PerkinElmer

Receptor Ligand Binding

OF

A receptor ligand binding assay allows for the study and simple imaging of cell surface receptors for research and diagnostic applications. Receptor ligand binding is used in drug development applications to identify blocking antibodies or inhibitors that can modulate downstream signaling events, and is often used to screen for drugs that target hormone and neurotransmitter activity. We offer a range of tools for receptor ligand binding assays including radioligands, receptor-transfected cell membranes, and cell lines. Products available support both agonist and antagonist assays.

Our offerings include assays for:

  • Tyrosine kinase receptors
  • G-protein coupled receptors (GPCR)
  • Drug discovery and development
  • Ion channels
  • Protein analysis, detection, and interaction

Our collection of receptor ligand binding related assays includes fluorescence, LANCE® and DELFIA® time-resolved fluorescence, Alpha chemiluminescent assays, lites luminescence assays, and radiometric detection methods. Simplify the development of your assays and the calculation of your results using our radioligands, receptor-transfected cell membranes, and cell lines for receptor ligand binding applications.

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"Receptor Ligand Binding" 1-50 of 550 Products and Services

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MICROBETA FILTERMAT-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the FilterMate Harvester. From beginning to end, the FilterMate system is easy to use.
LabChip EZ Reader

EZ READER, SHIP LEVEL

The EZ Reader can help to save time and money in your laboratory by identifying the most promising lead candidates faster.

The EZ Reader instrument is available outside the EU. Please contact your local representative for further information.

UNIFILTER-96 CELL HARVESTER SS

Speed and simplicity are the primary strengths of the Unifilter Harvester.

UNIFILTER-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the Unifilter Harvester.

OMNIFILTER-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the OmniFilter Harvester.

UNIFILTER-24 CELL HARVESTER

Speed and simplicity are the primary strengths of the Unifilter Harvester.

MICROBETA FILTERMAT-24 CELL HARVESTER

Speed and simplicity are the primary strengths of the FilterMate Harvester. From beginning to end, the FilterMate system is easy to use. Need additional information? Click on the tabs in the product details section below.
PerkinElmer

ProfilerPro Kinase Peptide Substrate 5, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 5 for kinase assays (inhibiton, target discovery, lead optimization)
List Price : 721.00 USD
PerkinElmer

HDAC (Histone Deacylase) Substrate B, for LabChip EZ Reader

Fluorescently-labelled Substrate A peptide (Acetylated) for Epigenetic Assays (Enzyme inhibiton, target discovery, lead optimization)
List Price : 700.00 USD
PerkinElmer

ProfilerPro Kinase Peptide Substrate 1, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 1 for kinase assays (inhibiton, target discovery, lead optimization)
List Price : 721.00 USD
PerkinElmer

Streptavidin PS Imaging Beads 50 MG

Streptavidin-coated SPA beads, for capturing biotinylated molecules in proximity-based scintillation assays.
List Price : 145.00 USD

Human Growth Hormone, [125I]

Human growth hormone (HGH), labeled with 125I. Human growth hormone stimulates growth, cell reproduction and regeneration in animals. HGH functions to regulate body composition, fluid homeostasis, glucose and lipid metabolism, skeletal muscle and bone growth.
Price Range : 880.00 USD - 2359.00 USD
Receptor-expressing cell lines

ValiScreen Vasopressin V1a (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
Receptor-expressing cell lines

ValiScreen Neuropeptide S NPS (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
PerkinElmer

ProfilerPro Kinase Peptide Substrate 6, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 6 for kinase assays (inhibiton, target discovery, lead optimization)
List Price : 721.00 USD

R(+)7-HYDROXY DPAT, [3H], 250 µCi

Tritiated R(+)7-Hydroxy DPAT. 7-OH-DPAT acts as a selective agonist at the dopamine D3 receptor. It also has low affinity for serotonin receptors.
List Price : 3292.00 USD
PerkinElmer

Protein A PVT 500 MG

Protein A-coated SPA beads, for capturing antibodies in proximity-based radiometric scintillation assays.
List Price : 831.00 USD

PACAP27, [125I]

Pituitary adenylate cyclase activating peptide-27 (PACAP-27), labeled with 125I. PACAP-27 binds the pituitary adenylate cyclase-activating polypeptide type I receptor (PAC1) and vasoactive intestinal peptide receptors (VPAC1 and VPAC2).
Price Range : 797.00 USD - 1670.00 USD
Receptor-expressing cell lines

ValiScreen Bombesin BB2 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.

Chloramphenicol, [Ring-3,5-3H]

Chloramphenicol, tritiated at the ring-3,5 position. Chloramphenicol is a broad spectrum antibiotic that binds to a receptor site on the 50S subunit of the bacterial ribosome, inhibiting peptidyl transferase.
Price Range : 1884.00 USD - 4131.00 USD

Norepinephrine, Levo-[7-3H]

Levo-Norepinephrine, tritiated at the 7 position. Norepinephrine binds and activates adrenergic receptors, and is cleared by the norepinehprine transporter (NET).
Price Range : 1195.00 USD - 9100.00 USD

Human IgG-conjugated AlphaLISA Acceptor Beads

AlphaLISA® Acceptor beads conjugated to human IgG (whole). These beads are intended for use in homogenous Alpha assays to capture Fc receptors.
Price Range : 773.00 USD - 23500.00 USD
PerkinElmer

Membrane Target Systems: Serotonin 5HT1a (human) membrane preparation, in CHO-K1 cells. 400 Units.

Cell membranes prepared from cells stably-transfected with human serotonin 5HT1a receptor
List Price : 936.00 USD
PerkinElmer

LabChip Sipper Chip Coating Reagent 8 (2 ml), for EZ Reader

Coating reagent 8 (CR8) is a positively-charged additive that can be added to the separation buffer. It will bind the silanol groups of the glass channels in the LabChip multi-sipper chip (the glass is negatively-charged) to neutralize the charge.
List Price : 139.00 USD
PerkinElmer

Membrane Target Systems: Galanin Gal1 (human) membrane preparation, in HEK-293 cells. 400 Units.

Cell membranes prepared from HEK293 cells stably-transfected with human galanin Gal1 receptor, 400 units.
List Price : 909.00 USD

Vinblastine Sulphate, [G-3H]

Vinblastine sulphate, tritiated. Vinblastine binds to tubulin and inhibits microtubule formation.
Price Range : 1530.00 USD - 5700.00 USD
Receptor-expressing cell lines

ValiScreen Free Fatty Acid FFA1 (GPR40) (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.

Scopolamine Methyl Chloride, [N-methyl-3H]

Scopolamine methyl chloride, tritiated on the N-methyl group. Scopolamine acts as an antagonist at muscarinic acetylcholine receptors.
Price Range : 1512.00 USD - 3468.00 USD

Astemizole, [O-Methyl-3H]

Astemizole (Hismanal) tritiated at the O-methyl group. Atemizole is an antagonist of the histamine H1-receptor and has been shown to block hERG potassium channels.
Price Range : 701.00 USD - 7000.00 USD
PerkinElmer

Anti-mouse PVT 500 MG

Anti-mouse-coated SPA beads, for capturing mouse IgG antibodies in proximity-based radiometric scintillation assays.
List Price : 831.00 USD

Goat anti-rabbit IgG, [125I]

Anti-rabbit immunoglobulin G (IgG), labeled with 125I. I-125 labeled anti-rabbit IgG can be used as a tracer to capture rabbit IgG antibodies in radioimmunoassays (RIAs).
Price Range : 839.00 USD - 983.00 USD
Receptor-expressing cell lines

ValiScreen Histamine H1 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.

