PerkinElmer

Metabolic Disease

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Metabolic diseases like diabetes are increasingly widespread, and research for this class of diseases relies on discovering and quantifying biomarkers to elucidate underlying mechanisms and uncover novel drug targets. Our portfolio of metabolic assays are well suited for metabolic disease research in vitro, in vivo, and in situ, and offer novel tools for your research workflow from start to finish.

Metabolic diseases are systemic and manifest with a variety of biological changes, from autophagy dysfunction to altered blood coagulation. For easy detection of a wide range of metabolic biomarkers, we offer fast and pre-validated metabolic assay reagents, kits, and imaging systems. For targeted binding studies, we also provide target-specific radiolabeled reagents.

Our products for metabolic disease research include:

  • LANCE® TR-FRET technology
  • AlphaLISA® immunoassay kits
  • Alpha reagents for AlphaLISA
  • DELFIA® TRF technology
  • Cellular, tissue, and in vivo imaging systems
  • Target-specific radiolabeled ligands, carbohydrates, lipids, and steroids

The range of tools offered allows for the detection and quantitation of many key biomolecules in metabolic disease research. Gain precise insight on disease biomarkers like c-reactive protein, fibrinogen, IGF, FGF, insulin and glucagon, leptin and ghrelin, adiponectin, and factor VIII.

Products & Services (134)
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Product Type
  • Instruments (1)
  • Reagents (129)
  • Software and Informatics (4)
Assay Target
  • Adiponectin (3)
  • Albumin (5)
  • ApoA1 (4)
  • ApoB (2)
  • ApoC3 (2)
  • ApoE (2)
  • AST (1)
  • BMP-9 (1)
  • C-peptide (2)
  • CCL2 (1)
  • Corticosterone (2)
  • Cortisol (3)
  • CYCS (1)
  • Factor VIII (1)
  • FSH (3)
  • Ghrelin (4)
  • GLP-1 (2)
  • Glucagon (3)
  • Growth Hormone (1)
  • hCG (3)
  • HO-1 (1)
  • HO-2 (1)
  • IGF1 (5)
  • IGF2 (1)
  • Insulin (4)
  • KIM-1 (1)
  • LDH (1)
  • Leptin (5)
  • MANF (2)
  • MBNL1 (1)
  • NNMT (1)
  • Osteoprotegerin (1)
  • PCSK9 (1)
  • PIGF (1)
  • PON1 (1)
  • PON2 (1)
  • Progesterone (1)
  • PSMA (2)
  • SHP2 (1)
  • Somatostatin (1)
  • Testosterone (1)
  • TSH (4)
  • Utrophin (1)
Target Species
  • Human (77)
  • Mouse (5)
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Application
  • Protein Analysis & Detection (83)
Therapeutic Area
  • Angiogenesis (1)
  • Biologics/Bioprocess (4)
  • Cancer (4)
  • Central Nervous System (1)
  • Inflammation (4)
  • Metabolic (63)
Product Brand Name
  • AlphaLISA (54)
  • AlphaPlex (2)
  • LANCE Ultra (28)
  • Membrane Target Systems (1)
  • NEN Radiochemicals (42)
  • Quantum (1)
Detection Method
  • Alpha (56)
  • Radiometric (43)
  • Time-Resolved Fluorescence (TRF) (25)
  • TR-FRET (25)
Receptor Type
  • Ghrelin (1)
Assay Validated
  • Binding (1)
Radioisotope
  • C-14 (22)
  • H-3 (21)
Radionuclide
  • 14C (22)
  • 3H (21)
Label Position
  • Generally Labeled (2)
  • Nominally Labeled (12)
  • Specifically Labeled (20)
  • Uniformly Labeled (9)
Buffer
  • Aqueous (9)
  • Aqueous PT6-271 Stabilizer (1)
  • Ethanol : water (9)
Assay points(200-50,000)
  • 100 (29)
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  • Cytokine (1)
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  • Hormone (37)
  • Peptide (5)
  • Protein (43)
Automation Compatible
  • Yes (85)
Concentration
  • 0.02 mCi/mL (1)
  • 0.05 mCi/mL (1)
  • 0.1 mCi/mL (9)
  • 0.2 mCi/mL (4)
  • 1 mCi/mL (14)
Experimental Type
  • In vitro (70)
Format
  • Microplates (67)
Host Cell
  • CHO-K1 (1)
Imaging Modality
  • microCT Imaging (1)
Length
  • 901-1000 (1)
Volume
  • 0-50 (11)
  • 201-250 (4)

1-12 of 134 Products & Services

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  • Quantum GX2 microCT imaging system

    Quantum GX2 microCT Imaging System

    Image beyond bone – into oncology, cardiovascular and pulmonary diseases, and much more, with the Quantum GX2 microCT imaging system. With the Quantum GX2, flexibility is key. Combining the ability to perform high speed, low dose scans, ideal for longitudinal studies, across multiple species (mice, rats, rabbits) with high resolution ex vivo scanning, the Quantum GX2 microCT imaging system offers the flexibility and performance you need to not just image, but further understand your disease models.
  • LANCE Detection Kit

    Glucagon (human) LANCE Ultra TR-FRET Detection Kit

    The LANCE® Ultra Human Glucagon Detection Kit is designed for detection and quantitation of human glucagon in cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.
    Price Range : 829.00 USD - 11100.00 USD
  • Factor VIII (human) AlphaLISA Detection Kit

