Quantitative Assessment of Compliance and Resistance in Emphysema Mouse Model Using MicroCT



Emphysema is a form of chronic obstructive pulmonary disease (COPD) most often association with smoking. It is a leading cause of death worldwide and is characterized by irreversible and severe destruction of the alveolar lung sacs. Small animal models are critical to understanding lung disease, however despite the severe morphological changes within the lung, imaging in small animal models can be challenging.

View this poster, presented at the 19th Fraunhofer Seminar "Models of Lung Disease“ in Hannover, Germany, where scientists from Boehringer Ingelheim and PerkinElmer developed a method using the Quantum microCT imaging system for rapid assessment of lung compliance and resistance in an emphysema mouse model. When used in conjunction with a small animal ventilator this methodology can be used as a non-destructive and cost-effective tool for rapid and longitudinal assessment of pathophysiological changes in the lung. This method can be further extended towards characterization of other models of lung disease and for evaluation of novel preventive and therapeutic strategies.