PerkinElmer
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Case Study

B Cell Selection and Therapeutic Antibody Characterization Using the Operetta High Content Imaging System

Introduction

This case study illustrates how PerkinElmer’s high-content imaging solutions are enabling therapeutic antibody development. Two steps in the workflow - the clonal B cell selection and the functional antibody characterization - rely on high-content screening using the Operetta® system.

The coupling of the Operetta system to a plate::handler workstation allows the running of plates both day and night, further increasing the throughput. In addition, the EnVision multimode plate reader and the JANUS Automated Workstation are essential parts of the workflow that contribute to the throughput of the process and reduce the variability of liquid handling steps.