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New assays are available in Alpha SureFire® Ultra™ and HTRF® technologies within several different therapeutic areas.
In addition to the targets above new oncology targets, CDK2 and CDK4, are available in the Alpha CETSA®, as well as kits for cereblon binding and total detection for protein degradation studies. Lastly, the new easylite-Kinase™ assay is a luminescence platform to detect general kinase activity.
Virtually anything can be measured with Alpha Technology quickly and easily, including enzymes, receptor-ligand interactions, low-affinity interactions, second messenger levels, DNA, RNA, proteins, protein:protein interactions, peptides, sugars and small molecules.
Choose the Alpha solution that’s right for you
Whether you are studying biomarkers, phospho-proteins, cytokines, kinases, protein-protein interactions, GPCRs or epigenetics, HTRF is sure to have a solution for you. HTRF is a no-wash FRET-based technology designed to make your life easier.
From assay development to primary and secondary screening, LANCE Ultra Technology provides researchers with robust and easy-to-use assays adaptable to a variety of targets on a broad range of multimode detectors, with the fastest time-to-results in a commercially-available TR-FRET assay.
LANCE and LANCE (LANthanide Chelate Excitation) Ultra are our TR-FRET (time-resolved fluorescence resonance energy transfer), homogeneous (no wash) technologies. One binding partner of interest is labeled with a donor fluorophore (a LANCE Europium chelate) and a second one is labeled with an acceptor fluorophore (ULight™ dye). Upon excitation at 320-340 nm, energy can be transferred from the donor Europium chelate to the acceptor fluorophore if sufficiently close for FRET (~10 nm). This results in the emission of light detectable at 665 nm.
DELFIA® (Dissociation-Enhanced Lanthanide Fluorescent Immunoassay) TRF technology combines the benefits of Time Resolved Fluorescence (TRF) with the use of lanthanide chelates for a highly sensitive, robust and reproducible assay format. With over 20 years of history, and thousands of publications, DEFLIA is ideal for simple to complex matrices and can be used for both biochemical and cell-based assays.
From immunoassays, to binding and enzymatic studies, to cytotoxicity and cell proliferation assays, our DELFIA TRF assays are sure to provide you with unmatched sensitivity, time and time again.
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The Alpha SureFire® Ultra™ Multiplex phospho-PDGF Receptor β (Tyr751) + Total PDGF Receptor &beta assay kit is used to measure both the phosphorylation (on Tyr751) and total levels of endogenous PDGF Receptor β in cellular lysates. The assay is an ideal system for the screening of modulators of receptor activation (e.g. agonists and antagonists) as well as agents acting intracellularly, such as small molecule inhibitors of signal transduction. The assay will measure PDGF Receptor β phosphorylation by either recombinant or endogenous receptors and can be applied to primary cells.
The AlphaLISA® mouse Interleukin-3 (IL-3) Detection Kit is designed for detection and quantitation of mouse IL-3 in buffered solution, or cell culture in a homogeneous AlphaLISA assay (no wash steps).
The AlphaLISA® SureFire® Ultra™ total FGF Receptor 3 assay is a sandwich immunoassay for quantitative detection of FGF Receptor 3 (phosphorylated and non-phosphorylated) in cellular lysates using Alpha Technology. This assay is intended to be a normalization phosphorylation studies.
The AlphaLISA® SureFire® Ultra™ total c-myc assay is a sandwich immunoassay for quantitative detection of c-myc (phosphorylated and non-phosphorylated) in cellular lysates using Alpha Technology. This assay is intended to be a normalization phosphorylation studies.
The AlphaLISA® human CD28/CD86 binding kit is designed for the detection of binding activity between human CD28 and CD86, using a fast and simple homogeneous AlphaLISA assay (no wash steps). This assay can be used to screen for small molecules that inhibit binding, as a competitive ligand binding (CLB) assay to screen therapeutic blocking antibodies, and for potency assays.
The AlphaLISA® SureFire® Ultra™ total STAT1 assay is a sandwich immunoassay for quantitative detection of STAT1 (phosphorylated and non-phosphorylated) in cellular lysates using Alpha Technology. This assay is intended to be a normalization phosphorylation studies.
The AlphaLISA® SureFire® Ultra™ total eiF4E assay is a sandwich immunoassay for quantitative detection of eiF4E (phosphorylated and non-phosphorylated) in cellular lysates using Alpha Technology. This assay is intended to be a normalization phosphorylation studies.
The AlphaLISA® SureFire® Ultra™ p-Rb (S780) assay is a sandwich immunoassay for quantitative detection of phospho-Rb (phosphorylated on S780) in cellular lysates using Alpha Technology.
The AlphaLISA® SureFire® Ultra™ p-Raf-1 (Ser338) assay is a sandwich immunoassay for quantitative detection of phospho-Raf-1 (phosphorylated on Ser338) in cellular lysates using Alpha Technology.
The AlphaLISA® SureFire® Ultra™ total Acetyl CoA carboxylase assay is a sandwich immunoassay for quantitative detection of Acetyl CoA carboxylase (phosphorylated and non-phosphorylated) in cellular lysates using Alpha Technology. This assay is intended to be a normalization phosphorylation studies.
The AlphaLISA® SureFire® Ultra™ p-KAP1 (S824) assay is a sandwich immunoassay for quantitative detection of phospho-KAP1 (phosphorylated on S824) in cellular lysates using Alpha Technology.
Measure binding of small molecule drug candidates to target protein in a cellular environment with Alpha SureFire® CETSA® target engagement assays. For use in combination with Pelago Bioscience's CETSA® (Cellular Thermal Shift Assay) technology, this kit provides a convenient no-wash assay for detection and quantitation of small molecule binding to CDK4, and can be used in hit identification, hit confirmation, and lead optimization studies for increased confidence and better prediction early in the drug discovery process. Please note that a valid CETSA® subscription from Pelago Biosciences is required for use.
The AlphaLISA® SureFire® Ultra™ p-c-Myc (Ser62) assay is a sandwich immunoassay for quantitative detection of phospho-c-Myc (phosphorylated on Ser62) in cellular lysates using Alpha Technology.
The AlphaLISA® SureFire® Ultra™ total FGF Receptor 2 assay is a sandwich immunoassay for quantitative detection of FGF Receptor 2 (phosphorylated and non-phosphorylated) in cellular lysates using Alpha Technology. This assay is intended to be a normalization phosphorylation studies.
Measure binding of small molecule drug candidates to target protein in a cellular environment with Alpha SureFire® CETSA® target engagement assays. For use in combination with Pelago Bioscience's CETSA® (Cellular Thermal Shift Assay) technology, this kit provides a convenient no-wash assay for detection and quantitation of small molecule binding to CDK2, and can be used in hit identification, hit confirmation, and lead optimization studies for increased confidence and better prediction early in the drug discovery process. Please note that a valid CETSA® subscription from Pelago Biosciences is required for use.
The AlphaLISA® SureFire® Ultra™ p-FGF Receptor 2 (Y653/654) assay is a sandwich immunoassay for quantitative detection of phospho-FGF Receptor 2 (phosphorylated on Y653/654) in cellular lysates using Alpha Technology.
The AlphaLISA® SureFire® Ultra™ p-c-Myc (Thr58) assay is a sandwich immunoassay for quantitative detection of phospho-c-Myc (phosphorylated on Thr58) in cellular lysates using Alpha Technology.
The AlphaLISA® SureFire® Ultra™ p-TBK1 (Ser172) assay is a sandwich immunoassay for quantitative detection of phospho-TBK1 (phosphorylated on Ser172) in cellular lysates using Alpha Technology.
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