PerkinElmer

Inflammation Research

OF

Inflammation is a natural marker for bodily health, and abnormal inflammatory response is indicated in an increasingly wide net of diseases and disorders, from cardiovascular disease and diabetes to major depression. Detect and quantitate inflammatory biomarkers with our wide range of in vivo, cellular, in situ, and biochemical inflammation research products.

Our products for inflammation research include:

  • LANCE® TR-FRET technology for detection and quantitation of cytokines and other biomarkers
  • AlphaLISA® Immunoassay kits for detection and quantitation of cytokines and other biomarkers
  • DELFIA® (dissociation-enhanced lanthanide fluorescence immunoassay) TRF technology
  • Cellular, tissue, and in vivo imaging systems
  • Near-infrared (NIR) fluorescent and chemiluminescent in vivo imaging agents
  • Target-specific radiolabeled ligands and receptor-transfected cell lines and membranes
  • High content screening

This product portfolio meets the demands of many types of inflammation research:

  • Quick and specific detection of inflammatory biomarkers in human and animal samples, including pro-inflammatory cytokines and chemokines like IL-8, IL-6, IL-2, IFN gamma, and TNF alpha and beta.
  • Monitoring acute and pulmonary inflammation and therapeutic treatment in animal models in real time
  • Phenotypic analysis
  • Targeted studies in various sample types with high sensitivity and specificity