    The AlphaLISA® Human VIII Detection Kit is designed for detection and quantitation of human VIII in cell culture media or serum using a homogeneous (no-wash steps, no separation steps) assay.
    Price Range : 672.00 USD - 10500.00 USD
  • Diclofenac sodium- Phenylacetic acid C14

    Glycerol, [14C(U)]

    Glycerol, uniformly labeled with C-14. 14C-glycerol is commonly used to label carbohydrates.
    Price Range : 826.00 USD - 2812.00 USD
  • Albumin (mouse) AlphaLISA Detection Kit

    The AlphaLISA® Mouse Albumin Detection Kit is designed for the quantitative detection of mouse albumin in serum, urine, buffered solution or cell culture medium, using a homogeneous (no wash steps, no separation steps) assay.
    Price Range : 3036.00 USD - 23700.00 USD
  • AlphaLISA immunoassay kits

    Insulin (human) AlphaLISA Detection Kit

    The AlphaLISA® immunoassay kit for human insulin enables the detection and quantitation of insulin in serum, buffered solution or cell culture medium using a homogeneous AlphaLISA assay (no wash steps). The antibodies in the kit are mouse monoclonal antibodies (clone numbers 8E2 and 3A6).
    Price Range : 1585.00 USD - 10500.00 USD
  • Diclofenac sodium- Phenylacetic acid C14

    Glucose 1-Phosphate, α-D-[14C(U)]-, Dipotassium Salt, 50µCi (1.85MBq)

    50 µCi quantities of α-D-[14C(U)]-Glucose 1-Phosphate, Dipotassium Salt are available for your research.
    List Price : 1551.00 USD
  • LANCE Detection Kit

    Leptin (human) LANCE Ultra TR-FRET Detection Kit

    The LANCE® Ultra Human Leptin Detection Kit is designed for detection and quantitation of human leptin in cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.
    Price Range : 830.00 USD - 11000.00 USD
  • AlphaLISA immunoassay kits

    PON-2 (human) AlphaLISA Detection Kit

    The AlphaLISA® immunoassay kit for human PON-2 enables the quantitative determination of human Paraoxonase 2 (PON-2) in buffered solution, cell culture media, and cell lysates using a homogeneous AlphaLISA assay (no wash steps).
    Price Range : 759.00 USD - 14600.00 USD
  • Diclofenac sodium- Phenylacetic acid C14

    Citric Acid, [1,5-14C]

    Citric acid, labeled with C-14 at C1 and C5. 14C-citrate is commonly used to label long-chain fatty acids.
    Price Range : 980.00 USD - 3515.00 USD
  • GLP-1 (7-36) (human) LANCE Ultra TR-FRET Detection Kit

    The LANCE® Ultra Human GLP-1 (7-36) Detection Kit is designed for detection and quantitation of human GLP-1 (7-36) in cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.
    Price Range : 829.00 USD - 11100.00 USD
  • Diclofenac sodium- Phenylacetic acid C14

    Galactose 1-Phosphate, D-[14C(U)]

    D-galactose 1-phosphate, labeled uniformly with carbon-14. This product is typically used in galactose metabolism studies.
    Price Range : 1054.00 USD - 2727.00 USD
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Business Insights (3)
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1-3 of 3 Business Insights

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  • White Paper

    Streamlining Materials Innovation Processes with Electronic Lab Notebook (ELN) and Data Analytics for Optimum Efficiency

    This paper explores the numerous challenges materials scientists and engineers face, from the time it takes to bring new materials to market to the difficulties delivering suitable formulations and testing against specified criteria, and how those can be resolved.

  • Application Note

    MicroCT Investigation of Bone Erosion and Deformation in an Osteoarthritic Rat Model

    Osteoarthritis (OA) is the most common form of arthritis and affects a considerable portion of the elderly population. In the U.S., it is estimated that more than 630 million people worldwide have this chronic condition, generally in the knees. OA occurs when the cartilage that cushions the ends of bones within the joints gradually deteriorates, causing synovitis and joint deformation.

    The goal of OA research is to identify new therapeutic strategies that could prevent, reduce, halt progression, or repair the existing damage to the joint. Non-invasive in vivo imaging such as microCT is the standard modality for bone research due to its ability to obtain high-resolution images at an x-ray dose low enough as not to harm the animal. This makes microCT ideal for monitoring disease progression and response to treatments in the same animal over time. However, microCT data visualization and analysis can be cumbersome and time consuming. In this application note, we compared standard microCT software and advanced bone software to investigate bone erosion in an OA rat model.

  • Application Note

    Contrast-enhanced Imaging of Vasculature and Soft Tissues Using the Quantum GX MicroCT System

    X-ray CT imaging is commonly used for skeletal imaging as bones are densely mineralized tissues with excellent x-ray attenuation properties. In contrast, soft, less dense tissues often prove to be challenging to image due to their lack of sufficient tissue density. Soft tissues such as muscle, blood vessels and internal organs share similar x-ray attenuation characteristics and are not distinguishable under typical CT settings. In order to introduce density that would improve soft tissue contrast, several contrast agents have been developed for use in clinical and preclinical settings. This application note outlines the use of iodine and nanoparticle-based contrast agents for imaging soft tissues and vasculature in various organs using the Quantum GX to gain further insights into disease and therapeutic response.