Radiometric detection is considered the gold standard for many applications, from drug discovery and development to plant sciences. The technique achieves sub-femtogram sensitivity levels, and quantitates the binding and activity of radiolabeled compounds with high specificity and sensitivity. As the leading supplier of research radiochemicals, we offer a broad portfolio of products for any radiochemistry need.
Our radiochemical analysis products include:
Radionuclides such as 14C, 89Zr, 125I, 32P, 35S, 3H, 45Ca, 51Cr, 55Fe
EasyTag™ protein labeling mixes
EasyTide radiolabeled nucleotides
NEN radiolabeled compounds
SPA Enzymatic assays and imaging beads
Our radiolabeled compounds are useful in a wide range of applications:
Research in cancer, CNS and neurologic disease, cardiovascular and metabolic disease, inflammation, and other disorders
Kinetic and mechanistic studies
Radiometric cAMP assays
Detection of binding to over 80 different receptor types
Our radiometric reagents are not reliant on the use of antibodies for detection and read-out – just one of the reasons they are so widely used.
Human growth hormone (HGH), labeled with 125I. Human growth hormone stimulates growth, cell reproduction and regeneration in animals. HGH functions to regulate body composition, fluid homeostasis, glucose and lipid metabolism, skeletal muscle and bone growth.
Chromium-51 (51Cr) radionuclide, commonly used as a label for target cells in chromium release assays, cell-mediated cytotoxicity studies, antibody-dependent cytotoxicity (ADCC) studies, and CAR-T cell development. Target cells uptake 51Cr radionuclide, and release the nuclide into the culture media upon cytolysis or cell death.
Triiodothyronine (T3) labeled with 125I. Triiodothyronine is a thyroid hormone that affects growth and development, body temperature, and heart rate. T3 detection by radioimmunoassay is a common test of thyroid gland function. This product is offered at three specific activities. Specific activity indicates how much radioactivity there is per molecule of ligand. Several of our 125I-labeled ligands are offered at maximum specific activity (2200 Ci/mmol if one 125I labeling site is available, 4400 Ci/mmol if two labeling sites are available).
Human pancreatic polypeptide (PP), labeled with 125I. Pancreatic polypeptide acts as an agonist at Pancreatic polypeptide receptors (Neuropeptide Y receptors), a class of GPCRs involved in appetite, circadian rhythm, and anxiety.