Metabolic Disease

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Metabolic diseases like diabetes are increasingly widespread, and research for this class of diseases relies on discovering and quantifying biomarkers to elucidate underlying mechanisms and uncover novel drug targets. Our portfolio of metabolic assays are well suited for metabolic disease research in vitro, in vivo, and in situ, and offer novel tools for your research workflow from start to finish.

Metabolic diseases are systemic and manifest with a variety of biological changes, from autophagy dysfunction to altered blood coagulation. For easy detection of a wide range of metabolic biomarkers, we offer fast and pre-validated metabolic assay reagents, kits, and imaging systems. For targeted binding studies, we also provide target-specific radiolabeled reagents.

Our products for metabolic disease research include:

LANCE^® TR-FRET technology
AlphaLISA^® immunoassay kits
Alpha reagents for AlphaLISA
DELFIA^® TRF technology
Cellular, tissue, and in vivo imaging systems
Target-specific radiolabeled ligands, carbohydrates, lipids, and steroids

The range of tools offered allows for the detection and quantitation of many key biomolecules in metabolic disease research. Gain precise insight on disease biomarkers like c-reactive protein, fibrinogen, IGF, FGF, insulin and glucagon, leptin and ghrelin, adiponectin, and factor VIII.

Products & Services (134)
Technical Resources (165)
Tools & More (13)
Business Insights (3)

Products & Services (134)

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Product Type

Instruments (1)
Reagents (129)
Software and Informatics (4)

Assay Target

Adiponectin (3)
Albumin (5)
ApoA1 (4)
ApoB (2)
ApoC3 (2)
ApoE (2)
AST (1)
BMP-9 (1)
C-peptide (2)
CCL2 (1)
Corticosterone (2)
Cortisol (3)
CYCS (1)
Factor VIII (1)
FSH (3)
Ghrelin (4)
GLP-1 (2)
Glucagon (3)
Growth Hormone (1)
hCG (3)
HO-1 (1)
HO-2 (1)
IGF1 (5)
IGF2 (1)
Insulin (4)
KIM-1 (1)
LDH (1)
Leptin (5)
MANF (2)
MBNL1 (1)
NNMT (1)
Osteoprotegerin (1)
PCSK9 (1)
PIGF (1)
PON1 (1)
PON2 (1)
Progesterone (1)
PSMA (2)
SHP2 (1)
Somatostatin (1)
Testosterone (1)
TSH (4)
Utrophin (1)

Target Species

Human (77)
Mouse (5)
Rat (4)

Application

Protein Analysis & Detection (83)

Therapeutic Area

Angiogenesis (1)
Biologics/Bioprocess (4)
Cancer (4)
Central Nervous System (1)
Inflammation (4)
Metabolic (63)

Product Brand Name

AlphaLISA (54)
AlphaPlex (2)
LANCE Ultra (28)
Membrane Target Systems (1)
NEN Radiochemicals (42)
Quantum (1)

Detection Method

Alpha (56)
Radiometric (43)
Time-Resolved Fluorescence (TRF) (25)
TR-FRET (25)

Receptor Type

Ghrelin (1)

Assay Validated

Binding (1)

Radioisotope

C-14 (22)
H-3 (21)

Radionuclide

¹⁴C (22)
³H (21)

Label Position

Generally Labeled (2)
Nominally Labeled (12)
Specifically Labeled (20)
Uniformly Labeled (9)

Buffer

Aqueous (9)
Aqueous PT6-271 Stabilizer (1)
Ethanol : water (9)

Assay Points (200-50,000)

100 (29)
10000 (16)
500 (56)
5000 (41)

Assay Target Class

Cytokine (1)
GPCR (1)
Hormone (37)
Peptide (5)
Protein (43)

Automation Compatible

Yes (85)

Concentration

0.02 mCi/mL (1)
0.05 mCi/mL (1)
0.1 mCi/mL (9)
0.2 mCi/mL (4)
1 mCi/mL (14)

Experimental Type

In vitro (70)

Format

Microplates (67)

Host Cell

CHO-K1 (1)

Imaging Modality

microCT Imaging (1)

Volume

0-50 (11)
201-250 (4)

1-25 of 134 Products & Services

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Quantum GX2 microCT Imaging System

