PerkinElmer

Lead Optimization

OF

Engineer drug candidates with the lowest risk of failure in the critical latter stages of drug development. Our lead optimization solutions reduce off-target activity through improved selectivity, enhance potency, and improve the chemical and metabolic properties of the lead compound for better in vivo pharmacodynamics and pharmacokinetics. We also offer informatics software applications that help you manage chemical structures and their associated data and properties in an efficient and chemically intelligent way.

Products & Services (137)
Filters:
Product Type
  • Accessories (43)
  • Consumables (4)
  • Instruments (10)
  • Reagents (75)
  • Software and Informatics (5)
Target Species
  • Mouse (6)
  • Rabbit (6)
Application
  • Flow Cytometry (25)
  • High Content Screening (27)
  • Imaging Microscopy (25)
  • Mobility Shift (36)
Therapeutic Area
  • Cardiovascular Diseases (8)
  • Fibrosis (3)
  • Metabolic Disorders (5)
  • Neurology (7)
  • Oncology (7)
Product Brand Name
  • EnSight (1)
  • EnVision (1)
  • IVIS (6)
  • LabChip EZ Reader (49)
  • Operetta (28)
  • Operetta CLS (9)
  • Operetta CLS AND Opera Phenix (9)
  • PhenoVue (27)
  • Victor (1)
Detection Method
  • Absorbance (3)
  • Alpha (2)
  • Fluorescence (31)
  • Fluorescence Polarization (2)
  • Image-based Cytometry (1)
  • Luminescence (3)
  • Time-Resolved Fluorescence (TRF) (3)
  • Transmission (1)
Sample Type
  • Enzyme (38)
Fluorophore
  • PhenoVue Fluor 488 (4)
  • PhenoVue Fluor 568 (4)
  • PhenoVue Fluor 594 (4)
  • PhenoVue Fluor 488 (1)
  • PhenoVue Fluor 568 (1)
  • PhenoVue Fluor 594 (1)
Automation Compatible
  • Yes (30)
Format
  • Dessicated (6)
  • Liquid (3)
  • Lyophilized (15)
  • Powder (1)
Imaging Modality
  • High Content (1)
  • microCT Imaging (1)
  • Optical Imaging (6)
Model Compatible With
  • Opera Phenix Plus (1)
  • Operetta (29)
  • Operetta CLS (8)
  • Operetta CLS AND Opera Phenix (10)

Sort by

1-25 of 137 Products & Services

  • IVIS Lumina XRMS 2D Optical Imaging System with Integrated X-ray

    IVIS Lumina XRMS In Vivo Imaging System

    Industry leading Fluorescence, Bioluminescence and X-Ray Imaging - All-In-One benchtop instrument! The IVIS® Lumina XRMS (x-ray multi-species optical imaging system) adds to the versatility of the IVIS Lumina XR by offering the flexibility to image large animals up to 500 grams with precise optical and X-Ray overlay.
  • EnVision 2105 multimode plate reader

    EnVision Multimode Plate Reader

    The EnVision® 2105 multimode plate reader provides exceptional speed, ultra-high throughput, and maximum sensitivity across all detection technologies. Tried and tested, the EnVision microplate reader gives you robust performance and reliable data for high throughput screening, time after time.

    The EnVision 2105 model delivers even higher sensitivity for time-resolved fluorescence (TRF) applications, and the Enhanced Security software option includes tools to facilitate 21 CFR Part 11 compliance for integration into regulated environments (GxP).

  • IVIS Lumina HT High Throughput Benchtop 2D Optical Imaging System

    IVIS® Lumina LT In Vivo Imaging System

    The IVIS® Lumina LT Series III pre-clinical in vivo imaging system offers the industries most sensitive benchtop platform at an entry level price.
  • SpectrumBL-CU-Hero

    IVIS® SpectrumBL High-Throughput In Vivo Optical Imaging System

    The IVIS® SpectrumBL is an advanced high-throughput 2D and 3D optical imaging system designed to improve quantitative outcomes of bioluminescent, chemiluminescent and Cerenkov in vivo imaging.
  • IVIS Lumina HT High Throughput Benchtop 2D Optical Imaging System

    IVIS® Lumina III In Vivo Imaging System

    The IVIS® Lumina Series III brings together years of leading optical imaging technologies into one easy to use and exquisitely sensitive bench-top system.
  • Operetta CLS High-Content Analysis System

