Many scientists have pointed to the importance of inflammation on disease progression, and evidence suggests that chronic inflammation is a staple feature of complex neurological disorders such as neurodegeneration. Neuroinflammation is thought to play a key role in diseases such as Alzheimer’s and Parkinson’s due to the promotion of various pro-inflammatory mediators and pathways. These can elicit detrimental effects on typically homeostatic processes that maintain the health of the brain and blood-brain barrier by cells such as microglia and astrocytes.
We offer a wide variety of reagents and kits readable on the VICTOR® Nivo™ or EnVision® multimode plate readers for high-throughput detection of cytokines and interleukins such as TNF-α, IL-1β, and IL-6; corresponding downstream kinase pathways; various neurotrophic factors such as BDNF; and proteins such as TREM2, SYK, and phospho ubiquitin Ser65. This is of great importance due to their involvement in processes such as oxidative stress response, mitophagy, and phagocytosis that modulate neuroprotection and neuronal health affected by chronic neuroinflammation.