VesselVue Microbubble Contrast Agents

Visualize microvasculature like never before

PerkinElmer’s VesselVue® microbubble contrast agents are lipid encapsulated micron-sized particles with a gas core that are injected intravenously into the animal. These agents are non-toxic to the animal, and with each microbubble being smaller than a red blood cell, circulate systemically and clear the body in minutes.

Contrast-enhanced ultrasound (CEUS) is a technique that uses microbubble-based contrast agents to improve the echogenicity of blood which in turn enhances and aids in the visualization of vessels and tissue vascularity.

VesselVue microbubble contrast agents can be used to study tissue perfusion and blood flow characteristics on ultrasound systems equipped with CEUS imaging modes. Using VesselVue in combination with PerkinElmer’s exclusive Acoustic Angiography mode on the Vega® ultrasound system, a unique form of CEUS imaging, researchers can obtain high resolution images of microvessel density and morphology, which are biomarkers useful for studying angiogenesis and vascular bed development.

Available in USA and Canada only For research use only. Not for use in diagnostic procedures.

VesselVue microbubble contrast agents are available in multiple formulations to suit your application

P formulation

P-formulation (polydisperse) for acoustic angiography and general imaging applications
- Wider size distribution
- Smaller mean diameter

S formulation

S-formulation (size selected) provides improved signal sensitivity for specific applications such as molecular imaging
- Narrower size distribution
- Larger mean diameter

Structure of VesselVue Microbubble Contrast Agents

Activation only required for VesselVue P-formulation. S-formulation does not require activation as this product is shipped already activated.

cell workflow infographic

(Left) Activation of VesselVue P-formulation microbubble contrast agents pre and post mechanical agitation using a VesselVue Microbubble Mixer (sold separately). S-formulation does not require activation. (Right) Structure of microbubbles.

cell workflow infographic

Kidney (left) and Tumor (right) vascularity using VesselVue microbubble contrast agents and acoustic angiography using the Vega ultrasound imaging system.

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  • VesselVue Microbubble Contrast Agent S formation

    VesselVue Microbubble Contrast Agent, S-Formulation

    Size-isolated S-formulation VesselVue® microbubble contrast agent for contrast enhanced ultrasound (CEUS) has a diameter distribution of 4-5 µm and offers greater stability than other microbubbles of the same size. The tighter size distribution of this formulation allows for biologically targeted studies to be performed, while the larger microbubble size can achieve greater acoustic response enabling more sensitive ultrasound imaging.
    List Price : 609.00 USD
  • VesselVue Microbubble Contrast Agent P formation

    VesselVue Microbubble Contrast Agent, P-formulation

    VesselVue® P-formulation microbubble contrast agent designed for contrast enhanced ultrasound (CEUS), is a polydisperse diameter distribution that is ideal for a wide-range of vascular ultrasound imaging applications and exploratory studies.
    List Price : 505.00 USD
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