    Operetta CLS High-Content Analysis System

    Uncover deep biological understanding in your everyday assays and innovative applications using the Operetta CLS high-content analysis system. Featuring a unique combination of technologies, the system delivers all the speed, sensitivity and resolution you need to reveal fine sub-cellular details. And with our simple, powerful Harmony 4.5 software, Operetta CLS lets you find even subtle phenotypic changes.
  • EnSight Multimode Plate Reader

    EnSight Multimode Plate Reader

    The EnSight multimode plate reader offers HTS Alpha, Ultra-sensitive Luminescence and fast well-imaging technologies alongside conventional multimode detection technologies. Imaging & online data analysis is fast: a 384-well plate can be imaged in less than 5 mins. The system’s modular design, combined with workflow-based Kaleido data acquisition & analysis software, gives a truly versatile plate reader that gets users productive quickly.
  • IVIS-SpectrumCT-Hero

    IVIS® SpectrumCT In Vivo Imaging System

    The IVIS® SpectrumCT preclinical in vivo imaging system expands upon the versatility of the IVIS Spectrum by offering 2D and 3D imaging capabilities but includes integrated low-dose microCT ideal for longitudinal studies. The system provides researchers with greater insights into complex biological systems by enabling simultaneous molecular and anatomical non-invasive imaging in animal models.
  • VictorX_ImageA_320px

    VICTOR Multilabel Plate Reader

    The VICTOR Multilabel plate reader has been replaced by the VICTOR Nivo multimode plate reader. Please contact your local representative for further information, or visit the VICTOR Nivo product page (Part Number - HH35000500).
  • Spectrum-CU-Hero

    IVIS Spectrum In Vivo Imaging System

    The IVIS® Spectrum in vivo imaging system combines 2D optical and 3D optical tomography in one platform. The system uses leading optical technology for preclinical imaging research and development ideal for non-invasive longitudinal monitoring of disease progression, cell trafficking and gene expression patterns in living animals.
  • PhenoVue Fluor 594 - Goat Anti-Mouse Antibody Cross-Adsorbed

    PhenoVue Fluor 594 - Goat Anti-Mouse Antibody Cross-Adsorbed

    Cross-adsorbed goat anti-mouse IgG (H+L) antibody conjugated with PhenoVue Fluor 594.

    PhenoVue Fluor 594 secondary antibody conjugates exhbibit bright red fluorescence and are validated for use in high-content screening applications.

    Part of PerkinElmer’s portfolio of cellular imaging reagents, the PhenoVue Fluor - 594 goat anti-mouse antibody, cross-adsorbed, has a maximum excitation wavelength of 590nm and a maximum emission wavelength of 617nm.

    List Price : 175.00 USD
  • PerkinElmer

    LabChip Sipper Chip Coating Reagent 3 (35 ml), for EZ Reader

    CR-3, or Coating Reagent 3, is an essential component in separation buffer that coats the inner channels of a microfluidic chip to prevent the adsorption and build-up of substrate peptides and other assay components. CR-3 is already present in ProfilerPro Separation Buffer (#760367) at a concentration of 0.1% and does NOT need to be added to Separation Buffer unless you are making your own formulation.
    List Price : 241.00 USD
  • PhenoVue Dye Diluent A (5X)

    PhenoVue Dye Diluent A (5X)

    PhenoVue Dye Diluent A (5X) is an optimized buffer that can be used to dilute PhenoVue fluorescent products.

    List Price : 40.00 USD
  • PerkinElmer

    ProfilerPro Kinase Selectivity Assay Plate Kit 5, for LabChip EZ Reader

    Kit consist of matched pairs of 384-well kinase-assay and substrate plates. Each assay plate contains 24 different predispensed frozen kinases. Substrate plates contain the appropriate fluorescent labeled peptides and ATP.
    List Price : 1685.00 USD
  • PhenoVue Hoechst 33342 Nuclear Stain

    PhenoVue Hoechst 33342 Nuclear Stain

     

    PhenoVue Hoechst 33342 nuclear stain is a cell-permeable organic molecule that binds to DNA.

    PhenoVue Hoechst 33342 nuclear stain exhibits bright blue fluorescence and is validated for use in imaging microscopy and high-content screening applications.

    Part of PerkinElmer's portfolio of cellular imaging reagents, the PhenoVue Hoechst 33342 nuclear stain has a maximum excitation wavelength of 357 nm and a maximum emission wavelength of 540 nm.

    Price Range : 50.00 USD - 97.00 USD
  • PhenoVue 641 Mitochondrial Stain

    PhenoVue 641 Mitochondrial Stain

    PhenoVue 641 Mitochondrial stain is a fluorescent dye which accumulates in heathly mitochondria of live cells.

    PhenoVue 641 Mitochondria stain exhibits bright red fluorescence and is validated for use in imaging microscopy and high-content screening applications.

