Ligands

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Eliminate the need for antibodies and reduce assay time with direct detection using our radiolabeled ligands, which provide for sensitive and quantitative measurement of binding.

High specific activity — The majority of our 125I-labeled ligands are offered at maximum specific activity. This means virtually every molecule of ligand provided in the stock vial is radiolabeled. For tritiated ligands (3H ligands), pick a ligand with specific activity above 20 Ci/mmol – all of our tritiated ligands meets or exceeds these requirements.
High purity — We offer highly-pure radioligands for the highest specific signal with low background in binding assays.
High selectivity — Our broad portfolio of agonists and antagonists offers many options for choosing the most selective compound for your receptor.
Validated for receptor binding — all of our radioligand products are tested for receptor binding during development. Additionally, many of our radioligands are used to QC our GPCR and receptor cell lines and cell membrane products.

Products & Services (112)
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Products & Services (112)

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NEN Radiochemicals (109)

Detection Method

Radiometric (108)

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5-Hydroxytryptamine (13)
Acetylcholine (1)
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Vesicular Amine Transporters (VATs) (1)

Radioisotope

C-14 (6)
H-3 (104)
S-35 (1)

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¹⁴C (5)
³⁵S (1)
³H (2)
³H (103)

Label Position

Generally Labeled (6)
Nominally Labeled (23)
Specifically Labeled (82)
Uniformly Labeled (1)

Concentration

1 mCi/mL (3)
1.0 - 10 mCi/mL (55)
1.0 - 10 µCi/mL (1)
<1.0 mCi/mL (7)

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In vitro (1)

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0-50 (33)
201-250 (54)

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1-25 of 112 Products & Services

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SCH 23390, [N-Methyl-³H]

NET930025UC , NET930250UC , NET930001MC

SCH-23390 (halobenzazepine), tritiated on the N-methyl group. SCH-23390 acts as an antagonist at the dopamine D₁ receptor.

Price Range : 632.00 USD - 3454.00 USD
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Enkephalin, [Tyrosyl-2,6-³H(N)]- (2-D-Penicillamine, 5-D-Penicillamine) (DPDPE)

NET922050UC , NET922250UC

2-D-Penicillamine, 5-D-Penicillamine (DPDPE), tritiated on the tyrosyl group. Cyclic peptide, sequence: Tyr-D-Pen-Gly-Phe-D-Pen-OH. DPDPE is a synthetic enkephalin opioid peptide that acts as an agonist at delta opiate receptors (δ-opioid receptor, DOR).

Price Range : 1286.00 USD - 5700.00 USD
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Paroxetine, [Phenyl-6'-³H]

NET869025UC , NET869250UC

Paroxetine (Paxil), tritiated at the phenyl-6′ position. Paroxetine is a selective serotonin reuptake inhibitor (SSRI).

Price Range : 753.00 USD - 5400.00 USD
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Norepinephrine, Levo-[7-³H]

NET377250UC , NET377001MC , NET377005MC

Levo-Norepinephrine, tritiated at the 7 position. Norepinephrine binds and activates adrenergic receptors, and is cleared by the norepinehprine transporter (NET). This product has scheduled lot release dates for the third Monday in January and July.

Price Range : 1451.00 USD - 12100.00 USD
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Raclopride, [Methoxy-³H]

NET975025UC , NET975250UC , NET975001MC

Raclopride, [Methoxy-³H]-

Price Range : 678.00 USD - 5400.00 USD
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U-69,593, [Phenyl-3,4-³H]

NET952025UC , NET952250UC

U-69,593, tritiated at the phenyl-3,4 position. U-69,593 is a selective κ1-opioid receptor agonist.

Price Range : 839.00 USD - 2735.00 USD
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Nisoxetine Hydrochloride, [N-Methyl-³H]-, 250µCi (9.25MBq)

NET1084250UC

Nisoxetine hydrochloride, tritiated on the N-methyl group. Nisoxetine is a potent and selective inhibitor of the norepinephrine transporter.

List Price : 2740.00 USD
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Cocaine, Levo-[benzoyl-3,4-3H(N)]-

NET510250UC

Cocaine, tritiated at the benzoyl-3,4 position. Cocaine binds and blocks the dopamine transporter, preventing removal of dopamine from synapses in the brain.

List Price : 4306.00 USD
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CP 55940, [Side Chain-2,3,4-³H(N)]

NET1051025UC , NET1051250UC , NET1051001MC

CP 55,940, tritiated on the side chain-2,3-4 position. CP 55,940 is a synthetic cannabinoid that acts as a full agonist at both cannabinoid CB₁ and CB₂ receptors, and can also upregulate serotonin 5-HT_2A receptors.

Price Range : 812.00 USD - 6800.00 USD
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GR125743, [N-methyl-³H]

NET1172U100UC

GR125743, tritiated on the N-methyl group. GR125743 acts as an antagonist at serotonin 5-HT_1B and 5-HT_1D receptors. This product will have scheduled availability dates on the third Monday in February and August.

