Inflammation Research

The LANCE® Ultra™ Mouse/Rat IL-17A Detection Kit is designed for detection and quantitation of mouse or rat interleukin-17A in cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.

This is a replacement for TRF1514.

Measure binding of small molecule drug candidates to target protein in a cellular environment with Alpha SureFire^® CETSA^® target engagement assays. For use in combination with Pelago Bioscience's CETSA^® (Cellular Thermal Shift Assay) technology, this kit provides a convenient no-wash assay for detection and quantitation of small molecule binding to STING, and can be used in hit identification, hit confirmation, and lead optimization studies for increased confidence and better prediction early in the drug discovery process. Please note that a valid CETSA^® subscription from Pelago Biosciences is required for use.

In vivo optical imaging of vascular changes and vascular leak is an emerging modality for studying altered physiology in a variety of different cancers and inflammatory states. In oncology, increases in tumor vascular permeability can be an early indicator of tumor angiogenesis. In inflammatory disease increased vascular permeability can indicate alterations in fluid homeostasis in an acute edema response or in chronic organ conditions.

PerkinElmer’s AngioSense® NIR fluorescent probes are designed to evaluate vascular changes to better understand various disease states or provide valuable information on effects of drug candidates earlier in the development process.