    Part of PerkinElmer's portfolio of cellular imaging reagents, PhenoVue 578 Mitochondrial stain has a maximum excitation wavelength of 641 nm and a maximum emission wavelength of 662 nm, which makes it an alternative to the similar MitoTracker Deep Red FM.

    List Price : 340.00 USD
  • PhenoVue Fluor 488 - WGA

    PhenoVue Fluor 488 - WGA

    PhenoVue Fluor 488 - WGA is a fluorescent lectin which displays high affinity for sialic acid and N-acetylglucosamine residues of glycoproteins and glycolipids present at the cellular plasma membranes. It can be used for cellular membrane staining, particularly the Golgi apparatus.

    PhenoVue Fluor 488 - WGA exhibits bright green fluorescence and is validated for use in imaging microscopy and high-content screening applications.

    Part of PerkinElmer's portfolio of cellular imaging reagents, PhenoVue Fluor 488 - WGA has a maximum excitation wavelength of 495 nm and a maximum emission wavelength of 520 nm.

    List Price : 320.00 USD
  • PerkinElmer

    ProfilerPro Kinase Selectivity Assay Plate Kit 6, for LabChip EZ Reader

    Kit consist of matched pairs of 384-well kinase-assay and substrate plates. Each assay plate contains 24 different predispensed frozen kinases. Substrate plates contain the appropriate fluorescent labeled peptides and ATP.
    List Price : 1686.00 USD
  • PerkinElmer

    HDAC (Histone Deacylase) Substrate A, for LabChip EZ Reader

    Fluorescently-labelled Substrate A peptide (Acetylated) for Epigenetic Assays (Enzyme inhibiton, target discovery, lead optimization)
    List Price : 780.00 USD
  • PerkinElmer

    ProfilerPro Kinase Peptide Substrate 10, for LabChip EZ Reader

    Fluorescently-labelled peptide substrate 10 for kinase assays (inhibiton, target discovery, lead optimization)
    List Price : 779.00 USD
  • PerkinElmer

    PDE Substrate iFL-cAMP, for LabChip EZ Reader

    Fluorescently-labelled cAMP for Phosphodiesterase Assays (Enyzme inhibiton, target discovery, lead optimization)
    List Price : 780.00 USD
  • PhenoVue 551 Mitochondrial Stain

    PhenoVue 551 Mitochondrial Stain

    PhenoVue 551 Mitochondrial stain is a fluorescent dye which accumulates in heathly mitochondria of live cells.

    PhenoVue 551 Mitochondrial stain exhibits bright orange fluorescence and is validated for use in imaging microscopy and high-content screening applications.

    Part of PerkinElmer's portfolio of cellular imaging reagents, PhenoVue 551 Mitochondrial stain has a maximum excitation wavelength of 551 nm and a maximum emission wavelength of 576 nm, which makes it an alternative to the similar stain MitoTracker Orange CMTMRos.

    List Price : 340.00 USD
  • PhenoVue Fluor 594 - WGA

    PhenoVue Fluor 594 - WGA

    PhenoVue Fluor 594 - WGA is a fluorescent lectin which displays high affinity for sialic acid and N-acetylglucosamine residues of glycoproteins and glycolipids present at the cellular plasma membranes. It can be used for cellular membrane staining, particularly the Golgi apparatus.

    PhenoVue Fluor 594 - WGA exhibits bright green fluorescence and is validated for use in imaging microscopy and high-content screening applications.

    Part of PerkinElmer's portfolio of cellular imaging reagents, PhenoVue Fluor 594 - WGA has a maximum excitation wavelength of 590 nm and a maximum emission wavelength of 617 nm.

    List Price : 320.00 USD
  • PerkinElmer

    ProfilerPro Kinase Peptide Substrate 7, for LabChip EZ Reader

    Fluorescently-labelled peptide substrate 7 for kinase assays (inhibiton, target discovery, lead optimization)
    List Price : 780.00 USD
  • PerkinElmer

    ProfilerPro Kinase Peptide Substrate 5, for LabChip EZ Reader

    Fluorescently-labelled peptide substrate 5 for kinase assays (inhibiton, target discovery, lead optimization)
    List Price : 780.00 USD
  • Jump to:
Resource Library (319)
Filters:
Resource Library
  • Application Note (13)
  • Article (4)
  • Brochure (1)
  • Case Study (3)
  • Ebook (3)
  • Poster (3)
  • Technical Note (7)
  • White Paper (4)
Events

Sort by

1-25 of 38 Resource Library

  • Jump to: