PerkinElmer

Receptor Ligand Binding

OF

A receptor ligand binding assay allows for the study and simple imaging of cell surface receptors for research and diagnostic applications. Receptor ligand binding is used in drug development applications to identify blocking antibodies or inhibitors that can modulate downstream signaling events, and is often used to screen for drugs that target hormone and neurotransmitter activity. We offer a range of tools for receptor ligand binding assays including radioligands, receptor-transfected cell membranes, and cell lines. Products available support both agonist and antagonist assays.

Our offerings include assays for:

  • Tyrosine kinase receptors
  • G-protein coupled receptors (GPCR)
  • Drug discovery and development
  • Ion channels
  • Protein analysis, detection, and interaction

Our collection of receptor ligand binding related assays includes fluorescence, LANCE® and DELFIA® time-resolved fluorescence, Alpha chemiluminescent assays, lites luminescence assays, and radiometric detection methods. Simplify the development of your assays and the calculation of your results using our radioligands, receptor-transfected cell membranes, and cell lines for receptor ligand binding applications.

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Product Type
  • Consumables (2)
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  • Reagents (538)
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Application
  • cAMP (26)
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Therapeutic Area
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Product Brand Name
  • AequoScreen (4)
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  • White (4)
Coating Treatment
  • Anti-mouse antibody (2)
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  • WGA PEI type A (1)
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Material
  • Barex/GF/B (1)
  • Barex/GF/C (1)
  • Polystyrene/GF/B (1)
  • Polystyrene/GF/C (1)
Detection Method
  • Alpha (3)
  • DELFIA TRF (4)
  • Filtration (4)
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  • Radiometric (248)
  • Time-Resolved Fluorescence (TRF) (4)
Receptor Type
  • 5-Hydroxytryptamine (12)
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  • Insulin-like Growth Factor (1)
  • Interleukin (1)
  • Leukotriene (3)
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  • Prostanoid (9)
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  • Thyrotropin-releasing Hormone (2)
  • Transforming Growth Factor (1)
  • TRPC5 (1)
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  • Vasoactive Intestinal Peptide (3)
  • Vasopressin (12)
  • Vesicular Amine Transporters (VATs) (1)
Assay Validated
  • Binding (213)
  • Calcium Fluorescence (21)
  • Calcium Luminescence (9)
  • cAMP (56)
  • Downstream Phosphorylation (1)
  • GTPγS (54)
  • Inositol Phosphate (15)
Sample Type
  • Enzyme (38)
Radioisotope
  • C-14 (6)
  • H-3 (109)
  • I-125 (77)
  • S-35 (1)
Radionuclide
  • 125I (77)
  • 14C (5)
  • 35S (1)
  • 3H (1)
  • 3H (108)
Fluorophore
  • Eu-N1-ITC (2)
Label Position
  • Generally Labeled (6)
  • Nominally Labeled (96)
  • Specifically Labeled (90)
  • Uniformly Labeled (1)
Assay points(200-50,000)
  • 500 (2)
  • 5000 (2)
Assay Target Class
  • GPCR (187)
  • Ion channel (2)
  • Transporter (6)
  • Tyrosine Kinase Receptor (1)
Automation Compatible
  • No (20)
  • Yes (50)
Concentration
  • 1 mCi/mL (3)
  • 1.0 - 10 mCi/mL (57)
  • 1.0 - 10 µCi/mL (3)
  • 1.12 mCi/mL (1)
  • 1.14 mCi/mL (1)
  • 152 µCi/mL (1)
  • 170.1 µCi/mL (1)
  • 171 µCi/mL (1)
  • 172.5 µCi/mL (1)
  • 173.9 µCi/mL (1)
  • 182 µCi/mL (2)
  • 2.93 MBq/mL (1)
  • 236 µCi (1)
  • 3.06 MBq/mL (1)
  • 3.22 MBq/mL (1)
  • 33.7 µCi (1)
  • 345 µCi/mL (3)
  • 353 µCi/mL (3)
  • 41.4 µCi/mL (2)
  • 42.5 µCi/mL (1)
  • 45.7 µCi/mL (1)
  • 50 µCi/mL (1)
  • 6.05 MBq/mL (1)
  • 79.2 µCi/mL (2)
  • 83.8 µCi/mL (1)
  • 85.1 µCi/mL (1)
  • 87.2 µCi/mL (1)
  • 87.4 µCi/mL (1)
  • 87.6 µCi/mL (1)
  • 87.9 µCi/mL (1)
  • 88.5 µCi/mL (1)
  • 93.2 µCi/mL (1)
  • <1.0 mCi/mL (7)
  • <1.0 µCi/mL (3)
  • <100 µCi/mL (1)
Experimental Type
  • In vitro (4)
Format
  • Microplates (19)
  • Tubes (11)
Host Cell
  • 1321N1 (11)
  • A431 (1)
  • A9 (1)
  • CHO-DHFR(-) (1)
  • CHO-K1 (138)
  • HEK293 (41)
  • HT29 (1)
  • K562 (1)
  • L Cells (1)
  • MDA-MB-435S (1)
  • MDCK (2)
  • U373 (1)
  • UC11 (1)
Length
  • 51-100 (6)
Number of Wells
  • 96 (4)
Pipetting Arms
Volume
  • 0-50 (44)
  • 51-100 (1)
  • 201-250 (56)