Products & Services (326)
Filters:
Product Type
  • Accessories (43)
  • Consumables (2)
  • Instruments (8)
  • Reagents (268)
  • Software and Informatics (5)
Assay Target
  • CCL1 (1)
  • CCL18 (1)
  • CCL2 (3)
  • CCL3 (3)
  • CCL4 (1)
  • CCL5 (3)
  • CCL8 (1)
  • CRP (1)
  • CXCL1 (2)
  • CXCL1/GROα (2)
  • CXCL10 (3)
  • CXCL13 (4)
  • CXCL4/PF4 (2)
  • CXCL9 (3)
  • Cyr61 (1)
  • ERK1/2 (1)
  • Fibrinogen (2)
  • G-CSF (1)
  • GM-CSF (1)
  • HO-1 (2)
  • HO-2 (2)
  • HVEM (2)
  • IFN-λ2 (4)
  • IFNα (2)
  • IFNγ (10)
  • IKKα (1)
  • IL-18 (1)
  • IL-1RA (4)
  • IL-23 (2)
  • IL-23A (2)
  • IL-3 (2)
  • IL-31 (2)
  • IL-6 (3)
  • IL-7A (2)
  • IL10 (2)
  • IL11 (2)
  • IL12 (7)
  • IL12/p70 (1)
  • IL13 (3)
  • IL15 (1)
  • IL17A (5)
  • IL17F (4)
  • IL18BP (2)
  • IL1α (4)
  • IL1β (7)
  • IL2 (3)
  • IL21 (2)
  • IL22 (1)
  • IL23 (1)
  • IL25 (3)
  • IL28B (4)
  • IL31 (1)
  • IL33 (4)
  • IL4 (6)
  • IL5 (4)
  • IL6 (7)
  • IL7 (1)
  • IL8 (3)
  • INFβ (1)
  • IP10 (2)
  • IRAK4 (1)
  • IRAK4       (1)
  • JAK2 (1)
  • JNK1/2 (1)
  • MCP2 (1)
  • MIP1α (2)
  • MLKL (6)
  • Osteoprotegerin (3)
  • PDGF (2)
  • Periostin (1)
  • PLC G2 (5)
  • Rb (1)
  • RB (2)
  • Ribosmal Protein S6 (1)
  • Ribosomal Protein S6 (2)
  • RIPK1 (1)
  • RIPK1         (1)
  • S6 Ribosomal Protein (1)
  • SLP76 (2)
  • STAT1 (3)
  • STAT4 (1)
  • STAT6 (1)
  • STING (1)
  • TBK1 (2)
  • TNFα (12)
  • TNRFR1 (1)
  • TNRFR3 (1)
  • TREM2 (1)
  • TSLP (2)
Application
  • cAMP (10)
  • Drug Discovery & Development (12)
  • High biotin samples (6)
  • In vivo imaging (1)
  • Protein Analysis & Detection (166)
  • Protein Detection (26)
  • Protein-protein interactions (2)
  • Target Engagement (1)
Therapeutic Area
  • Angiogenesis (13)
  • Arthritis (9)
  • Atherosclerosis (6)
  • Auto-Immunity (2)
  • Autoimmunity (10)
  • Cancer (2)
  • Cardiovascular (9)
  • Central Nervous System (3)
  • CNS (5)
  • Gastrointestinal (4)
  • Immuno-oncology (2)
  • Inflammation (234)
  • Metabolic (4)
  • Metabolism (4)
  • Neuroinflammation (9)
  • Oncology (22)
  • Oncology/Cancer (9)
  • Pain (8)
  • Vascular disease (4)
Product Brand Name
  • AequoScreen (11)
  • AequoZen (8)
  • Alpha SureFire CETSA (1)
  • Alpha SureFire Multiplex (5)
  • Alpha SureFire Ultra Multiplex (2)
  • AlphaLISA (126)
  • AlphaLISA SureFire Ultra (26)
  • AlphaPlex (4)
  • cAMPZen (8)
  • Cat B FAST (2)
  • FMT (1)
  • FolateRSense (1)
  • IVIS (6)
  • LANCE Ultra (43)
  • Membrane Target Systems (8)
  • MMPSense (1)
  • Operetta (28)
  • Operetta CLS (9)
  • Operetta CLS AND Opera Phenix (9)
  • ProSense (1)
  • RediJect (2)
  • Superhance (1)
  • ValiScreen (10)
  • VivoTrack (1)
Detection Method
  • Alpha (165)
  • Fluorescence (1)
  • Time-Resolved Fluorescence (TRF) (25)
  • TR-FRET (25)
  • Transmission (1)
Receptor Type
  • Anaphylatoxin (1)
  • Bradykinin (4)
  • Chemokine (28)
  • Histamine (10)
  • Prostanoid (2)
Assay Validated
  • Binding (23)
  • Calcium Fluorescence (7)
  • Calcium Luminescence (19)
  • cAMP (16)
  • Downstream Phosphorylation (7)
  • GTPγS (9)
  • Inositol Phosphate (2)
Fluorescent Agent Type
  • Activatable (5)
  • Targeted (1)
  • Vascular (4)
Assay Points (200-50,000)
  • 0 (1)
  • 100 (83)
  • 10000 (57)
  • 500 (147)
  • 5000 (89)
  • 50000 (30)
Assay Target Class
  • Cytokine (148)
  • GPCR (45)
  • Phospho-protein (9)
  • Phosphoprotein (9)
  • Protein (41)
Automation Compatible
  • Yes (210)
Experimental Type
  • In vitro (161)
Format
  • Microplates (142)
Host Cell
  • CHO-K1 (43)
  • HEK293 (2)
Imaging Modality
  • Chemilumiluminescence (2)
  • Fluorescence (1)
  • High Content (1)
  • microCT Imaging (1)
  • Optical Imaging (7)
Length
  • 51-100 (1)
Model Compatible With
  • Opera Phenix Plus (1)
  • Operetta (29)
  • Operetta CLS (8)
  • Operetta CLS AND Opera Phenix (10)
Type
  • Explorer Kit (1)
  • Standard Kit (1)

Sort by

1-25 of 326 Products & Services

  • FMT In Vivo Imaging Instrument

    FMT 1000 In Vivo Imaging System

    The FMT® 1000 is an entry level 3D fluorescence tomographic system with the ability to quantitate a single fluorophore at a time.
  • IVIS Lumina HT High Throughput Benchtop 2D Optical Imaging System

    IVIS® Lumina III In Vivo Imaging System

    The IVIS® Lumina Series III brings together years of leading optical imaging technologies into one easy to use and exquisitely sensitive bench-top system.
  • IVIS-SpectrumCT-Hero

    IVIS® SpectrumCT In Vivo Imaging System

    The IVIS® SpectrumCT preclinical in vivo imaging system expands upon the versatility of the IVIS Spectrum by offering 2D and 3D imaging capabilities but includes integrated low-dose microCT ideal for longitudinal studies. The system provides researchers with greater insights into complex biological systems by enabling simultaneous molecular and anatomical non-invasive imaging in animal models.
  • Operetta CLS High-Content Analysis System

