PerkinElmer

Infectious Disease Research

OF

Because infectious disease research deals with a wide range of viral, bacterial, and fungal pathogens, it demands analytical instruments that are precise but also versatile. Count on our in vivo, in situ, cellular and biochemical research products for infectious disease detection and biomarker quantitation.

Our products for infectious disease research include:

  • LANCE® TR-FRET biomarker detection technology
  • AlphaLISA® Immunoassay kits
  • DELFIA® (dissociation-enhanced lanthanide fluorescence immunoassay) TRF ELISA alternative technology
  • Cellular and in vivo imaging systems
  • Bioluminescent bacterial strains

This product portfolio meets the needs of many applications for infectious disease detection and research:

  • Detection of bacterial infections (including E. coli), viral infections (including Coronavirus, Zika, Hepatitis B and C, Epstein-Barr, HIV, and H1N1), and of fungal infections
  • Quick quantitation of biomarkers for infectious disease and pathogenesis in human and plant samples, including p24 and p27 viral proteins
  • Monitoring acute and chronic infection and therapeutic treatment in animal models in real time
  • Quantitative assessment and growth inhibition with our gram negative and gram positive bacteria labeled with luciferase
  • Phenotypic analysis

Products & Services (83)
Filters:

Filters :

Product Type
  • Accessories (34)
  • Consumables (2)
  • Instruments (9)
  • Reagents (31)
  • Software and Informatics (7)
Assay Target
  • HBeAg (1)
  • HBsAg (2)
  • HCV cAg (1)
  • Influenza A NP (1)
  • p24 (2)
Target Species
  • Human (2)
Application
  • Immunohistochemistry (IHC) (8)
  • In situ hybridization (ISH) (8)
  • Protein Analysis & Detection (7)
Therapeutic Area
  • Bacterial infection (14)
  • Virology (4)
Product Brand Name
  • AlphaLISA (7)
  • Ancillary Products (2)
  • IVIS (8)
  • Opera Phenix (1)
  • Operetta (29)
  • Operetta CLS AND Opera Phenix (7)
  • TSA (8)
  • XenoLight (14)
Detection Method
  • Alpha (7)
  • Chromogenic (2)
  • Fluorescence (9)
  • Transmission (1)
Volume Capacity
  • 150 µL (2)
Fluorophore
  • Coumarin (1)
  • Cy3 (2)
  • Cy5 (2)
  • Fluorescein (1)
Assay points(200-50,000)
  • 100 (4)
  • 500 (6)
  • 5000 (6)
Assay Target Class
  • Protein (7)
Automation Compatible
  • Yes (8)
Experimental Type
  • In vitro (2)
Format
  • Microplates (2)
  • Slides (8)
Imaging Modality
  • Bioluminenscence (14)
  • High Content (1)
  • microCT Imaging (1)
  • Optical Imaging (8)
Length
  • 51-100 (8)
  • 101-200 (1)
Model Compatible With
  • Operetta (30)
  • Operetta CLS AND Opera Phenix (8)

1-12 of 83 Products & Services

Sort by

  • 1000x1000_Opera_Phenix

    Opera Phenix High-Content Screening System

    The Opera Phenix High Content Screening System is the premier confocal solution for today's most demanding high content applications. Drawing on over a decade of experience with the industry-leading Opera® High Content Screening System, the Opera Phenix is designed for high-throughput, phenotypic screening and assays involving complex disease models, such as live cells, primary cells and microtissues.
  • IVIS SpectrumCT 2D/3D Optical/CT In Vivo Imaging System

    IVIS SpectrumCT In Vivo Imaging System

    The IVIS® SpectumCT preclinical in vivo imaging system expands upon the versatility of the IVIS Spectrum by offering 2D and 3D imaging capabilities but includes integrated low-dose microCT ideal for longitudinal studies. The system provides researchers with greater insights into complex biological systems by enabling simultaneous molecular and anatomical non-invasive imaging in animal models.
  • IVIS Lumina HT High Throughput Benchtop 2D Optical Imaging System

    IVIS Lumina LT In Vivo Imaging System

    The IVIS® Lumina LT Series III pre-clinical in vivo imaging system offers the industries most sensitive benchtop platform at an entry level price.
  • IVIS Lumina S5 high throughput, high sensitivity optical in vivo imaging system

    IVIS Lumina S5 Imaging System

    The IVIS® Lumina S5 high-throughput 2D optical imaging system combines high-sensitivity bioluminescence and fluorescence in a benchtop format. With an expanded 5 mouse field of view for 2D optical imaging plus our unique line of accessories to accelerate setup and labeling, it has never been easier or faster to get robust data—and answers—on anatomical and molecular aspects of disease.
  • IVIS Spectrum In Vivo Imaging System

    IVIS Spectrum In Vivo Imaging System

    The IVIS® Spectrum in vivo imaging system combines 2D optical and 3D optical tomography in one platform. The system uses leading optical technology for preclinical imaging research and development ideal for non-invasive longitudinal monitoring of disease progression, cell trafficking and gene expression patterns in living animals.
  • IVIS Lumina XRMS 2D Optical Imaging System with Integrated X-ray

