PerkinElmer
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Application Note

Label-Free Analysis of Cardiomyocyte Beating using the Opera Phenix Plus System

Introduction

Drug-induced cardiotoxicity is a frequent cause of drug attrition during drug development and can lead to the withdrawal of drugs from the market, so non-invasive approaches that allow quick and reliable assessment of the cardiotoxic potential of a compound are key to improve drug safety.

In this application note, learn how the Opera Phenix® Plus high-content screening system together with the MuviCyte live-cell imaging system can be used for:

  • Reliable quantification of cardiomyocyte beating frequency
  • Fast frame rate imaging up to 100 fps to accurately capture fast cellular responses
  • Tip-based on-board pipetting compatible with 96 and 384-well plates
  • Stable environmental conditions with temperature, CO2, and humidity control