Scientists around the world have been working at warp speed to find the best ways to treat and prevent SARS-CoV-2 infection. In contrast to rapid development of effective vaccines, treatments for COVID-19 remain somewhat elusive. Multiple approaches to identify potential therapeutics targeting SARS-CoV-2 infections are currently being pursued. Most of the treatments fall into one of three categories: antivirals, antibodies, or protein-protein interaction inhibitors. In the following literature review, we have highlighted the various approaches that researchers have adopted to identify potential new therapeutics and the challenges they face when it comes to the latest variants.