CLS149276

Image beyond bone – into oncology, cardiovascular and pulmonary diseases, and much more, with the Quantum GX2 microCT imaging system. With the Quantum GX2, flexibility is key. Combining the ability to perform high speed, low dose scans, ideal for longitudinal studies, across multiple species (mice, rats, rabbits) with high resolution ex vivo scanning, the Quantum GX2 microCT imaging system offers the flexibility and performance you need to not just image, but further understand your disease models.
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PCSK9 (human) LANCE Ultra TR-FRET Detection Kit

TRF1270C , TRF1270M

The LANCE^® Ultra Human PCSK9 Detection Kit is designed for detection and quantitation of human Proprotein Convertase Subtilisin/Kexin Type 9 in cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.

Price Range : 829.00 USD - 11100.00 USD
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Glucosamine, N-Acetyl-D - [1-¹⁴C]

NEC723V050UC

50 µCi quantities of N-Acetyl-D-[1-¹⁴C]-Glucosamine are available for your research.

List Price : 2173.00 USD
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Glucose, D-[5-³H(N)]

NET531001MC , NET531005MC

D-glucose, labeled with tritium. D-glucose can be incorporated into lipds, and provides a measurement of glucose transport. It is a metabolized tracer in glucose uptake studies.

Price Range : 1635.00 USD - 3818.00 USD
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Glucose, D-[3-3H]-, Aqueous Sol, Specific Activity: 10-20 Ci (370-740 GBq)/mmol

NET331A005MC , NET331A001MC , NET331A250UC

D-glucose, labeled with tritium at C3. This product is supplied steri-packaged in an aqueous solution. Specifically-labeled glucose can be used for metabolic studies and glucose uptake.

Price Range : 778.00 USD - 3468.00 USD
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CITRIC ACID, [1,5-14C]-, EtOH Sol

NEC160050UC , NEC160250UC

Citric acid, labeled with C-14 at C1 and C5. ¹⁴C-citrate is commonly used to label long-chain fatty acids.

Price Range : 980.00 USD - 3515.00 USD
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Mannose, D-[2-³H(N)]-, Specific Activity: 15-30Ci (555GBq-1.11TBq)/mmol, 5mCi (185MBq)

NET570A005MC

5 mCi quantities of D-[2-³H(N)]-Mannose are available for your research.

List Price : 3701.00 USD
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TSH (human) LANCE Ultra TR-FRET Detection Kit

TRF3005M , TRF3005C

The LANCE^® Ultra Human TSH Detection Kit is designed for detection and quantitation of human thyroid stimulating hormone in buffered solution and cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.

Price Range : 830.00 USD - 11100.00 USD
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Deoxy-D-glucose, 2-[1,2-3H (N)]-, Aqueous Sol, Specific Activity: 5-10 Ci (185-370 GBq)/mmol

NET328A250UC , NET328A001MC

2-Deoxy-D-glucose, nominally labeled with tritium at C1/C2. This product is supplied steri-packaged in an aqueous solution. Deoxy-D-glucose (DOG) is a glucose analog that is readily transported into most cells, is phosphorylated and trapped by the cells (unidirectional transport), and cannot be further metabolized. It is the most-common chemical used in glucose uptake assays.

Price Range : 761.00 USD - 1192.00 USD
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Leptin (mouse) AlphaLISA Detection Kit

AL521F , AL521C

The AlphaLISA^® Mouse Leptin Detection Kit is designed for detection and quantitation of mouse leptin in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.

Price Range : 1539.00 USD - 10200.00 USD
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Inulin, Carboxyl-, [Carboxyl-¹⁴C]

NEC164A050UC , NEC164A250UC

Inulin-carboxyl, labeled on carboxyl groups with C-14. Inulin-carboxyl-14C is commonly used in renal cearance studies.

Price Range : 599.00 USD - 2970.00 USD
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Deoxy-D-glucose, 2-[1,2-³H(N)]

NET549A250UC , NET549A001MC , NET549A005MC

2-Deoxy-D-glucose, labeled with tritium at C1/C2. Deoxy-D-glucose (DOG) is a glucose analog that is readily transported into most cells, is phosphorylated and trapped by the cells (unidirectional transport), and cannot be further metabolized. It is the most-common chemical used in glucose uptake assays.

