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Application Note

Better Characterization of Water in Pharmaceuticals Using the Pyris 1 TGA Accupik Accessory

Introduction

One important aspect associated with many pharmaceutical materials is the water content. Moisture, in the form of free water or hydrate(s) (chemically bound) will affect the properties of the pharmaceutical material including: thermal stabilities, shelf life, plasticizing effects on the glass transition event (Tg), sticking and clumpiness, and the rate of dissolution.