PerkinElmer

Viral Research Solutions

The discovery of antivirals and vaccines has revolutionized medicine and saved billions of children from diseases such as polio and smallpox. However, high mutation rates and the existence of animal reservoirs are contributing to the emergence of new pathogenic viruses with epidemic or pandemic potential, which was demonstrated by the COVID-19 outbreak as a result of the novel human coronavirus SARS-CoV-2. Simply put, we’re far from fully understanding or entirely controlling viral diseases and their outbreaks.

That’s why understanding viral diseases and translating research findings into more effective vaccines and treatments are at the core of what we do.

Virus Genomics

Viral genomes exhibit enormous diversity in their makeup: the majority are based on RNA, although DNA-based viral nucleic acids are not uncommon. Viral genomes can be linear, circular, or segmented; single-stranded or double-stranded; positive-sense or negative-sense. Furthermore, many viruses have high rates of mutation, such as point mutations, recombinations, or segment reassortments, which can render them resistant to antiviral treatments – or result in a new, more virulent strain if a major genetic change is involved.

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Virus Detection and Drug Discovery

Discovery of new antiviral therapies is critical for global human health, particularly due to the speed that new viruses such as SARS-CoV-2 or influenza viruses can emerge. Standard drug discovery pipelines can take over a decade to deliver a product to market. One way to accelerate development, especially in times of high unmet medical crises such as COVID-19, is to repurpose existing drugs. Whether it’s for drug repurposing or discovery, detecting viruses in cell cultures and quantifying viral replication reliably are critical to fighting existing or emerging viruses.

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Host Virus Interactions

Viruses replicate through host cells and interact with many different proteins. These protein-protein interactions (PPIs), known as the virus-host interactome, can be targeted with therapeutic drugs to inhibit viral infection or subsequent replication. Developing inhibitors against the virus-host interactome by targeting cellular proteins is a promising approach to circumvent the possible emergence of drug-resistant virus mutants, as cellular proteins have much lower intrinsic mutation rates than viral proteins. Another approach to reduce viral escape mutants is to develop antibody cocktails, a mix of neutralizing antibodies that target different epitopes on viral surface proteins.

Immune Response and Vaccines

The innate immune system is the body’s first line of defense against viral disease. Different cell types protect the host from infection by foreign agents in a nonspecific manner. If a pathogen overcomes this defense, the adaptive immune system is activated to produce antibodies and confer a long-lasting resistance. Neutralizing antibodies that prevent a pathogen from binding to its host cell receptor play a major role in fighting viral infections and are often the desired outcome of vaccination.

Explore Our Viral Disease Research Instruments and Solutions

High Content Screening Instruments & Microscopes

Get the sensitivity and throughput you need to image more samples and analyze more parameters with high content screening. Our high content screening instrument ...

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Live-cell Imaging Systems

Life science research labs study cellular behaviors and pathways to gain a deeper understanding of functions, disease mechanisms and responses to treatments. An ...

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In Vivo Imaging Instruments

Seamlessly monitor both functional and anatomical attributes of disease, decreasing both the time and cost of your experiments. Our best-in-class instruments fa ...

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Virology Reagents

Viruses and virally transmitted diseases have been impacting human health and well-being for millennia. Some of our greatest scientific challenges and medical t ...

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Microplate Readers

Performance, Versatility, and Reliability for Today’s Laboratory Needs As many of you know, microplate readers are instruments used to detect biological, chemic ...

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Laboratory Services

Today’s scientific lab leaders are facing new pressures and demands to continue to innovate while looking for more lab productivity. With tighter deadlines, inc ...

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