Product Manufacturing and Quality Control Solutions Related Content
Pesticide and Mycotoxin Testing
Our QSight® 420 Pesticide Analyzer utilizes a single instrument and single prep method for rapid, reliable results — suitable for labs wanting to comply with stringent regulations. This method allows identification and quantification of all pesticides and mycotoxins at levels well below action limits (10-50ppb). The ability to screen and quantitate the hydrophobic and chlorinated compounds normally analyzed on a GC-MS/MS, as well as all the mycotoxins, makes it the ideal analytical technique for the cannabis industry.
Liquid chromatography-tandem mass spectrometry (LC/MS/MS) has become the method of choice for pesticide. The state of Oregon has issued regulatory limits for 59 pesticide residues in both cannabis flower and concentrates, while other states have come up with their own lists of pesticide residues relating to medical marijuana and cannabis testing.
The use of cannabis concentrates and CBD products (edibles, topicals, vape products, etc.) has increased in popularity as new regulation has been passed legalizing medicinal and recreational use in a number of states and provinces. Testing to ensure that pesticide and mycotoxin levels in cannabis products are below regulatory levels is critical, however, the cannabis concentrate matrix presents many analytical challenges including higher sample matrix effects and an increased concentration of cannabinoids in the sample. In this application note, an LC/MS/MS method for the analysis of 66 pesticides (including hydrophobic and chlorinated pesticides typically analyzed by GC/MS/MS) and five mycotoxins in a cannabis concentrate matrix is presented. Utilizing a QSight® 420 LC/MS/MS instrument with dual APCI and ESI sources, the analysis yielded excellent recoveries and detection limits below those specified by the state of California cannabis regulations.
Following the 2018 legalization of recreational cannabis usage in Canada, the quality and safety of cannabis products has garnered significant attention. Health Canada has developed a regulatory program mandating pesticide testing on all cannabis products. Under the program, licensed producers (LPs) of cannabis products in Canada are required to send representative samples of products to independent laboratories for pesticide screening and quantification. In this application note, a robust and reliable method for the analysis of 96 pesticides in cannabis flower by LC/MS/MS utilizing both ESI and APCI modes is presented. The method not only offers ultra-low detection limits at or below the Health Canada regulatory levels, but also offers significant efficiency gains over other available methodologies. Utilizing LC/MS/MS with both ESI and APCI modes obviates the need to perform both GC/MS/MS and LC/MS/MS analyses to analyze all 96 regulated pesticides, saving significant time and money for operators.
Testing for the levels of pesticide and mycotoxins in cannabis is important to ensure consumer safety and quality control. In this work, the PerkinElmer application development team analyzed all 66 pesticides (including very hydrophobic and chlorinated pesticides typically analyzed by GC-MS/MS) and five mycotoxins spiked in cannabis flower extracts well below the action limits specified by the state of California. A LC-MS/MS instrument was used with ESI and APCI sources and a simple solvent extraction method with excellent recoveries for all analytes in acceptable range of 70-120%.
Agricultural growing of hemp products for the purposes of cannabidiol (CBD) extraction was legalized in the United States with the passing of the Agricultural Improvement Act of 2018. Since the act passed, heightened concern over the use of pesticides in hemp production has been appreciated. However, no federal guidance is currently available in the United States to standardize analytical methods for the detection and quantification of pesticide residues in hemp products. In this application note, a robust and efficient single-run LC/MS/MS method for the determination of 66 pesticides, including hydrophobic and chlorinated pesticides typically analyzed by GC/MS/MS, is presented. Utilizing a PerkinElmer QSight® 420 UHPLC with MS/MS detector and dual ESI and APCI sources, excellent recoveries in the range of 70-120% were achieved. The application note also outlines participation in an Emerald Scientific blind proficiency test, with acceptable results for all 66 pesticides.
Residual Solvents & Terpene Testing
The determination and understanding of terpenes and residual solvents concentrations are critical phases of cannabis testing.
PerkinElmer has developed a methods for residual solvent and terpene analysis on the GC/MS-HS that are the fastest in the indsutry, allowing Labs the greatest effeciency.
Solvent such as supercritical CO2, butane, propane, other hydrocarbons, water, or alcohol are used to extract out the cannabinoids and terpenes from the plant material. In some cases, the solvent and impurities from the solvent remain in the extracted material. This study will shows the analysis of residual solvents using pressure-balanced headspace (HS) sample introduction coupled with Gas Chromatography/Mass Spectrometry (GC/MS). Unambiguous separation of all compounds is obtained while maximizing sample throughput.
Naturally occurring cannabinoids are the main biologically active components of the cannabis and hemp plant. Thanks to our collaboration with contract laboratories, we have developed industry-leading methods to allow you to run your potency testing with confidence and getting a fast return of investment. Our LC-based method chromatographically separates and quantifies 16 primary cannabinoids. In addition, our Spectrum Two FT-NIR™ determines THC/CDB potency ratio in ground cannabis flower. It is a quick and nondestructive method that requires little to no sample preparation, no hazardous chemicals, and allows the sample to be reused in other analyses.
Pathogen & Microbial Testing
Our products and solutions are intended to be used for analytical testing of cannabis in laboratories where such use is permitted under state and/or country law. We do not support or promote the use of its products or solutions in connection with illegal use. Further, we are not condoning the use of recreational or medical marijuana.
Cannabis & Hemp Related Technologies