Price Range : 792.00 USD - 3327.00 USD
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Testosterone AlphaLISA Detection Kit

AL324C , AL324F , AL324HV

The AlphaLISA^® Testosterone Research Kit is designed for detection and quantitation of testosterone in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.

Price Range : 672.00 USD - 10500.00 USD
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Utrophin (human) AlphaLISA Detection Kit

AL3004HV , AL3004C , AL3004F

The AlphaLISA^® immunoassay kit for human utrophin enables the quantitative determination of utrophin in serum, buffered solution, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).

Price Range : 301.00 USD - 18800.00 USD
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Osteoprotegerin (human) AlphaLISA Detection Kit

AL3010HV , AL3010C , AL3010F

The AlphaLISA^® immunoassay kit for total osteoprotegerin enables the quantitative determination of human osteoprotegerin in human serum, plasma, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).

Price Range : 644.00 USD - 19300.00 USD
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Corticosterone (human) AlphaLISA Detection Kit

AL3020HV , AL3020F , AL3020C

The AlphaLISA^® immunoassay kit for human corticosterone enables the quantitative determination of corticosterone in serum, buffered solution, and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).

Price Range : 451.00 USD - 9900.00 USD
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Glucose, D-[2-³H]

NET238C005MC , NET238C001MC

D-glucose, labeled with tritium. D-glucose can be incorporated into lipds, and provides a measurement of glucose transport. It is a metabolized tracer in glucose uptake studies.

Price Range : 1012.00 USD - 3132.00 USD
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Galactose 1-Phosphate, D-[¹⁴C(U)]

NEC579010UC , NEC579050UC

D-galactose 1-phosphate, labeled uniformly with carbon-14. This product is typically used in galactose metabolism studies.

Price Range : 1054.00 USD - 2727.00 USD
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Glucose, D-[3-3H]-, EtOH Sol, Specific Activity: 10-20 Ci (370-740 GBq)/mmol

NET331C250UC , NET331C001MC , NET331C005MC

D-glucose, labeled with tritium at C3. This product is supplied in 90% ethanol. Specifically-labeled glucose can be used for metabolic studies and glucose uptake.

Price Range : 788.00 USD - 3651.00 USD
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ApoE (human) LANCE Ultra TR-FRET Detection Kit

TRF1395M , TRF1395C

The LANCE® Ultra Human ApoE Detection Kit is designed for detection and quantitation of human Apolipoprotein E (ApoE) in buffered solution and cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.

Price Range : 806.00 USD - 10700.00 USD
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FSH (human) LANCE Ultra TR-FRET Detection Kit

TRF1394M , TRF1394C

The LANCE® Ultra Human Follicle Stimulating Hormone (FSH) Detection Kit is designed for detection and quantitation of human FSH in buffered solution and cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.

Price Range : 806.00 USD - 10700.00 USD
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PSMA (human) AlphaLISA Detection Kit

AL3038F , AL3038C , AL3038HV

The AlphaLISA^® immunoassay kit for human PSMA enables the quantitative determination of human prostate specific membrane antigen (PSMA) in buffered solution and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).

Price Range : 625.00 USD - 15000.00 USD
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AlphaPlex™ 545 Human Insulin Detection Kit

AP204TB-HV , AP204TB-F , AP204TB-C

The AlphaPlex™ 545 (Terbium) Human Insulin Detection Kit is designed for the quantitative determination of human Insulin together with another analyte (AlphaLISA) in serum, buffered solution or cell culture medium using a homogeneous assay.

Price Range : 480.00 USD - 10500.00 USD
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Leptin (mouse), lyophilized (LANCE)

TRF1521S

Mouse leptin standard, lyophilized, for use in running standard curves in LANCE Ultra TR-FRET assays. This standard is already provided in the LANCE Ultra Mouse Leptin Detection Kit, but can be ordered separately.

List Price : 250.00 USD
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PON-1 (human) AlphaLISA Detection Kit

AL3071HV , AL3071F , AL3071C

The AlphaLISA^® immunoassay kit for human paraoxonase/arylesterase 1 (PON-1) enables the quantitative determination of human PON-1 in buffered solution, serum, cell culture media, and cell lysates using a homogeneous AlphaLISA assay (no wash steps).

Price Range : 759.00 USD - 14600.00 USD

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