We offer NIR Fluorescent imaging reagents that fall into three different categories:
Activatable probes are optically silent upon injection but are activated in vivo through cleavage by specific protease biomarkers of disease. Benefits include biologically specific readouts and high signal-to-noise at the target biology. The FAST platform represents the next generation of agents. Using a novel small molecule design, the FAST agents offer improved specificity, accelerated activation profiles and earlier imaging timepoints.
IVISense Cat B FAST
Fluorescent imaging probe for selective imaging of cathepsin B proteinases (Cat B). Optically silent in the unactivated state, becoming highly fluorescent when activated.
IVISense Cat K FAST
Fluorescent probe for imaging of cathepsin K in oncology applications involving metastasis to the bone as well as a broad range of bone applications including bone loss, tumor-induced osteolyis and bone changes following arthritis.
IVISense MMP and IVISense MMP FAST
Fluorescent probe for imaging of MMP (metalloproteinase) activity, which is involved involved in many disease-related phenomena including cancer propagation, invasion and metastasis, rheumatoid arthritis and areas of cardiovascular disease.
IVISense Neutrophil Elastase FAST
Fluorescent neutrophil elastase-activatable probe that is optically silent upon injection and produces fluorescent signal after cleavage by elastase produced by neutrophil cells.
IVISense Pan Cathepsin & IVISense Pan Cathepsin FAST
Versatile imaging of changes in cathepsin-based protease activity as seen in a number of pathological states and disease-related events including rheumatoid arthritis, cancer, atherosclerosis, angiogenesis and cardiovascular disease.
IVISense Renin FAST
Fluorescent probe for imaging of renin-angiotensin pathway associated with hypertension, kidney and cardiovascular disease.
Targeted Probes
Targeted probes bind to specific biomarkers within the cell or animal: cell membrane constituents such as lipids, receptors, glycoproteins, etc. The use of targeted probes in preclinical imaging allows for highly specific targeting of particular biologies.
IVISense 2-DG
NIR targeted probe for non-invasive imaging of glucose uptake of tumors in vivo.
IVISense Annexin-V
In vivo targeting of membrane-bound phosphatidylserine exposed during the early stages of apoptosis.
IVISense Bacterial Fluorescent Probe
NIR targeted probe for non-invasive detection of bacterial infections in vivo.
IVISense Bombesin Receptor
NIR targeted probe specific to bombesin receptors, which are expressed in many types of cancers.
IVISense Folate Receptor
Highly specific and sensitive in detection of Folate Receptor protein. Can be used to closely monitor and quantitate tumor growth and metabolism.
IVISense GFR
Near infrared (NIR) fluorescent-labeled form of inulin. Enables assessment of Glomerular filtration rate (GFR) by measurement of the rate of disappearance of labeled inulin from the blood.
IVISense Hypoxia CA IX
Fluorescent imaging probe that detects the tumor cell surface expression of carbonic anhydrase 9 (CA IX) protein, which increases in hypoxic regions within many tumors, especially in cervical, colorectal, non-small cell lung tumors.
IVISense Integrin Receptor
Potent antagonist targeting integrin αγβ3, expressed in oncology, atherosclerosis and angiogensis disease models. Small molecule fluorochrome to label target ligand.
IVISense Osteo
Fluorescent in vivo bisphosphonate imaging probe that targets areas of micro-calcifications and bone remodeling and enables imaging of bone growth and resorption.
IVISense Tomato Lectin
Near-infrared dye-labeled macromolecule that targets the vasculature and enables imaging of blood vessels and angiogenesis.
IVISense Transferrin Receptor
Near infrared (NIR) targeted fluorescent imaging probe consisting of recombinant transferrin conjugated to VivoTag dye, designed to bind to transferrin receptors expressed in cancer cells.
Vascular/Physiologic Probes
Vascular and physiologic probes are a range of highly fluorescent in vivo imaging molecules that remain highly stable and localized in the anatomy for various periods of time to enable imaging of disease physiology, vasculature, vascular permeability and angiogenesis.
IVISense Vascular
Near-infrared dye-labeled macromolecule for imaging of vascularity, perfusion and vascular permeability. Remains localized in vasculature for 0-4 hours and accumulates in tumors and arthritic joints at 24 hours.
IVISense Vascular NP
Near-infrared dye-labeled nanopaticles for imaging of vascularity, perfusion and vascular permeability with a long pharmacokinetic profile.
IVISense Gastrointestinal
Near-infrared, fluorescently-labeled macromolecule that may be used to monitor the effects of disease or drugs on gastric motility and or gastric emptying. It may also be used as an anatomical marker for the gastrointestinal tract.
IVISense Acute Vascular
This is a small molecule fluorescence probe and is used as a control or in vascular permeability imaging.
IVISense Edema
Small molecule fluorescence probe for imaging of vascularity, perfusion and vascular permeability with a short pharmacokinetic profile. This agent binds to albumin in blood for extended (30m-1h) circulation.