PerkinElmer

Lead Optimization

OF

Engineer drug candidates with the lowest risk of failure in the critical latter stages of drug development. Our lead optimization solutions reduce off-target activity through improved selectivity, enhance potency, and improve the chemical and metabolic properties of the lead compound for better in vivo pharmacodynamics and pharmacokinetics. We also offer informatics software applications that help you manage chemical structures and their associated data and properties in an efficient and chemically intelligent way.

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1-25 of 121 Products & Services

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  • EnSight Multimode Plate Reader

    EnSight Multimode Plate Reader

    The EnSight multimode plate reader offers HTS Alpha, Ultra-sensitive Luminescence and fast well-imaging technologies alongside conventional multimode detection technologies. Imaging & online data analysis is fast: a 384-well plate can be imaged in less than 5 mins. The system’s modular design, combined with workflow-based Kaleido data acquisition & analysis software, gives a truly versatile plate reader that gets users productive quickly.
  • G8 PET/CT benchtop scanner for preclinical imaging research

    G8 PET/CT Preclinical Imaging System

    Ultrasensitive and fast multimodal preclinical PET/CT imaging at your benchtop. The G-Platform offers Full Solutions for PET Imaging  and includes the G4 and G8 imaging systems.
  • 1000x1000_Opera_Phenix

    Opera Phenix High-Content Screening System

    The Opera Phenix High Content Screening System is the premier confocal solution for today's most demanding high content applications. Drawing on over a decade of experience with the industry-leading Opera® High Content Screening System, the Opera Phenix is designed for high-throughput, phenotypic screening and assays involving complex disease models, such as live cells, primary cells and microtissues.
  • Spectrum-CU-Hero

    IVIS Spectrum In Vivo Imaging System

    The IVIS® Spectrum in vivo imaging system combines 2D optical and 3D optical tomography in one platform. The system uses leading optical technology for preclinical imaging research and development ideal for non-invasive longitudinal monitoring of disease progression, cell trafficking and gene expression patterns in living animals.
  • EnVision 2105 multimode plate reader

    EnVision 2105 Multimode Plate Reader

    The EnVision® 2105 multimode plate reader provides exceptional speed, ultra-high throughput, and maximum sensitivity across all detection technologies. Tried and tested, the EnVision microplate reader gives you robust performance and reliable data for high throughput screening, time after time.

    The EnVision 2105 model delivers even higher sensitivity for time-resolved fluorescence (TRF) applications, and the Enhanced Security software option includes tools to facilitate 21 CFR Part 11 compliance for integration into regulated environments (GxP). In addition, the Alpha 775 laser module is designed for plant assays.

  • IVIS-SpectrumCT-Hero

    IVIS SpectrumCT In Vivo Imaging System

    The IVIS® SpectumCT preclinical in vivo imaging system expands upon the versatility of the IVIS Spectrum by offering 2D and 3D imaging capabilities but includes integrated low-dose microCT ideal for longitudinal studies. The system provides researchers with greater insights into complex biological systems by enabling simultaneous molecular and anatomical non-invasive imaging in animal models.
  • SpectrumBL-CU-Hero

    IVIS SpectrumBL High-Throughput In Vivo Optical Imaging System

    The IVIS® SpectrumBL is an advanced high-throughput 2D and 3D optical imaging system designed to improve quantitative outcomes of bioluminescent, chemiluminescent and Cerenkov in vivo imaging.
  • FMT In Vivo Imaging Instrument

    FMT 4000 In Vivo Imaging System

    The FMT 4000 fluorescence tomography imaging system provides the greatest utility of the FMT Systems with the ability to quantitate up to four fluorophores simultaneously. It comes with four excitation laser channels (635, 680, 750, & 790 nm).
  • FMT In Vivo Imaging Instrument

    FMT 1000 In Vivo Imaging System

    The FMT® 1000 is an entry level 3D fluorescence tomographic system with the ability to quantitate a single fluorophore at a time.
  • FMT In Vivo Imaging Instrument

    FMT 2000 In Vivo Imaging System

    The FMT 2000 is a workhorse 3D fluorescence tomographic system with the ability to quantitate up to two fluorophores simultaneously.
  • VictorX_ImageA_320px

    VICTOR Multilabel Plate Reader

    The VICTOR Multilabel plate reader has been replaced by the VICTOR Nivo multimode plate reader. Please contact your local representative for further information, or visit the VICTOR Nivo product page (Part Number - HH35000500).
  • 1000x1000_Operetta

