Metabolic Disease

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Metabolic diseases like diabetes are increasingly widespread, and research for this class of diseases relies on discovering and quantifying biomarkers to elucidate underlying mechanisms and uncover novel drug targets. Our portfolio of metabolic assays are well suited for metabolic disease research in vitro, in vivo, and in situ, and offer novel tools for your research workflow from start to finish.

Metabolic diseases are systemic and manifest with a variety of biological changes, from autophagy dysfunction to altered blood coagulation. For easy detection of a wide range of metabolic biomarkers, we offer fast and pre-validated metabolic assay reagents, kits, and imaging systems. For targeted binding studies, we also provide target-specific radiolabeled reagents.

Our products for metabolic disease research include:

LANCE^® TR-FRET technology
AlphaLISA^® immunoassay kits
Alpha reagents for AlphaLISA
DELFIA^® TRF technology
Cellular, tissue, and in vivo imaging systems
Target-specific radiolabeled ligands, carbohydrates, lipids, and steroids

The range of tools offered allows for the detection and quantitation of many key biomolecules in metabolic disease research. Gain precise insight on disease biomarkers like c-reactive protein, fibrinogen, IGF, FGF, insulin and glucagon, leptin and ghrelin, adiponectin, and factor VIII.

Products & Services (127)
Technical Resources (176)
Tools & More (13)
Business Insights (4)

Products & Services (127)

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Product Type

Instruments (1)
Reagents (123)
Software and Informatics (3)

Assay Target

Acetyl CoA carboxylase (1)
Adiponectin (3)
Albumin (5)
AMPKα1/2 (1)
ApoA1 (4)
ApoB (2)
ApoC3 (2)
ApoE (2)
AST (1)
BMP-9 (1)
C-peptide (2)
CCL2 (1)
Corticosterone (2)
Cortisol (3)
Factor VIII (1)
FSH (3)
Ghrelin (4)
GLP-1 (2)
Glucagon (3)
Growth Hormone (1)
hCG (3)
HO-1 (1)
HO-2 (1)
IGF1 (5)
IGF2 (1)
Insulin (4)
KIM-1 (1)
LDH (1)
Leptin (5)
MANF (2)
MBNL1 (1)
NNMT (1)
Osteoprotegerin (1)
PCSK9 (1)
PIGF (1)
PON1 (1)
PON2 (1)
Progesterone (1)
SHP2 (1)
Testosterone (1)
TSH (4)

Application

Protein Analysis & Detection (80)

Therapeutic Area

Angiogenesis (1)
Biologics/Bioprocess (4)
Cancer (2)
Inflammation (4)
Metabolic (61)
Metabolism (2)

Product Brand Name

Alpha SureFire Ultra Multiplex (1)
AlphaLISA (49)
AlphaLISA SureFire Ultra (1)
AlphaPlex (2)
LANCE Ultra (28)
Membrane Target Systems (1)
NEN Radiochemicals (39)
Quantum (1)

Detection Method

Alpha (53)
Radiometric (40)
Time-Resolved Fluorescence (TRF) (25)
TR-FRET (25)

Receptor Type

Ghrelin (1)

Assay Validated

Binding (1)

Radioisotope

C-14 (22)
H-3 (18)

Radionuclide

¹⁴C (22)
³H (18)

Label Position

Generally Labeled (1)
Nominally Labeled (12)
Specifically Labeled (18)
Uniformly Labeled (9)

Assay Points (200-50,000)

100 (28)
10000 (18)
500 (55)
5000 (38)
50000 (2)

Assay Target Class

Cytokine (1)
GPCR (1)
Hormone (35)
Peptide (4)
Phosphoprotein (1)
Protein (42)

Automation Compatible

Yes (82)

Concentration

0.02 mCi/mL (1)
0.05 mCi/mL (1)
0.1 mCi/mL (9)
0.2 mCi/mL (4)
1 mCi/mL (13)

Experimental Type

In vitro (70)

Format

Microplates (63)

Host Cell

CHO-K1 (1)

Imaging Modality

microCT Imaging (1)

Volume

0-50 (10)
201-250 (4)

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1-25 of 127 Products & Services

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Quantum GX2 microCT Imaging System

