Radiometric detection is considered the gold standard for many applications, from drug discovery and development to plant sciences. The technique achieves sub-femtogram sensitivity levels, and quantitates the binding and activity of radiolabeled compounds with high specificity and sensitivity. As the leading supplier of research radiochemicals, we offer a broad portfolio of products for any radiochemistry need.
Our radiochemical analysis products include:
Radionuclides such as 124I, 14C, 89Zr, 90Y, 125I, 131I, 22Na, 32P, 35S, 3H, 45Ca, 51Cr, 54Mn, 55Fe, 59Fe, 85Sr
EasyTag™ protein labeling mixes
EasyTide radiolabeled nucleotides
NEN radiolabeled compounds
SPA Enzymatic assays and imaging beads
Our radiolabeled compounds are useful in a wide range of applications:
Research in cancer, CNS and neurologic disease, cardiovascular and metabolic disease, inflammation, and other disorders
Kinetic and mechanistic studies
Radiometric cAMP assays
Detection of binding to over 80 different receptor types
Our radiometric reagents are not reliant on the use of antibodies for detection and read-out – just one of the reasons they are so widely used.
2-deoxy-D-glucose, labeled at the 1,2 position with tritium. This glucose analog is readily transported into most cells and cannot be further metabolized, and is commonly used in glucose uptake assays.
Estradiol, labeled with tritium. 3H-estradiol is commonly used in estrogen receptor binding assays and estrodiol radioimmunoassays (RIAs). This product will have scheduled availability dates on the second Monday in June and December.
GR125743, tritiated on the N-methyl group. GR125743 acts as an antagonist at serotonin 5-HT1B and 5-HT1D receptors. This product will have scheduled availability dates on the third Monday in February and August.
Vasoactive intestinal polypeptide (VIP), labeled with 125I. VIP binds vasoactive intestinal peptide receptors VPAC1 and VPAC2, a group of GPCRs that are potential drug targets for nervous and endocrine disorders and several types of cancer.