PerkinElmer

Neuroinflammation

Many scientists have pointed to the importance of inflammation on disease progression, and evidence suggests that chronic inflammation is a staple feature of complex neurological disorders such as neurodegeneration. Neuroinflammation is thought to play a key role in diseases such as Alzheimer’s and Parkinson’s due to the promotion of various pro-inflammatory mediators and pathways. These can elicit detrimental effects on typically homeostatic processes that maintain the health of the brain and blood-brain barrier by cells such as microglia and astrocytes.

We offer a wide variety of reagents and kits readable on the VICTOR® Nivo or EnVision® multimode plate readers for high-throughput detection of cytokines and interleukins such as TNF-α, IL-1β, and IL-6; corresponding downstream kinase pathways; various neurotrophic factors such as BDNF; and proteins such as TREM2, SYK, and phospho ubiquitin Ser65. This is of great importance due to their involvement in processes such as oxidative stress response, mitophagy, and phagocytosis that modulate neuroprotection and neuronal health affected by chronic neuroinflammation.

Explore our Solutions and Products

Microplate Readers

Performance, Versatility, and Reliability for Today’s Laboratory Needs As many of you know, microplate readers are instruments used to detect biological, chemic ...

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Cytokine Research Reagents

Cytokines regulate several physiological and pathological roles including innate immunity, acquired immunity, and many inflammatory responses. PerkinElmer offer ...

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Inflammation

Inflammation is a natural marker for bodily health, and abnormal inflammatory response is indicated in an increasingly wide net of diseases and disorders, from ...

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IVIS Spectrum In Vivo Imaging System

The IVIS® Spectrum in vivo imaging system combines 2D optical and 3D optical tomography in one platform. The system uses leading optical technology for preclini ...

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TNFα (human) AlphaLISA Biotin-Free Detection Kit, 100 Assay Points

The AlphaLISA Human TNFα Biotin-Free Detection Kit is designed for the quantitative detection of human TNFα in serum, cell culture medium, and other samples typ ...

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IL-6 (human) AlphaLISA Biotin-free Detection Kit, 100 Assay Points

The AlphaLISA Human IL-6 Biotin-Free Detection Kit is designed for the quantitative detection of human IL-6 in serum, cell culture medium, and other samples typ ...

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