"Receptor Ligand Binding" 1-50 of 547 Products & Services

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OMNIFILTER-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the OmniFilter Harvester.

UNIFILTER-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the Unifilter Harvester.

UNIFILTER-96 CELL HARVESTER SS

Speed and simplicity are the primary strengths of the Unifilter Harvester.

MICROBETA FILTERMAT-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the FilterMate Harvester. From beginning to end, the FilterMate system is easy to use.

MICROBETA FILTERMAT-24 CELL HARVESTER

Speed and simplicity are the primary strengths of the FilterMate Harvester. From beginning to end, the FilterMate system is easy to use. Need additional information? Click on the tabs in the product details section below.

UNIFILTER-24 CELL HARVESTER

Speed and simplicity are the primary strengths of the Unifilter Harvester.
LabChip EZ Reader

EZ READER, SHIP LEVEL

The EZ Reader can help to save time and money in your laboratory by identifying the most promising lead candidates faster.

The EZ Reader instrument is available outside the EU. Please contact your local representative for further information.

Alpha Bungarotoxin

Neurokinin B, [125I]His, MePhe7

Neurokinin B (NKB), labeled with 125I on the histidine residue. Neurokinin B is involved in ovarian cycle regulation, and binds neurokinin 3 receptor (NK3R; tachykinin receptor 3), a GPCR involved in vascular remodeling, angiogenesis, and cancer.
Price Range : 1077.00 USD - 2512.00 USD
Receptor-expressing cell lines

ValiScreen Neuropeptide FF NPFF2s (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
Adenosine 5 Triphosphate 250 µCi

Bradykinin, [2,3-Prolyl-3,4-3H(N)]

Bradykinin, tritiated at the 2,3-prolyl-3,4 position. Bradykinin is the endogenous ligand that activates bradykinin B1 and B2 receptors.
Price Range : 1935.00 USD - 4417.00 USD
Receptor-expressing cell lines

ValiScreen Melanocortin MC5 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
PerkinElmer

ProfilerPro Kinase Peptide Substrate 7, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 7 for kinase assays (inhibiton, target discovery, lead optimization)
List Price : 757.00 USD
PerkinElmer

Membrane Target Systems: Orexin OX1 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 982.00 USD
Diclofenac sodium- Phenylacetic acid C14

Caffeine, [1-Methyl-14C]-, 50µCi (1.85MBq)

Caffeine, radiolabeled with C-14 at the 1-methyl position. Caffeine acts as a non-selective antagonist at adenosine receptors.
List Price : 897.00 USD
PerkinElmer

PDE Substrate iFL-cGMP, for LabChip EZ Reader

Fluorescently-labelled cGMP for Phosphodiesterase Assays (Enyzme inhibiton, target discovery, lead optimization)
List Price : 757.00 USD
Alpha Bungarotoxin

RTI-55, [125I]

RTI-55, labeled with 125I. RTI-55 is a nonselective dopamine reuptake inhibitor that is used to assess neuron degradation in Parkinson's disease and other neurodegenerative diseases.
Price Range : 994.00 USD - 1981.00 USD
Receptor-expressing cell lines

ValiScreen Apelin APJ (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
PerkinElmer

