Operetta® CLS™ is a high throughput microplate imager for high-content analysis (HCA). It can acquire, analyze and manage fluorescence, brightfield and digital phase contrast images. The combination of high power LED excitation with fast, precise mechanics and one large format sCMOS camera enables fast imaging. Controlled by Harmony™ software it offers a seamless workflow, for reliable discrimination of phenotypes even in complex cellular models.
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Features at a Glance
Intelligent image acquisition
Target more accurately your object of interest for significantly reduced acquisition and analysis times, particularly valuable for 3D microtissue and rare event studies.
Easily create algorithms without being an image analysis expert using our PhenoLOGIC proprietary machine-learning technology.
Easily quantify cellular phenotypes in complex 3D models
Explore your cell models by visualizing them in a 3D- and an XYZ-viewer and quantify volumetric and other 3D related phenotypic readouts.
Powerfully simple analysis capabilities
Harmony® high-content imaging and analysis software - is the easy-to-learn, easy-to-use software that can make you more productive - faster.
High efficiency excitation design
Direct coupling limits the light loss that is typical of light guides or fibers.
Fast Frame Rate Imaging
Capture rapid cellular changes with an imaging frame rate up to 105 fps.
Automated water-immersion objectives
From the company with more than 20 years of experience - giving faster exposure times, increased resolution and reduced photodamage.
Confocal spinning-disk technology
Provides a gentle imaging process (especially for live-cell experiments) with efficient background rejection.
A Solution Configured to Suit Every Need
Whatever your application, there’s an Operetta CLS system configured to meet your requirements. And it’s modular, so it can change with your research demands.
Operetta® CLS™ Quattro
With four LEDs and widefield fluorescence, the basic configuration of the Operetta CLS™ system is ideal for common applications that need sensitivity and resolution, with the capacity to grow if the need arises.
Operetta® CLS™ FLEX
With eight LEDs, and confocal and widefield fluorescence, the FLEX configuration offers flexibility in excitation and imaging modes for many challenging applications – and it can be upgraded to even higher performance.
Operetta® CLS™ LIVE
With all the features of the FLEX configuration, plus gas and temperature control and water-immersion objectives, this system is ideal for gentle yet highly sensitive live-cell imaging.