PerkinElmer

Metabolic Disease

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Metabolic diseases like diabetes are increasingly widespread, and research for this class of diseases relies on discovering and quantifying biomarkers to elucidate underlying mechanisms and uncover novel drug targets. Our portfolio of metabolic assays are well suited for metabolic disease research in vitro, in vivo, and in situ, and offer novel tools for your research workflow from start to finish.

Metabolic diseases are systemic and manifest with a variety of biological changes, from autophagy dysfunction to altered blood coagulation. For easy detection of a wide range of metabolic biomarkers, we offer fast and pre-validated metabolic assay reagents, kits, and imaging systems. For targeted binding studies, we also provide target-specific radiolabeled reagents.

Our products for metabolic disease research include:

  • LANCE® TR-FRET technology
  • AlphaLISA® immunoassay kits
  • Alpha reagents for AlphaLISA
  • DELFIA® TRF technology
  • Cellular, tissue, and in vivo imaging systems
  • Target-specific radiolabeled ligands, carbohydrates, lipids, and steroids

The range of tools offered allows for the detection and quantitation of many key biomolecules in metabolic disease research. Gain precise insight on disease biomarkers like c-reactive protein, fibrinogen, IGF, FGF, insulin and glucagon, leptin and ghrelin, adiponectin, and factor VIII.

Products & Services (135)
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Product Type
  • Instruments (1)
  • Reagents (130)
  • Software and Informatics (4)
Assay Target
  • Adiponectin (3)
  • Albumin (5)
  • ApoA1 (4)
  • ApoB (2)
  • ApoC3 (2)
  • ApoE (2)
  • AST (1)
  • BMP-9 (1)
  • C-peptide (2)
  • CCL2 (1)
  • Corticosterone (2)
  • Cortisol (3)
  • CYCS (1)
  • Factor VIII (1)
  • FSH (3)
  • Ghrelin (4)
  • GLP-1 (2)
  • Glucagon (3)
  • Growth Hormone (1)
  • hCG (3)
  • HO-1 (1)
  • HO-2 (1)
  • IGF1 (5)
  • IGF2 (1)
  • Insulin (4)
  • KIM-1 (1)
  • LDH (1)
  • Leptin (5)
  • MANF (2)
  • MBNL1 (1)
  • NNMT (1)
  • Osteoprotegerin (2)
  • PCSK9 (1)
  • PIGF (1)
  • PON1 (1)
  • PON2 (1)
  • Progesterone (1)
  • PSMA (2)
  • SHP2 (1)
  • Somatostatin (1)
  • Testosterone (1)
  • TSH (4)
  • Utrophin (1)
Target Species
  • Human (78)
  • Mouse (5)
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Application
  • Protein Analysis & Detection (84)
Therapeutic Area
  • Angiogenesis (1)
  • Biologics/Bioprocess (4)
  • Cancer (4)
  • Central Nervous System (1)
  • Inflammation (5)
  • Metabolic (63)
Product Brand Name
  • AlphaLISA (55)
  • AlphaPlex (2)
  • LANCE Ultra (28)
  • Membrane Target Systems (1)
  • NEN Radiochemicals (42)
  • Quantum (1)
Detection Method
  • Alpha (57)
  • Radiometric (43)
  • Time-Resolved Fluorescence (TRF) (25)
  • TR-FRET (25)
Receptor Type
  • Ghrelin (1)
Assay Validated
  • Binding (1)
Radioisotope
  • C-14 (22)
  • H-3 (21)
Radionuclide
  • 14C (22)
  • 3H (21)
Label Position
  • Generally Labeled (2)
  • Nominally Labeled (12)
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  • Aqueous (9)
  • Aqueous PT6-271 Stabilizer (1)
  • Ethanol : water (9)
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  • 100 (29)
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  • Cytokine (1)
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  • Hormone (37)
  • Peptide (5)
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Automation Compatible
  • Yes (86)
Concentration
  • 0.02 mCi/mL (1)
  • 0.05 mCi/mL (1)
  • 0.1 mCi/mL (9)
  • 0.2 mCi/mL (4)
  • 1 mCi/mL (14)
Experimental Type
  • In vitro (71)
Format
  • Microplates (68)
Host Cell
  • CHO-K1 (1)
Imaging Modality
  • microCT Imaging (1)
Length
  • 901-1000 (1)
Volume
  • 0-50 (11)
  • 201-250 (4)

1-12 of 135 Products & Services

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  • Quantum GX2 microCT imaging system

    Quantum GX2 microCT Imaging System

    Image beyond bone – into oncology, cardiovascular and pulmonary diseases, and much more, with the Quantum GX2 microCT imaging system. With the Quantum GX2, flexibility is key. Combining the ability to perform high speed, low dose scans, ideal for longitudinal studies, across multiple species (mice, rats, rabbits) with high resolution ex vivo scanning, the Quantum GX2 microCT imaging system offers the flexibility and performance you need to not just image, but further understand your disease models.
  • AlphaLISA immunoassay kits

    Somatostatin (human) AlphaLISA Detection Kit

    The AlphaLISA® Somatostatin Detection Kit is designed for detection and quantitation of somatostatin in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.
    Price Range : 725.00 USD - 10500.00 USD
  • AlphaLISA immunoassay kits