Glutathione YSI 50MG

Glutathione-coated SPA beads, for capturing GST-tagged proteins in proximity-based radiometric scintillation assays.
List Price : 872.00 USD
Adenosine 5 Triphosphate 250 µCi

Dofetilide, [N-methyl-3H], 100 µCi

Dofetilide, tritiated at the N-methyl position. Dofetilide is a selective potassium channel (hERG) blocker.
List Price : 1733.00 USD
PerkinElmer

Membrane Target Systems: Melanocortin MC4 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 982.00 USD
Alpha Bungarotoxin

Insulin (porcine), Receptor Grade, [125I]TyrA14]

Porcine insulin, labeled with 125I on tyrosineA14. This product is receptor-grade, and was developed for receptor-binding assays. Insulin binds and activates insulin receptor (IR), a tyrosine kinase receptor involved in glucose uptake.
Price Range : 1269.00 USD - 2475.00 USD
Adenosine 5 Triphosphate 250 µCi

Norepinephrine, Levo-[ring-2,5,6-3H]

Levo-Norepinephrine, tritiated on the ring group. Norepinephrine binds and activates adrenergic receptors, and is cleared by the norepinehprine transporter (NET).
Price Range : 1458.00 USD - 9300.00 USD
PerkinElmer

Membrane Target Systems: Melatonin MT1 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Cell membranes expressing recombinant human melatonin MT1 receptor, for ligand binding assays. Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 891.00 USD
PerkinElmer

ProfilerPro Kinase Peptide Substrate 6, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 6 for kinase assays (inhibiton, target discovery, lead optimization)
List Price : 757.00 USD
PerkinElmer

ProfilerPro Kinase Peptide Substrate 12, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 12 for kinase assays (inhibiton, target discovery, lead optimization)
List Price : 757.00 USD
Adenosine 5 Triphosphate 250 µCi

Nitrendipine, [5-Methyl-3H]-, 25µCi (925kBq)

Nitrendipine, tritiated on the 5-methyl group. Nitrendipine is a dihydropyridine calcium channel blocker.
List Price : 1162.00 USD
Alpha Bungarotoxin

TGF-β1 (human, recombinant), [125I]

Transforming growth factor beta 1 (TGF-β1), labeled with 125I. TGF-β1 is a cytokine that is involved in cell growth, cell differentiation, and apoptosis.
Price Range : 930.00 USD - 2329.00 USD
Adenosine 5 Triphosphate 250 µCi

Verapamil Hydrochloride, [N-Methyl-3H]

Verapamil hydrochloride, tritiated on the N-methyl group. Verapamil acts as a calcium channel blocker (CCB).
Price Range : 748.00 USD - 3600.00 USD
PerkinElmer

ProfilerPro Kinase Selectivity Assay Plate Kit 1, for LabChip EZ Reader

Kit consist of matched pairs of 384-well kinase-assay and substrate plates. Each assay plate contains 24 different predispensed frozen kinases. Substrate plates contain the appropriate fluorescent labeled peptides and ATP.
List Price : 1637.00 USD
PerkinElmer

Membrane Target Systems: Vasopressin V1b (human) membrane preparation, in CHO-K1 cells. 400 Units.

Cell membranes prepared from CHO-K1 cells stably-transfected with human Vasopressin V1b receptor, 400 units.
List Price : 982.00 USD
Adenosine 5 Triphosphate 250 µCi

Norepinephrine, Levo-[7-3H]

Levo-Norepinephrine, tritiated at the 7 position. Norepinephrine binds and activates adrenergic receptors, and is cleared by the norepinehprine transporter (NET). This product has a scheduled lot release for the third Monday in July.
Price Range : 1315.00 USD - 10900.00 USD

DELFIA Eu-Labeling kit (Eu-N1-ITC chelate), 0.2mg

DELFIA® Europium labeling kit for labeling your own biomolecules for use in DELFIA time-resolved fluorescence assays. The ITC chelate reacts with free amine groups in the target biomolecule.
List Price : 564.00 USD
PerkinElmer

Membrane Target Systems: Neuropeptide NPFF1 (human) membrane preparation in CHO-K1 cells

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 982.00 USD
Alpha Bungarotoxin

PDGF [125I] (human)

