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Integrins as targets for Immunotherapy

Introduction

Integrins are a superfamily of transmembrane cell surface receptors that mediate signal transduction, cell-to-cell interaction, and cell-to-extracellular matrix adhesion - key processes for healthy cells as well as in the progression of disease states such as cancer.

Among this superfamily, αvβ3 integrin holds promise as a therapeutic target in areas such as immuno-oncology, where it may enable tumors to evade the immune system. PerkinElmer's IntegriSense fluorescent probes are designed to target αvβ3 integrin to help researchers better understand how cancer cells hijack normal integrin-related cell signaling and cell adhesion processes that promote tumor growth and metastases, as well as investigating the potential of integrin-blocking cancer immunotherapies.