CLS149276

Image beyond bone – into oncology, cardiovascular and pulmonary diseases, and much more, with the Quantum GX2 microCT imaging system. With the Quantum GX2, flexibility is key. Combining the ability to perform high speed, low dose scans, ideal for longitudinal studies, across multiple species (mice, rats, rabbits) with high resolution ex vivo scanning, the Quantum GX2 microCT imaging system offers the flexibility and performance you need to not just image, but further understand your disease models.
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Deoxy-D-glucose, 2-[1,2-³H(N)]

NET549A005MC , NET549A001MC , NET549A250UC

2-Deoxy-D-glucose, labeled with tritium at C1/C2. Deoxy-D-glucose (DOG) is a glucose analog that is readily transported into most cells, is phosphorylated and trapped by the cells (unidirectional transport), and cannot be further metabolized. It is the most-common chemical used in glucose uptake assays.

Price Range : 875.00 USD - 3673.00 USD
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Alpha SureFire Ultra Multiplex phospho/total AMPKα1/2 Assay Kit

MPSU-PTAMPK-K10K , MPSU-PTAMPK-K500 , MPSU-PTAMPK-K-HV , MPSU-PTAMPK-K50K

The Alpha SureFire® Ultra™ Multiplex phospho AMPKα1/2 (Thr172) + Total AMPKα1/2 assay kit is used to measure both the phosphorylation (on Thr172) and total levels of endogenous AMPKα1/2 in cellular lysates. The assay is an ideal system for the screening of modulators of receptor activation (e.g. agonists and antagonists) as well as agents acting intracellularly, such as small molecule inhibitors of signal transduction. The assay will measure AMPKα1/2 phosphorylation by either recombinant or endogenous receptors and can be applied to primary cells.
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Glucose, D-[1-¹⁴C]

NEC043X001MC , NEC043X250UC , NEC043X050UC

D-glucose, labeled with C-14. D-glucose can be incorporated into lipds, and provides a measurement of glucose transport. It is a metabolized tracer in glucose uptake studies.

Price Range : 824.00 USD - 4649.00 USD
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IGF-1 (rat) AlphaLISA Detection Kit

AL552HV , AL552F , AL552C

The AlphaLISA^® immunoassay kit for rat IGF-1 enables the quantitative determination of rat insulin-like growth factor 1 (IGF-1) in serum, buffered solution, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).

Price Range : 715.00 USD - 21400.00 USD
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Testosterone AlphaLISA Detection Kit

AL324F , AL324HV , AL324C

The AlphaLISA^® Testosterone Research Kit is designed for detection and quantitation of testosterone in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.

Price Range : 768.00 USD - 12000.00 USD
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Glucose, D-[5-³H(N)]

NET531001MC

D-glucose, labeled with tritium. D-glucose can be incorporated into lipds, and provides a measurement of glucose transport. It is a metabolized tracer in glucose uptake studies.

List Price : 1805.00 USD
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Apo-CIII (human) LANCE Ultra TR-FRET Detection Kit

TRF1396M , TRF1396C

The LANCE® Ultra Human Apo-CIII Detection Kit is designed for detection and quantitation of ApoC3 in buffered solution and cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.

Price Range : 840.00 USD - 11200.00 USD
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TSH (human) LANCE Ultra TR-FRET Detection Kit

TRF3005C , TRF3005M

The LANCE^® Ultra Human TSH Detection Kit is designed for detection and quantitation of human thyroid stimulating hormone in buffered solution and cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.

Price Range : 865.00 USD - 11500.00 USD
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ApoA1 (human) AlphaLISA Detection Kit

AL389C , AL389HV , AL389F

The AlphaLISA^® immunoassay kit for ApoA1 is designed for the quantitative determination of ApoA1 in human serum, human plasma and cell supernantants using a homogeneous AlphaLISA assay (no wash steps). Neglible cross reactivity was observed with ApoCIII, ApoE, or ApoB.

Price Range : 736.00 USD - 22100.00 USD
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Uridine diphospho-D-glucose, [6-³H]-, 250 µCi

NET1163250UC

250 µCi quantities of [6-³H]-Uridine Diphospho-D-Glucose are available for your research.

List Price : 2628.00 USD
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Progesterone AlphaLISA Detection Kit

AL335C , AL335HV , AL335F

The AlphaLISA^® Progesterone Detection Kit is designed for detection and quantitation of progesterone in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.

Price Range : 828.00 USD - 12000.00 USD
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Total Ghrelin (human) AlphaLISA Detection Kit

AL3012C , AL3012F , AL3012HV

The AlphaLISA® immunoassay kit for human total ghrelin enables the quantitative determination of total ghrelin in serum, plasma, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).

