Operetta CLS High Content Analysis System

Operetta^® CLS^™ is a high throughput microplate imager for high-content analysis (HCA). It can acquire, analyze and manage fluorescence, brightfield and digital phase contrast images. The combination of high power LED excitation with fast, precise mechanics and one large format sCMOS camera enables fast imaging. Controlled by Harmony^™ software it offers a seamless workflow, for reliable discrimination of phenotypes even in complex cellular models.

To view our library of resources, images, and videos, visit the Resources and Image/Video Gallery sections below.

Features at a Glance

Intelligent image acquisition

Target more accurately your object of interest for significantly reduced acquisition and analysis times, particularly valuable for 3D microtissue and rare event studies.

Machine learning

Easily create algorithms without being an image analysis expert using our PhenoLOGIC proprietary machine-learning technology.

Easily quantify cellular phenotypes in complex 3D models

Explore your cell models by visualizing them in a 3D- and an XYZ-viewer and quantify volumetric and other 3D related phenotypic readouts.

Powerfully simple analysis capabilities

Harmony^® high-content imaging and analysis software - is the easy-to-learn, easy-to-use software that can make you more productive - faster.

High efficiency excitation design

Direct coupling limits the light loss that is typical of light guides or fibers.

Fast Frame Rate Imaging

Capture rapid cellular changes with an imaging frame rate up to 105 fps.

Automated water-immersion objectives

From the company with more than 20 years of experience - giving faster exposure times, increased resolution and reduced photodamage.

Confocal spinning-disk technology

Provides a gentle imaging process (especially for live-cell experiments) with efficient background rejection.

Customer Testimonials

Dr. Davide Danovi
Centre for Stem Cells & Regenerative Medicine
King's College London

Univ. Prof. Dr. Doris Wilflingseder
Institute of Hygiene and Medical Microbiology
Medical University of Innsbruck

A Solution Configured to Suit Every Need

Whatever your application, there’s an Operetta CLS system configured to meet your requirements. And it’s modular, so it can change with your research demands.

Configurations

Operetta^® CLS^™ Quattro

With four LEDs and widefield fluorescence, the basic configuration of the Operetta CLS™ system is ideal for common applications that need sensitivity and resolution, with the capacity to grow if the need arises.

Operetta^® CLS^™ FLEX

With eight LEDs, and confocal and widefield fluorescence, the FLEX configuration offers flexibility in excitation and imaging modes for many challenging applications – and it can be upgraded to even higher performance.

Operetta^® CLS^™ LIVE

With all the features of the FLEX configuration, plus gas and temperature control and water-immersion objectives, this system is ideal for gentle yet highly sensitive live-cell imaging.

Image/Video Gallery

Resources

analysis-of-mitochondrial-dynamics-in-human-ipsc-derived-neurons-512x288.jpg

Mitochondrial dynamics are essential for energy conversion and neuron survival. Understanding changes in mitochondrial dynamics is therefore crucial in developi ...

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The product of more than a decade of experience in high-content screening, the Operetta CLS delivers the speed and sensitivity for everyday assays, and even com ...

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Phenotypic Drug Discovery Re-Imagined Cell Painting is a phenotypic screening method and a powerful application of high-content screening technology which combi ...

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Extracellular signal-regulated kinase (ERK) is a key component in the regulation of embryogenesis, cell differentiation, cell proliferation, and cell death. The ...

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The promise of high-content screening is the acceleration of discovery by extracting as much relevant information as possible from cells. Nevertheless, a large ...

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Publications in which PerkinElmer high-content analysis and screening systems are used number more than 1000 between 2010 and 2019. Here we feature some of the ...

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Whether you’re familiar with high-content screening and are looking to exploit the increased physiological relevance of complex 3D cell models, or you want to t ...

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Multicellular 3D “oids” (tumoroids, spheroids, organoids) have the potential to better predict the effects of drug candidates during preclinical screening. Howe ...

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The key parameters in high-content imaging - speed, sensitivity (or intensity) and resolution - cannot be optimized independently as altering one of them influe ...

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This webinar will describe the marriage of 3D organoids and high-content screening (HCS) to discover targeted drug therapies effective against the malignant phe ...

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