PerkinElmer
894635270_1920.jpg

Case Study

A Novel Mouse Model Using Optical Imaging to Detect On-Target, Off-Tumor CART-T Cell Toxicity

Introduction

CAR T therapy has achieved tremendous success in treating blood malignancies, however treating solid tumors with CAR T cells has proven to be challenging due to several factors such as on-tumor, off-tumor toxicity.

Read this case study where researchers from University of Pennsylvania created a mouse model that expresses tumor associated antigens in normal tissue to study off-tumor CART-T cell toxicity. These studies used optical imaging on the IVIS® platform to longitudinally monitor off-tumor antigen expression, tumor progression, and CAR-T cell trafficking in live animals.