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Article

Inhibiting Interleukin 11 Signaling Reduces and Reverses Many Dangerous Effects of NAFLD/NASH in Mouse Models

Introduction

Accumulation of fat in liver cells, a process called steatosis, is a common health problem that has many possible causes. Nonalcoholic fatty liver disease (NAFLD) is a group of conditions caused by the buildup of fat in the liver, with some sources estimating that one in four people develop it in their lifetime. NAFLD, if left untreated, may progress to nonalcoholic steatohepatitis (NASH). Dr. Anissa A. Widjaja and colleagues recently examined the connection between interleukin 11 (IL-11) signaling and the development of liver disease.