NEX433 [125I]-PDGF BB homodimer has been shown to work in RIA and receptor studies, using CHO cell line transfected with human PDGF B receptor, and human artery smooth muscle cells.
Price Range : 1028.00 USD - 2314.00 USD
Adenosine 5 Triphosphate 250 µCi

Chloramphenicol, [Ring-3,5-3H]

Chloramphenicol, tritiated at the ring-3,5 position. Chloramphenicol is a broad spectrum antibiotic that binds to a receptor site on the 50S subunit of the bacterial ribosome, inhibiting peptidyl transferase.
Price Range : 2073.00 USD - 5200.00 USD

UniFilter-96 GF/B PEI Coated Plates - Case of 50

PEI-coated GF/B glassfibre filter-bottom 96-well microplate, for receptor binding and cell harvesting assays using a vacuum manifold.
List Price : 1149.00 USD
PerkinElmer

WGA PVT SPA 100 MG

WGA-coated SPA beads, for capturing cell membranes in proximity-based radiometric scintillation assays.
List Price : 191.00 USD
Receptor-expressing cell lines

ValiScreen Melanocortin MC3 (mouse) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
Adenosine 5 Triphosphate 250 µCi

PK 11195, [N-Methyl-3H]

PK-11195, tritiated on the N-methyl group. PK-11195 binds selectively to the peripheral benzodiazepine receptor (PBR).
Price Range : 2200.00 USD - 4926.00 USD
Adenosine 5 Triphosphate 250 µCi

Quinuclidinyl Benzilate, L-[Benzilic-4,4'-3H]-, 250µCi (9.25MBq)

L-quinuclidinyl benzilate (QNB), tritiated at the benzilic-4,4' position. L-quinuclidinyl benzilate acts as an antagonist at muscarinic acetylcholine receptors.
List Price : 1536.00 USD
PerkinElmer

Membrane Target Systems: Vasoactive Intestinal Polypeptide VIP membrane preparation

Cell membranes prepared from HT29 cells containing human endogenous Vasoactive Intestinal Polypeptide (VIP) receptor.
List Price : 1029.00 USD
PerkinElmer

Membrane Target Systems: Dopamine D3 (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
List Price : 982.00 USD
PerkinElmer

CHO cell membranes, 10 mg

Wild Type Subtype CHO-K1 (chinese hamster) Control Membrane 10mg frozen suspension cell membrane. Shipped on dry ice.
List Price : 585.00 USD
Adenosine 5 Triphosphate 250 µCi

Pirenzepine, [N-Methyl-3H]

Pirenzepine, tritiated on the N-methyl group. Pirenzepine acts as a selective antagonist of the muscarinic M1 acetylcholine receptor.
Price Range : 2134.00 USD - 5400.00 USD
Alpha Bungarotoxin

Neurotensin, [125I]Tyr3

Neurotensin, labeled with 125I on the tyrosine 3 residue. Neurotensin functions as an agonist at neurotensin receptors. It is known to induce analgesia, hypothermia and increased locomotor activity. Neurotensin is also involved in the regulation of dopamine.
Price Range : 1106.00 USD - 2312.00 USD

FcγR3B (CD16b) AlphaLISA Binding Kit

The AlphaLISA FCGR3B (CD16b) binding kit is designed for the detection of binding between FcγR3B (CD16b) and human IgG Fc fragment using a homogeneous AlphaLISA assay (no wash steps). This assay can facilitate the design and development of antibody therapeutics using a competition assay format.
Price Range : 2213.00 USD - 11100.00 USD
Receptor-expressing cell lines

ValiScreen TRH (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
Receptor-expressing cell lines

Bradykinin B2 AequoScreen Cell Line

Our stable recombinant AequoScreen cell lines express a variety of GPCRs which all couple to a calcium response. Upon GPCR stimulation and subsequent calcium binding to the aequorin oxidation of coelenterazine leads to emission of light.
List Price : 18500.00 USD
Receptor-expressing cell lines

ValiScreen Muscarinic M5 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
Alpha Bungarotoxin

Recombinant Protein A, [125I]

Recombinant Protein A, labeled with 125I. I-125 labeled Protein A can be used as a general tracer to capture antibodies in radioimmunoassays (RIAs).
Price Range : 854.00 USD - 1382.00 USD

"Receptor Ligand Binding" 1-50 of 547 Products & Services

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