List Price : 2725.00 USD
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(+/-) Epibatidine, [5,6-Bicycloheptyl-³H]

NET1102025UC , NET1102250UC

(+/-)-Epibatidine radioligand tritiated at the 5,6-biocycloheptyl position. Epibatidine has analgesic activities, has been shown to function as an agonist at nicotinic acetylcholine receptors, and has been shown to bind muscarinic and serotonin 5-HT3 receptors.

Price Range : 2091.00 USD - 5500.00 USD
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SR 95531, [Butyryl-2,3-³H]-, 250µCi (9.25MBq)

NET946250UC

SR-95531 (Gabazine), tritiated at the butyryl-2,3 position. SR-95531 acts as an antagonist at GABA_A receptors.

List Price : 3799.00 USD
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Dihydroxyphenylethylamine, 3,4-[7-³H]

NET131250UC , NET131001MC

Dihydroxyphenylethylamine (dopamine, DA), tritiated at the 7 position. Dihydroxyphenylethylamine is a neurotransmitter and is the primary endogenous ligand for dopamine receptors. This product has a scheduled lot release for the second Monday in April and October.

Price Range : 1306.00 USD - 3957.00 USD
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Gabapentin [³H]

NET1182001MC

Tritiated gabapentin (Neurontin). Gabapentin is a medication used to treat epilepsy, and has been shown to cross membrane lipid barriers via system L-amino acid transporters and bind to voltage-gated calcium channels in the central nervous system. This product has a scheduled release for the third Monday in February and September.

List Price : 6500.00 USD
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RO 15-4513, [7,9-³H]-, 250µCi (9.25MBq)

NET925250UC

Ro15-4513, tritiated at the 7,9 position. Ro15-4513 is a partial inverse agonist at GABA_A receptors.

List Price : 2920.00 USD
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Bradykinin, [2,3-Prolyl-3,4-³H(N)]

NET706050UC , NET706250UC

Bradykinin, tritiated at the 2,3-prolyl-3,4 position. Bradykinin is the endogenous ligand that activates bradykinin B₁ and B₂ receptors.

Price Range : 2136.00 USD - 4876.00 USD
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Flunitrazepam, [Methyl-³H]

NET567250UC , NET567001MC

Flunitrazepam (Rohypnol), tritiated on the methyl group. Flunitrazepam is a benzodiazepine and acts as an agonist at GABA_A (γ-aminobutyric acid) receptors.

Price Range : 1973.00 USD - 6400.00 USD
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5-CT, [³H]

NET1188U100UC

5-carboxyamidotryptamine (5-CT) labeled with tritium. 5-CT is a tryptamine derivative closely related to the neurotransmitter serotonin. 5-CT acts as a non-selective, high-affinity full agonist at the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5A, and 5-HT7 serotonin receptors. It also binds the 5-HT2, 5-HT3, 5-HT6 serotonin receptors with lower affinity.

List Price : 1899.00 USD
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Substance-P (9-Sar, 11-Met(O₂)), [2-Prolyl-3,4-³H]-, 50µCi (1.85MBq)

NET1025050UC

Substance-P, tritiated on the 2-prolyl group. Substance-P acts as an antagonist at neurokinin-1 receptors (NK1Rs).

List Price : 3741.00 USD
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Pirenzepine, [N-Methyl-³H]

NET780250UC , NET780001MC

Pirenzepine, tritiated on the N-methyl group. Pirenzepine acts as a selective antagonist of the muscarinic M₁ acetylcholine receptor.

Price Range : 2355.00 USD - 6000.00 USD
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CGS 21680, [Carboxyethyl-³H(N)]

NET1021250UC , NET1021001MC

CGS 21680, tritiated at the carboxyethyl group. CGS 21680 acts as an agonist for the adenosine A_2A receptor, but can also bind adenosine A₁ and A₃.

Price Range : 2223.00 USD - 5400.00 USD
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8-Hydroxy-DPAT, [Propyl-2,3-ring-1,2,3-³H]-

NET929250UC , NET929001MC

8-OH-DPAT radioligand tritiated at the 1,2,3 position on the propyl-2,3-ring. 8-OH-DPAT is a serotonin receptor agonist specific for the 5-HT_1A and 5-HT₇ receptors.

Price Range : 1457.00 USD - 4033.00 USD
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(+)-Pentazocine, [Ring-1,3-³H]

NET1056025UC , NET1056250UC , NET1056001MC

(+)-Pentazocine radioligand tritiated at the 1,3 position on the ring. Pentazocine is a synthetic opioid shown to bind sigma 1 receptor.

Price Range : 754.00 USD - 5900.00 USD
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Cyclopentyl-1,3-Dipropylxanthine, 8-[Dipropyl-2,3-³H(N)]

NET974250UC , NET974001MC

8-Cyclopentyl-1,3-dipropylxanthine (DPCPX, PD-116,948), tritiated at the dipropyl-2,3- positions. DPCPX acts as a potent and selective antagonist for the adenosine A₁ receptor.

Price Range : 1579.00 USD - 3618.00 USD
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Iodoantipyrine, 4-[N-Methyl-¹⁴C]

NEC712050UC , NEC712250UC , NEC712001MC

4-Iodoantipyrine, labeled with C-14 on the N-methyl group. Iodoantipyrine has been used to measure cerebral blood flow.

Price Range : 856.00 USD - 7000.00 USD

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