Radiometric detection is considered the gold standard for many applications, from drug discovery and development to plant sciences. The technique achieves sub-femtogram sensitivity levels, and quantitates the binding and activity of radiolabeled compounds with high specificity and sensitivity. As the leading supplier of research radiochemicals, we offer a broad portfolio of products for any radiochemistry need.
Our radiochemical analysis products include:
Radionuclides such as 14C, 89Zr, 125I, 32P, 35S, 3H, 45Ca, 51Cr, 55Fe
EasyTag™ protein labeling mixes
EasyTide radiolabeled nucleotides
NEN radiolabeled compounds
SPA Enzymatic assays and imaging beads
Our radiolabeled compounds are useful in a wide range of applications:
Research in cancer, CNS and neurologic disease, cardiovascular and metabolic disease, inflammation, and other disorders
Kinetic and mechanistic studies
Radiometric cAMP assays
Detection of binding to over 80 different receptor types
Our radiometric reagents are not reliant on the use of antibodies for detection and read-out – just one of the reasons they are so widely used.
Diclofenac sodium, labeled with C-14 on the phenylacetic acid ring. Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that acts as an antagonist at peroxisome prolifeator-activated receptor gamma (PPAR-γ or PPARG).
5-Hydroxytryptamine Binoxalate (Serotonin Binoxalate), labeled with C-14 at the 1-position. 5-Hydroxytryptamine is a neurotransmitter and is the endogenous ligand for serotonin receptors. NEC855 replaces product NEC225, which was labeled at the 2-position.
2-Deoxy-D-glucose, nominally labeled with tritium at C1/C2. This product is supplied steri-packaged in an aqueous solution. Deoxy-D-glucose (DOG) is a glucose analog that is readily transported into most cells, is phosphorylated and trapped by the cells (unidirectional transport), and cannot be further metabolized. It is the most-common chemical used in glucose uptake assays.