CP 55940, [Side Chain-2,3,4-3H(N)]

CP 55,940, tritiated on the side chain-2,3-4 position. CP 55,940 is a synthetic cannabinoid that acts as a full agonist at both cannabinoid CB1 and CB2 receptors, and can also upregulate serotonin 5-HT2A receptors.
Price Range : 669.00 USD - 4915.00 USD

Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid (AMPA), DL-α-[5-Methyl-3H]

DL-α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid (AMPA), tritiated at the 5-methyl position. AMPA acts as an agonist at the AMPA receptor.
Price Range : 567.00 USD - 4183.00 USD
PerkinElmer

Membrane Target Systems: Prostanoid DP (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 936.00 USD
PerkinElmer

PDE YSI 500MG

SPA (scintillation proximity assay) beads designed for the capture of [3H]AMP or [3H]GMP on specially prepared yttrium silicate beads.
List Price : 831.00 USD
PerkinElmer

Membrane Target Systems: Cholecystokinin CCK1 (human) membrane preparation, in 1321N1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 867.00 USD

ANGIOTENSIN II (human), [125I]-Tyr4 -50 μCi

Angiotensin II (human), labeled with 125I on the tyrosine (Tyr4) residue. Angiotensin II binds and activates angiotensin II receptor type 1 (AT1) and type 2 (AT2) receptors, a class of GPCRs important in vasoconstriction. Angiotensin II is a potential drug target for blood pressure regulation.
List Price : 2031.00 USD
PerkinElmer

Membrane Target Systems: Opioid Mu (OP3) (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 936.00 USD
PerkinElmer

DELFIA® L*R binding buffer concentrate (10x), 250 mL

Buffer for DELFIA® time-resolved fluorescence (TRF) ligand binding assays.
List Price : 548.00 USD

Urotensin II (human), [125I]Tyr9

Urotensin II, labeled with 125I. Urotensin II is a vasoconstrictor that binds the urotensin-II receptor.
Price Range : 1513.00 USD - 2364.00 USD

Enkephalin, [Tyrosyl-2,6-3H(N)]- (2-D-Penicillamine, 5-D-Penicillamine) (DPDPE)

2-D-Penicillamine, 5-D-Penicillamine (DPDPE), tritiated on the tyrosyl group. Cyclic peptide, sequence: Tyr-D-Pen-Gly-Phe-D-Pen-OH. DPDPE is a synthetic enkephalin opioid peptide that acts as an agonist at delta opiate receptors (δ-opioid receptor, DOR).
Price Range : 971.00 USD - 4717.00 USD
PerkinElmer

ProfilerPro Kinase Peptide Substrate 14, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 14 for kinase assays (inhibiton, target discovery, lead optimization)
List Price : 721.00 USD
PerkinElmer

Membrane Target Systems: Adenosine A1 (rat) membrane preparation, in CHO-K1 cells. 400 Units.

Cell membranes prepared from CHO-K1 cells stably-transfected with rat adenosine A1 receptor, 400 units.
List Price : 936.00 USD

3-INDOLYLACETIC ACID, [5-3H(N)]-

3-Indolyacetic acid tritiated at the 5 position. Indole-3-acetic acid (IAA, 3-IAA) is the most common, naturally occurring, plant hormone of the auxin class.
List Price : 1463.00 USD
Receptor-expressing cell lines

ValiScreen Relaxin RXFP3 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
PerkinElmer

Membrane Target Systems: Adrenergic alpha 2B (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 936.00 USD

Serine, D-[3H(G)]-, 250µCi (9.25MBq)

Tritiated D-Serine. D-Serine acts as an agonist at N-methyl-D-aspartate receptors (NMDA receptors).
List Price : 1981.00 USD

Quinuclidinyl Benzilate, L-[Benzilic-4,4`-3H]-, 250µCi (9.25MBq)

L-quinuclidinyl benzilate (QNB), tritiated at the benzilic-4,4' position. L-quinuclidinyl benzilate acts as an antagonist at muscarinic acetylcholine receptors.
List Price : 1396.00 USD

GLP-1 (7-36), [125I]

Glucagon-like peptide-1 (GLP-1), labeled with 125I. GLP-1 is a peptide hormone involved in secretion of insulin, and binds and activates GLP-1 receptors, a member of the glucagon receptor family of GPCRs.
Price Range : 1219.00 USD - 2224.00 USD

"Receptor Ligand Binding" 1-50 of 550 Products and Services

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