A Guide to CHO HCPs in Biopharmaceutical Manufacturing


During the production process of recombinant proteins, the host organisms - most of the time Chinese Hamster Ovary cells (CHO) - also produce endogenous proteins that are called Host Cell Proteins (HCPs). In the biopharmaceutical manufacturing industry, removing these impurities to meet regulatory requirements is one of the biggest and most costly challenges.

In this Guide, discover the latest strategies and tools to quantify CHO HCPs and their benefits compared to the ELISA standard approach.


  • A summary of the global biopharmaceutical landscape, including market studies and manufacturing processes
  • A description of the assays’ principles for CHO HCP detection, featuring a comparison of their technological features
  • A presentation of AlphaLISA and HTRF immunoassays, the first automatable and no-wash format kits for CHO HCP detection