Application Note

The Determination of Lead in Calcium-Based Antacid and Dietary Supplements Using the NexION 350 ICP-MS System to Comply with the State of California's Proposition 65 Legislation


Compliance with California’s Proposition 65 for the monitoring of lead (Pb) in calcium-based antacid medications and dietary supplements requires the analytical methodology to demonstrate detection limits below 0.05 µg/g in the solid material. The analytical capabilities of Inductively Coupled Plasma Mass Spectrometry (ICP-MS) make it the most suitable technique for performing lead determinations at these low levels on a routine basis.