    Operetta CLS High-Content Analysis System

    Uncover deep biological understanding in your everyday assays and innovative applications using the Operetta CLS high-content analysis system. Featuring a unique combination of technologies, the system delivers all the speed, sensitivity and resolution you need to reveal fine sub-cellular details. And with our simple, powerful Harmony 4.5 software, Operetta CLS lets you find even subtle phenotypic changes.
  • Spectrum-CU-Hero

    IVIS Spectrum In Vivo Imaging System

    The IVIS® Spectrum in vivo imaging system combines 2D optical and 3D optical tomography in one platform. The system uses leading optical technology for preclinical imaging research and development ideal for non-invasive longitudinal monitoring of disease progression, cell trafficking and gene expression patterns in living animals.
  • IVIS Lumina XRMS 2D Optical Imaging System with Integrated X-ray

    IVIS Lumina XRMS In Vivo Imaging System

    Industry leading Fluorescence, Bioluminescence and X-Ray Imaging - All-In-One benchtop instrument! The IVIS® Lumina XRMS (x-ray multi-species optical imaging system) adds to the versatility of the IVIS Lumina XR by offering the flexibility to image large animals up to 500 grams with precise optical and X-Ray overlay.
  • IVIS Lumina HT High Throughput Benchtop 2D Optical Imaging System

    IVIS® Lumina LT In Vivo Imaging System

    The IVIS® Lumina LT Series III pre-clinical in vivo imaging system offers the industries most sensitive benchtop platform at an entry level price.
  • SpectrumBL-CU-Hero

    IVIS® SpectrumBL High-Throughput In Vivo Optical Imaging System

    The IVIS® SpectrumBL is an advanced high-throughput 2D and 3D optical imaging system designed to improve quantitative outcomes of bioluminescent, chemiluminescent and Cerenkov in vivo imaging.
  • CCL4/MIP-1ß (human) AlphaLISA Detection Kit

    The AlphaLISA® Human C-C Motif Chemokine 4 / Macrophage Inflammatory Protein-1beta (CCL4 / MIP-1ß) Detection Kit is designed for detection and quantitation of human CCL4/MIP-1ß in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.
    Price Range : 2035.00 USD - 12600.00 USD
  • IL-8 (human) AlphaLISA Detection Kit

    The AlphaLISA Human IL8 Detection Kit is designed for the quantitative determination of human IL-8 in serum, buffered solution or cell culture medium using a homogeneous (no wash steps, no separation steps) assay.
    Price Range : 1905.00 USD - 12600.00 USD
  • Phospho-TBK1 (Ser172) AlphaLISA SureFire Ultra Detection Kit

    The AlphaLISA® SureFire® Ultra™ p-TBK1 (Ser172) assay is a sandwich immunoassay for quantitative detection of phospho-TBK1 (phosphorylated on Ser172) in cellular lysates using Alpha Technology.

    Price Range : 553.00 USD - 36700.00 USD
  • IL-17F (human) AlphaLISA Detection Kit

    The AlphaLISA® Human IL-17F Detection Kit is designed for detection and quantitation of human interleukin 17F in cell culture media or serum using a homogeneous (no-wash steps, no separation steps) assay.
    Price Range : 774.00 USD - 23300.00 USD
  • AlphaLISA Sandwich Anti-AnalyteConjugatedAcceptorBead

    IL-6 (human) AlphaLISA Detection Kit

    The AlphaLISA® Human Interleukin-6 (IL6) Detection Kit is designed for detection and quantitation of human IL-6 in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.
    Price Range : 1905.00 USD - 12600.00 USD
  • AlphaLisa Analyte 2

    HVEM (human), lyophilized (AlphaLISA)

    Human HVEM standard, for use in running standard curves in AlphaLISA assays. This standard is already provided in the AlphaLISA human HVEM Detection Kit, but can also be ordered separately.
    List Price : 506.00 USD
  • AlphaLISA Sandwich Anti-AnalyteConjugatedAcceptorBead

    IL-10 (human) AlphaLISA Detection Kit

    The AlphaLISA® Human Interleukin-10 (IL-10) Detection Kit is designed for detection and quantitation of human IL-10 in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.
    Price Range : 1905.00 USD - 12600.00 USD
  • IL-18BP (human) AlphaLISA Detection Kit

    The AlphaLISA® immunoassay kit for human IL-18BP enables the quantitative determination of human interleukin 18-binding protein in serum and cell culture media using a homogeneous AlphaLISA assay (no wash steps).
    Price Range : 939.00 USD - 14000.00 USD
  • Membrane Target Systems

    Membrane Target Systems: Histamine H1 (human) membrane preparation, in CHO-K1 cells. 400 Units.

    Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.
    List Price : 1044.00 USD
  • LANCE Ultra Biomarker

    IL-12/p40 (human) LANCE Ultra TR-FRET Detection Kit

    The LANCE® Ultra Human IL-12/p40 Detection Kit is designed for detection and quantitation of human interleukin-12/p40 in buffered solution and cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.
    Price Range : 903.00 USD - 12000.00 USD
  • In vivo Fluorescent Agents

    ProSense Fluorescent Imaging Agent

    Proteases perform a fundamental role in protein regulation. Altered activity of lysosomal cathepsins, a class of protease, can indicate many disease-related processes, such as those involved in cancer, inflammation, arthritis, cardiovascular and many others. The ability to detect and quantify normal as well as altered protease cathepsin activity in vivo allows the progress and severity of these disease states to be tracked and interrogated over time. PerkinElmer’s ProSense® imaging agents are protease activatable NIR fluorescent probes that are optically silent in their intact state and become highly fluorescent following protease-mediated cleavage and activation. ProSense is available in 3 formats; 680, 750 EX, and 750 FAST.
    Price Range : 640.00 USD - 756.00 USD
  • AlphaLISA SureFire Ultra Phospho-protein

    Phospho-PLC G2 (Tyr1197) AlphaLISA SureFire Ultra Detection Kit

    The AlphaLISA® SureFire® Ultra p-PLC G2 (Tyr1197) assay is a sandwich immunoassay for quantitative detection of phospho-PLC G2 (phosphorylated on Tyr1197) in cellular lysates using Alpha Technology.

    Price Range : 526.00 USD - 34900.00 USD
  • Alpha SureFire Ultra Multiplex Phospho/Total ERK1/2 Assay Kit

    The AlphaLISA® SureFire® Ultra™ Multiplex phospho-ERK1/2 (Thr202/Tyr204) + Total ERK assay kit is used to measure both the phosphorylation of ERK1/2 and total levels of endogenous ERK1/2 in cellular lysates. The assay is an ideal system for the screening of modulators of receptor activation (e.g. agonists and antagonists) as well as agents acting intracellularly, such as small molecule inhibitors of signal transduction. The assay will measure ERK1/2phosphorylation by either recombinant or endogenous receptors and can be applied to primary cells.
    Price Range : 995.00 USD - 63800.00 USD
  • TNFα (porcine) AlphaLISA Detection Kit

    The AlphaLISA® immunoassay kit for porcine TNFα enables the detection and quantitation of porcine TNFα in porcine serum, plasma, and, cell lysyate, cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps). The assay shows minimal cross-reactivity with human and bovine TNFα and no cross reactivity towards porcine IFNγ.
    Price Range : 780.00 USD - 25400.00 USD
  • LANCE Ultra Biomarker

    IFN-λ2 (human) LANCE TR-FRET Detection Kit

    The LANCE® Ultra Human IFN-λ2 Detection Kit is designed for detection and quantitation of human interferon λ2 in buffered solution and cell culture media using a homogeneous TR-FRET (no-wash steps, no separation steps) assay.
    Price Range : 1768.00 USD - 12000.00 USD
  • IL-4 (human) AlphaLISA Detection Kit

    The AlphaLISA® Human Interleukin 4 (IL4) Detection Kit is designed for detection and quantitation of human IL4 in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.
    Price Range : 1905.00 USD - 13300.00 USD
  • Receptor-expressing cell lines

    ValiScreen Histamine H1 (human) cell line

    Stable, recombinant ValiScreen® cell line expressing the Histamine H1 receptor, human recombinant in CHO-K1 host cells.

  • Jump to:
Resource Library (534)
Filters:
Resource Library
  • Application Note (17)
  • Article (3)
  • Brochure (1)
  • Case Study (3)
  • Ebook (2)
  • Poster (3)
  • Technical Note (6)
  • White Paper (4)
Events

Sort by

1-25 of 39 Resource Library

  • Jump to: