PerkinElmer

Receptor Ligand Binding

OF

A receptor ligand binding assay allows for the study and simple imaging of cell surface receptors for research and diagnostic applications. Receptor ligand binding is used in drug development applications to identify blocking antibodies or inhibitors that can modulate downstream signaling events, and is often used to screen for drugs that target hormone and neurotransmitter activity. We offer a range of tools for receptor ligand binding assays including radioligands, receptor-transfected cell membranes, and cell lines. Products available support both agonist and antagonist assays.

Our offerings include assays for:

  • Tyrosine kinase receptors
  • G-protein coupled receptors (GPCR)
  • Drug discovery and development
  • Ion channels
  • Protein analysis, detection, and interaction

Our collection of receptor ligand binding related assays includes fluorescence, LANCE® and DELFIA® time-resolved fluorescence, Alpha chemiluminescent assays, lites luminescence assays, and radiometric detection methods. Simplify the development of your assays and the calculation of your results using our radioligands, receptor-transfected cell membranes, and cell lines for receptor ligand binding applications.

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Assay points(200-50,000)
  • 500 (2)
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Coating Treatment
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Concentration
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Detection Method
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Format
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Radionuclide
  • 125I (78)
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Radioisotope
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Receptor Type
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"Receptor Ligand Binding" 1-50 of 548 Products and Services

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MICROBETA FILTERMAT-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the FilterMate Harvester. From beginning to end, the FilterMate system is easy to use.

OMNIFILTER-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the OmniFilter Harvester.

UNIFILTER-24 CELL HARVESTER

Speed and simplicity are the primary strengths of the Unifilter Harvester.

UNIFILTER-96 CELL HARVESTER SS

Speed and simplicity are the primary strengths of the Unifilter Harvester.
LabChip EZ Reader

EZ READER, SHIP LEVEL

The EZ Reader can help to save time and money in your laboratory by identifying the most promising lead candidates faster.

The EZ Reader instrument is available outside the EU. Please contact your local representative for further information.

UNIFILTER-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the Unifilter Harvester.

MICROBETA FILTERMAT-24 CELL HARVESTER

Speed and simplicity are the primary strengths of the FilterMate Harvester. From beginning to end, the FilterMate system is easy to use. Need additional information? Click on the tabs in the product details section below.

WIN 35428, [N-Methyl-3H]

WIN 35428 [(–)-2-β-Carbomethoxy-3-β-(4-fluorophenyl)tropane], tritiated on the N-methyl group. WIN 35428 acts as an antagonist at dopamine transporters (DATs).
Price Range : 705.00 USD - 5100.00 USD

Peptide YY, (Porcine), ([125I]-PYY)

Peptide YY (peptide tyrosine tyrosine), labeled with 125I. Peptide YY acts as a neuropeptide Y receptor Y2 agonist, is released in response to feeding, and is associated with appetite saiety.
Price Range : 1007.00 USD - 2326.00 USD
Receptor-expressing cell lines

ValiScreen Vasopressin V2 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
PerkinElmer

Membrane Target Systems: A9 cells membranes

Wild Type Subtype A9L (mouse) Control Membrane 10mg Frozen suspension cell membrane. Shipped on dry ice.
List Price : 557.00 USD

Neurokinin A, ([125I]-Substance K

Neurokinin A (Substance K), labeled with 125I. Neurokinin A is a member of the tachykinin family of neuropeptide neurotransmitters, and is an endogenous agonist for NK-2 receptors. NK-2 receptors are potential drug targets for depression.
Price Range : 818.00 USD - 1966.00 USD
PerkinElmer

Membrane Target Systems: Vasopressin V1b (human) membrane preparation, in 1321N1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 936.00 USD

2`-Deoxycytidine-5`-triphosphate, 5-[125I] iodo-, Tetraammonium Salt

Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that is used whenever DNA is synthesized, such as in the polymerase chain reaction. 125I dCTP may be used to produce cDNA transcripts of viral or mRNA.
Price Range : 1097.00 USD - 2742.00 USD
PerkinElmer

Streptavidin YSI 75MG

Streptavidin-coated SPA beads, for capturing biotinylated biomolecules in proximity-based radiometric scintillation assays.
List Price : 831.00 USD

Apamin [125I]His18-NH2

Apamin, labeled with 125I on histidine residue 18. Apamin is a neurotoxin that acts as an antagonist at calcium-activated potassium channels (SK channels).
Price Range : 910.00 USD - 1514.00 USD
Receptor-expressing cell lines

Neuropeptide FF NPFF1 ValiScreen Cell Line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.

Deltorphin II (2-D-Ala), [Tyrosyl-3,5-3H]

Deltorphin II, tritiated at the tyrosyl-3,5 position. Deltorphin II is a selective δ opioid receptor (DOPR) agonist.
Price Range : 913.00 USD - 3866.00 USD

LH-RH, [125I]-[D-Trp6]

Luteinizing Hormone Releasing Hormone (LHRH), labeled with 125I. LHRH binds LHRH receptors, and is a drug target for cancer therapy.
Price Range : 1047.00 USD - 2792.00 USD
Receptor-expressing cell lines

Melanin concentrating hormone (MCH1) receptor (human recombinant) AequoZen Frozen Cells

Our frozen, irradiated AequoZen cells express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light.
List Price : 765.00 USD
PerkinElmer

Select-a-Bead Kit 5 X 100 MG

SPA bead selection kit for receptor binding studies (contains 100 mg of WGA PVT, WGA Ysi, WGA PEI type A, WGA PEI type B, and Poly-L-lysine beads)
List Price : 818.00 USD

PACAP27, [125I]

Pituitary adenylate cyclase activating peptide-27 (PACAP-27), labeled with 125I. PACAP-27 binds the pituitary adenylate cyclase-activating polypeptide type I receptor (PAC1) and vasoactive intestinal peptide receptors (VPAC1 and VPAC2).
Price Range : 797.00 USD - 1670.00 USD

Ketanserin Hydrochloride (R41 468), [Ethylene-3H]

Ketanserin hydrochloride (Sufrexal; R41468), tritiated on the ethylene group. Ketanserin is a high-affinity non-selective antagonist of 5-HT2 receptors.
Price Range : 614.00 USD - 5500.00 USD

MESULERGINE, [N-METHYL-3H]-, 250 µCi

Mesulergine, tritiated on the N-methyl group. Mesulergine acts as an antagonist at serotonin 5-HT2A and 5-HT2C receptors, and as a partial agonist at dopamine receptors.
List Price : 1776.00 USD

Methylspiperone, [N-Methyl-3H]-, 250µCi (9.25MBq)

Methylspiperone radioligand tritiated at the N-Methyl position. Methylspiperone is an antagonist at the 5-HT2A receptor and a selective dopamine D2 antagonist.
List Price : 1994.00 USD

Vasopressin (Linear), V-1A Antagonist (Phenylacetyl1, 0-Me-D-Tyr2, [125I-Arg6]-)

Vasopressin (linear), labeled with 125I. Linear vasopressin acts as an antagonist at vasopressin receptor 1A (V1AR).
Price Range : 964.00 USD - 2140.00 USD

Apelin 13 [125I]

Apelin, labeled with 125 I. Apelin is the endogenous ligand for apelin receptors, and is used in receptor binding studies. Apelin 13 is a 13-amino acid peptide corresponding to residues 65-77.
Price Range : 998.00 USD - 3477.00 USD
Receptor-expressing cell lines

ValiScreen Serotonin 5HT-5A (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
PerkinElmer

Membrane Target Systems: Melanocortin MC4 (human) membrane preparation

Cell membranes prepared from cells stably-transfected with human Melanocortin MC4 receptor, in HEK-293 cells.
List Price : 936.00 USD
PerkinElmer

Membrane Target Systems: Neuromedin U NMU2 (human) membrane preparation

Cell membranes prepared from cells stably-transfected with human Neuromedin U NMU2 receptor, in HEK-293 cells.
List Price : 936.00 USD

TGF-β1 (human, recombinant), [125I]

Transforming growth factor beta 1 (TGF-β1), labeled with 125I. TGF-β1 is a cytokine that is involved in cell growth, cell differentiation, and apoptosis.
Price Range : 845.00 USD - 2117.00 USD

Dihydroxyphenylethylamine (Dopamine), 3,4-[Ring-2,5,6-3H]

Dihydroxyphenylethylamine (dopamine, DA), tritiated at the ring-2,5,6- position. Dihydroxyphenylethylamine is a neurotransmitter and is the primary endogenous ligand for dopamine receptors.
Price Range : 640.00 USD - 1485.00 USD

2'-deoxycytidine-5'-triphosphate, 5-[125I]Iodo-

Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that is used whenever DNA is synthesized, such as in the polymerase chain reaction. 125I dCTP may be used to produce cDNA transcripts of viral or mRNA.
List Price : 1746.00 USD
PerkinElmer

WGA PVT SPA 100 MG

WGA-coated SPA beads, for capturing cell membranes in proximity-based radiometric scintillation assays.
List Price : 182.00 USD
Receptor-expressing cell lines

ValiScreen Bradykinin B1 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
Receptor-expressing cell lines

ValiScreen Leukotriene BLT1 (LTB4R1) (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.

GR125743, [N-METHYL-3H]

GR125743, tritiated on the N-methyl group. GR125743 acts as an antagonist at serotonin 5-HT1B and 5-HT1D receptors.
List Price : 1810.00 USD

Somatostatin, [125I]Tyr11

Somatostatin, labeled with 125I. Somatostatin binds somatostatin receptors, and inhibits the secretion of insulin and glucagon.
Price Range : 904.00 USD - 2107.00 USD
PerkinElmer

Membrane Target Systems: Adenosine A3 (rat) membrane preparation

Cell membranes prepared from cells stably-transfected with rat Adenosine A3 receptor, in HEK-293 cells.
List Price : 936.00 USD
PerkinElmer

Protein A PVT 500 MG

Protein A-coated SPA beads, for capturing antibodies in proximity-based radiometric scintillation assays.
List Price : 831.00 USD

DOFETILIDE, [N-METHYL-3H], 100 µCi

Dofetilide, tritiated at the N-methyl position. Dofetilide is a selective potassium channel (hERG) blocker.
List Price : 1575.00 USD

GLP-1 (7-36), [125I]

Glucagon-like peptide-1 (GLP-1), labeled with 125I. GLP-1 is a peptide hormone involved in secretion of insulin, and binds and activates GLP-1 receptors, a member of the glucagon receptor family of GPCRs.
Price Range : 1219.00 USD - 2224.00 USD
PerkinElmer

ProfilerPro Kinase Selectivity Assay Plate Kit 4, for LabChip EZ Reader

Kit consist of matched pairs of 384-well kinase-assay and substrate plates. Each assay plate contains 24 different predispensed frozen kinases. Substrate plates contain the appropriate fluorescent labeled peptides and ATP.
List Price : 1559.00 USD

Motilin, [125I]

Motilin, labeled with 125I. Motilin is a peptide hormone that binds motilin receptors, and stimulates contraction of gut smooth muscle.
Price Range : 1153.00 USD - 2319.00 USD

Raclopride, [Methoxy-3H]

Raclopride, [Methoxy-3H]- will have fresh lot dates on the second Monday in March and September.
Price Range : 558.00 USD - 4457.00 USD
Receptor-expressing cell lines

ValiScreen Ghrelin (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.

Sauvagine, [125I]-Tyr0]

Sauvagine, labeled with 125I on the tyrosine 0 residue. Sauvagine is a neuropeptide that acts as an agonist at corticotropin-releasing factor receptors (CRF receptors) 1 and 2.
Price Range : 1041.00 USD - 2164.00 USD
Receptor-expressing cell lines

ValiScreen Prostanoid DP (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
PerkinElmer

Membrane Target Systems: Urotensin UR2 (GPR14) (mouse) membrane preparation

Cell membranes prepared from cells stably-transfected with human Urotensin UR2 (GPR14) receptor, in CHO-K1 cells.
List Price : 936.00 USD

Serine, D-[3H(G)]-, 250µCi (9.25MBq)

Tritiated D-Serine. D-Serine acts as an agonist at N-methyl-D-aspartate receptors (NMDA receptors).
List Price : 1981.00 USD

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