    Operetta CLS High-Content Analysis System

    Uncover deep biological understanding in your everyday assays and innovative applications using the Operetta CLS high-content analysis system. Featuring a unique combination of technologies, the system delivers all the speed, sensitivity and resolution you need to reveal fine sub-cellular details. And with our simple, powerful Harmony 4.5 software, Operetta CLS lets you find even subtle phenotypic changes.
  • IVIS Lumina HT High Throughput Benchtop 2D Optical Imaging System

    IVIS Lumina III In Vivo Imaging System

    The IVIS® Lumina Series III brings together years of leading optical imaging technologies into one easy to use and exquisitely sensitive bench-top system.
  • IVIS Lumina XRMS 2D Optical Imaging System with Integrated X-ray

    IVIS Lumina XRMS In Vivo Imaging System

    Industry leading Fluorescence, Bioluminescence and X-Ray Imaging - All-In-One benchtop instrument! The IVIS® Lumina XRMS (x-ray multi-species optical imaging system) adds to the versatility of the IVIS Lumina XR by offering the flexibility to image large animals up to 500 grams with precise optical and X-Ray overlay.
  • IVIS Lumina HT High Throughput Benchtop 2D Optical Imaging System

    IVIS Lumina LT In Vivo Imaging System

    The IVIS® Lumina LT Series III pre-clinical in vivo imaging system offers the industries most sensitive benchtop platform at an entry level price.
  • PerkinElmer

    ProfilerPro Kinase Peptide Substrate 16, for LabChip EZ Reader

    Fluorescently-labelled peptide substrate 16 for kinase assays (inhibiton, target discovery, lead optimization)
    List Price : 757.00 USD
  • PerkinElmer

    ProfilerPro Kinase Peptide Substrate 19, for LabChip EZ Reader

    Fluorescently-labelled peptide substrate 19 for kinase assays (inhibiton, target discovery, lead optimization)
    List Price : 757.00 USD
  • PerkinElmer

    ProfilerPro Kinase Peptide Substrate 18, for LabChip EZ Reader

    Fluorescently-labelled peptide substrate 18 for kinase assays (inhibiton, target discovery, lead optimization)
    List Price : 757.00 USD
  • PerkinElmer

    ProfilerPro Kinase Peptide Substrate 24, for LabChip EZ Reader

    Fluorescently-labelled peptide substrate 24 for kinase assays (inhibiton, target discovery, lead optimization)
    List Price : 757.00 USD
  • PerkinElmer

    ProfilerPro Kinase Peptide Substrate 20, for LabChip EZ Reader

    Fluorescently-labelled peptide substrate 20 for kinase assays (inhibiton, target discovery, lead optimization)
    List Price : 757.00 USD
  • PerkinElmer

    ProfilerPro Kinase Peptide Substrate 26, for LabChip EZ Reader

    Fluorescently-labelled peptide substrate 26 for kinase assays (inhibiton, target discovery, lead optimization)
    List Price : 757.00 USD
  • PerkinElmer

    ProfilerPro Kinase Selectivity Assay Plate Kit 3, for LabChip EZ Reader

    Kit consist of matched pairs of 384-well kinase-assay and substrate plates. Each assay plate contains 24 different predispensed frozen kinases. Substrate plates contain the appropriate fluorescent labeled peptides and ATP.
    List Price : 1637.00 USD
  • PerkinElmer

    ProfilerPro Kinase Peptide Substrate 27, for LabChip EZ Reader

    Fluorescently-labelled peptide substrate 27 for kinase assays (inhibiton, target discovery, lead optimization)
    List Price : 757.00 USD
  • PerkinElmer

    LabChip ProfilerPro Separation Buffer (400 ml) including Coating Reagent 8, for EZ Reader

    Separation buffer containing coating reagent 8 (CR8), a positively-charged additive that binds the silanol groups of the glass channels in the LabChip multi-sipper chip (the glass is negatively-charged) to neutralize the charge. Non-specific interaction of substrates and products that are highly positively charged, or substrates with sequences containing repeats of a positive charge, will be reduced with this separation buffer.
    List Price : 216.00 USD
  • PerkinElmer

    PDE Substrate iFL-cGMP, for LabChip EZ Reader

    Fluorescently-labelled cGMP for Phosphodiesterase Assays (Enyzme inhibiton, target discovery, lead optimization)
    List Price : 757.00 USD
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