Cellular Immunotherapies

Gene Editing of Primary Immune Cells

Introduction

Our current understanding of the pathways leading to cytokine production in humans originates from studies in transformed T-cell lines, which do not accurately recapitulate primary human cell biology. This whitepaper describes how loss- and gain-of function studies with primary human T cells offer critical insights into the pathways required for cytokine regulation.