Price Range : 715.00 USD - 21400.00 USD
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Deoxy-D-glucose, 2-[1,2-3H (N)]-, EtOH Sol, Specific Activity: 5-10 Ci (185-370 GBq)/mmol

NET328001MC , NET328250UC

2-Deoxy-D-glucose, nominally labeled with tritium at C1/C2. This product is supplied in 90% ethanol. Deoxy-D-glucose (DOG) is a glucose analog that is readily transported into most cells, is phosphorylated and trapped by the cells (unidirectional transport), and cannot be further metabolized. It is the most-common chemical used in glucose uptake assays.

Price Range : 840.00 USD - 1315.00 USD
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Inositol, Myo, -[2-3H(N)]-, EtOH Sol, Specific Activity: 10-25 Ci (370-925 GBq)/mmol

NET114005MC , NET114001MC

Myo-inositol, labeled with tritium. This product is supplied in 90% ethanol. Tritiated myoinositol is commonly used to label lipids.

Price Range : 2168.00 USD - 5400.00 USD
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Galactose, D-[1-¹⁴C]

NEC302X050UC

50 µCi quantities of D-[1-¹⁴C]-Galactose are available for your research.

List Price : 1636.00 USD
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Leptin (mouse), lyophilized (LANCE)

TRF1521S

Mouse leptin standard, lyophilized, for use in running standard curves in LANCE Ultra TR-FRET assays. This standard is already provided in the LANCE Ultra Mouse Leptin Detection Kit, but can be ordered separately.

List Price : 261.00 USD
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Corticosterone (human) AlphaLISA Detection Kit

AL3020F , AL3020HV , AL3020C

The AlphaLISA^® immunoassay kit for human corticosterone enables the quantitative determination of corticosterone in serum, buffered solution, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).

Price Range : 515.00 USD - 11300.00 USD
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TSH (human) AlphaLISA Detection Kit

AL3005C , AL3005F , AL3005HV

The AlphaLISA^® immunoassay kit for human TSH enables the quantitative determination of human thyroid stimulating hormone (TSH) in serum, buffered solution, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).

Price Range : 736.00 USD - 22100.00 USD
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C-Peptide (mouse/rat) AlphaLISA Detection Kit

AL510F , AL510C

The AlphaLISA^® Mouse/Rat Connecting Peptide (C-Peptide) Detection Kit is designed for detection and quantitation of mouse or rat C-Peptide in buffered solution in a homogeneous (no-wash steps, no separation steps) assay.

Price Range : 3470.00 USD - 27100.00 USD
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Sucrose, [¹⁴C(U)]-, Specific Activity: 400-700mCi (14.8-25.9GBq)/mmol

NEC100X050UC , NEC100X001MC , NEC100X250UC

Sucrose, labeled with C-14. ¹⁴C-sucrose is commonly used to study blood-brain barrier permeability.

Price Range : 611.00 USD - 3621.00 USD
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Heme oxygenase 2 AlphaLISA Detection Kit

AL3027F , AL3027C , AL3027HV

The AlphaLISA^® immunoassay kit for human heme oxygenase 2 (HO-2) enables the quantitative determination of human HO-2 in serum, buffered solution, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).

Price Range : 515.00 USD - 11300.00 USD
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Albumin (mouse) AlphaLISA Detection Kit

AL508C , AL508F

The AlphaLISA^® Mouse Albumin Detection Kit is designed for the quantitative detection of mouse albumin in serum, urine, buffered solution or cell culture medium, using a homogeneous (no wash steps, no separation steps) assay.

Price Range : 3470.00 USD - 27100.00 USD
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Insulin (human) AlphaLISA Detection Kit

AL350F , AL350HV , AL350C

The AlphaLISA^® Human Insulin Detection Kit is designed for detection and quantitation of human insulin in cell culture supernatants, serum, and plasma using a homogeneous (no-wash steps, no separation steps) assay.

Price Range : 828.00 USD - 11600.00 USD
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Cortisol LANCE Ultra TR-FRET Detection Kit

TRF1314M , TRF1314C

The LANCE^® Ultra Cortisol Detection Kit is designed for detection and quantitation of cortisol in buffered solution and cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.

Price Range : 1693.00 USD - 11500.00 USD