    Testosterone AlphaLISA Detection Kit

    The AlphaLISA® Testosterone Research Kit is designed for detection and quantitation of testosterone in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.
    Price Range : 672.00 USD - 10500.00 USD
  • LANCE Detection Kit

    PCSK9 (human) LANCE Ultra TR-FRET Detection Kit

    The LANCE® Ultra Human PCSK9 Detection Kit is designed for detection and quantitation of human Proprotein Convertase Subtilisin/Kexin Type 9 in cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.
    Price Range : 829.00 USD - 11100.00 USD
  • C-peptide (human) AlphaLISA Kit

    AlphaLISA® no-wash immunoassay kit for detection of human C-peptide (human connecting peptide) in serum, buffered solution or cell culture medium.
    Price Range : 1539.00 USD - 10200.00 USD
  • Adenosine 5 Triphosphate 250 µCi

    Glucose, 3-O-[Methyl-D-1-3H]

    3-O-Methyl-D-Glucose is a non-metabolizable glucose analogue that is not phosphorylated by hexokinase. 3-O-Methylglucose is used as a marker to assess glucose transport by evaluating its uptake within various cells and organ systems.
    List Price : 1348.00 USD
  • AlphaLISA assay principle

    Total Ghrelin (human) AlphaLISA Detection Kit

    The AlphaLISA® immunoassay kit for human total ghrelin enables the quantitative determination of total ghrelin in serum, plasma, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
    Price Range : 625.00 USD - 18800.00 USD
  • LANCE Detection Kit

    FSH (human) LANCE Ultra TR-FRET Detection Kit

    The LANCE® Ultra Human Follicle Stimulating Hormone (FSH) Detection Kit is designed for detection and quantitation of human FSH in buffered solution and cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.
    Price Range : 806.00 USD - 10700.00 USD
  • Protein

    Glucagon (human), liquid (LANCE)

    Human glucagon standard, liquid, for use in running standard curves in LANCE TR-FRET no-wash detection assays. This standard is already provided in the LANCE Ultra Human Glucagon TR-FRET Detection Kit, but can be ordered separately.
    List Price : 250.00 USD
  • Diclofenac sodium- Phenylacetic acid C14

    Glucose, D-[1-14C]

    D-glucose, labeled with C-14. D-glucose can be incorporated into lipds, and provides a measurement of glucose transport. It is a metabolized tracer in glucose uptake studies.
    Price Range : 747.00 USD - 4211.00 USD
  • Deoxy-D-glucose, 2-[14C(U)]

    2-Deoxy-D-glucose, labeled uniformly with carbon-14. This product is supplied steri-packaged in an aqueous solution. Deoxy-D-glucose (DOG) is a glucose analog that is readily transported into most cells, is phosphorylated and trapped by the cells (unidirectional transport), and cannot be further metabolized. It is the most-common chemical used in glucose uptake assays.
    Price Range : 1070.00 USD - 2427.00 USD
  • Adenosine 5 Triphosphate 250 µCi

    Myo-inositol, [3H], 1 mCi

    Myo-inositol, [3H]- will have fresh lot dates on the second Monday in March and September.
    List Price : 3261.00 USD
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Business Insights (3)
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1-3 of 3 Business Insights

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  • White Paper

    Streamlining Materials Innovation Processes with Electronic Lab Notebook (ELN) and Data Analytics for Optimum Efficiency

    This paper explores the numerous challenges materials scientists and engineers face, from the time it takes to bring new materials to market to the difficulties delivering suitable formulations and testing against specified criteria, and how those can be resolved.

  • Application Note

    Contrast-enhanced Imaging of Vasculature and Soft Tissues Using the Quantum GX MicroCT System

    X-ray CT imaging is commonly used for skeletal imaging as bones are densely mineralized tissues with excellent x-ray attenuation properties. In contrast, soft, less dense tissues often prove to be challenging to image due to their lack of sufficient tissue density. Soft tissues such as muscle, blood vessels and internal organs share similar x-ray attenuation characteristics and are not distinguishable under typical CT settings. In order to introduce density that would improve soft tissue contrast, several contrast agents have been developed for use in clinical and preclinical settings. This application note outlines the use of iodine and nanoparticle-based contrast agents for imaging soft tissues and vasculature in various organs using the Quantum GX to gain further insights into disease and therapeutic response.

  • Application Note

    MicroCT Investigation of Bone Erosion and Deformation in an Osteoarthritic Rat Model

    Osteoarthritis (OA) is the most common form of arthritis and affects a considerable portion of the elderly population. In the U.S., it is estimated that more than 630 million people worldwide have this chronic condition, generally in the knees. OA occurs when the cartilage that cushions the ends of bones within the joints gradually deteriorates, causing synovitis and joint deformation.

    The goal of OA research is to identify new therapeutic strategies that could prevent, reduce, halt progression, or repair the existing damage to the joint. Non-invasive in vivo imaging such as microCT is the standard modality for bone research due to its ability to obtain high-resolution images at an x-ray dose low enough as not to harm the animal. This makes microCT ideal for monitoring disease progression and response to treatments in the same animal over time. However, microCT data visualization and analysis can be cumbersome and time consuming. In this application note, we compared standard microCT software and advanced bone software to investigate bone erosion in an OA rat model.