    IVIS Lumina XRMS In Vivo Imaging System

    Industry leading Fluorescence, Bioluminescence and X-Ray Imaging - All-In-One benchtop instrument! The IVIS® Lumina XRMS (x-ray multi-species optical imaging system) adds to the versatility of the IVIS Lumina XR by offering the flexibility to image large animals up to 500 grams with precise optical and X-Ray overlay.
  • IVIS Lumina X5 in vivo imaging system

    IVIS Lumina X5 Imaging System

    High-Sensitivity Optical Meets High-Resolution X-ray

    The IVIS® Lumina X5 high-throughput 2D optical imaging system combines high-sensitivity bioluminescence and fluorescence with high-resolution x-ray into a compact system that fits on your benchtop. With an expanded 5 mouse field of view for 2D optical imaging plus our unique line of accessories to accelerate setup and labeling, it has never been easier or faster to get robust data—and answers—on anatomical and molecular aspects of disease.
  • IVIS Lumina HT High Throughput Benchtop 2D Optical Imaging System

    IVIS Lumina III In Vivo Imaging System

    The IVIS® Lumina Series III brings together years of leading optical imaging technologies into one easy to use and exquisitely sensitive bench-top system.
  • IVIS Spectrum In Vivo Imaging System

    IVIS SpectrumBL High-Throughput In Vivo Optical Imaging System

    The IVIS® SpectrumBL is an advanced high-throughput 2D and 3D optical imaging system designed to improve quantitative outcomes of bioluminescent, chemiluminescent and Cerenkov in vivo imaging.
  • AlphaLISA immunoassay kits

    HCV cAg AlphaLISA Detection Kit

    The AlphaLISA® immunoassay kit for HCV cAg enables the quantitative determination of hepatitis C virus core antigen in cell culture media using a homogeneous AlphaLISA assay (no wash steps).
    Price Range : 782.00 USD - 11100.00 USD
  • AlphaLisa Analyte 2

    Hepatitis B Virus s Antigen (HBsAg), lyophilized (AlphaLISA)

    Hepatitis B Virus Surface antigen (HBsAg) standard, for use in running standard curves in AlphaLISA assays. This standard is already provided in the AlphaLISA HBsAg Detection Kit, but can also be ordered separately.
    List Price : 421.00 USD
  • P. aeruginosa bioluminescent bacteria

    Pseudomonas aeruginosa - Xen 41

    P. aeruginosa - Xen41 bioluminescent pathogenic bacteria for in vivo and in vitro drug discovery. This product was derived from parental strain PAO1. P. aeruginosa-Xen41 possesses a stable copy of the Photorhabdus luminescens lux operon on the bacterial chromosome.
  • Jump to:
Business Insights (14)
Filters:

Filters :

Resource Library
  • Application Note (10)
  • Poster (3)
  • White Paper (1)

1-12 of 14 Business Insights

Sort by

  • White Paper

    Streamlining Materials Innovation Processes with Electronic Lab Notebook (ELN) and Data Analytics for Optimum Efficiency

    This paper explores the numerous challenges materials scientists and engineers face, from the time it takes to bring new materials to market to the difficulties delivering suitable formulations and testing against specified criteria, and how those can be resolved.

  • Application Note

    Multiplex 2D Imaging of NIR Molecular Imaging Agents on the IVIS SpectrumCT and FMT 4000

    Epifluorescence (2D) imaging of superficially implanted mouse tumor xenograft models offers a fast and simple method for assessing tumor progression or response to therapy. This approach for tumor assessment requires the use of near infrared (NIR) imaging agents specific for different aspects of tumor biology, and this Application Note highlights the ease and utility of multiplex NIR fluorescence imaging to characterize the complex biology within tumors growing in a living mouse.

  • Application Note

    Phenotypic Profiling of Autophagy using the Opera Phenix High-Content Screening System

    Cells constantly sense their environment and their response is a spatio-temporal summation of all signals. To maintain physiological stability, cells need to adjust to environmental changes, a process called homeostasis. One of the most important processes involved in maintaining homeostasis is autophagy, and its significance was recognized by the award of the Nobel Prize for Physiology in 2016 to Yoshinori Ohsumi for the discovery of its underlying mechanisms. Although this is not fully understood, it is believed that autophagy can prevent tumor development by degrading, for example, damaged organelles and protein aggregates.

  • Application Note

    Vascular Imaging Probes For Oncology and Inflammation Using the IVIS Spectrum

    Optical-based in vivo imaging of vascular changes and vascular leak is an emerging modality for studying altered physiology in a variety of different cancers and inflammatory states. A number of fluorescent imaging probes that circulate with the blood, but have no target selectivity, have been used to detect tumor leakiness as an indication of abnormal tumor vasculature. Inflammation is also characterized by distinct vascular changes, including vasodilation and increased vascular permeability, which are induced by the actions of various inflammatory mediators. This process is essential for facilitating access for appropriate cells, cytokines, and other factors to tissue sites in need of healing or protection from infection. This application note investigates the use of three fluorescent imaging probes, to detect and monitor vascular leak and inflammation in preclinical mouse breast cancer models.

  • Application Note

    Stem Cell Research and Regenerative Medicine

    With the potential to treat a wide range of disease, from organ damage to congenital defects, stem cell research and tissue engineering form the underlying basis of regenerative medicine. Significant advances in the science of skin regeneration, for example, have now made it possible to develop and grow artificial skin grafts in a lab for treatment of burn victims. Other therapeutic applications include the use of stem cells to treat and repair central nervous system diseases such as ischemia and cerebral palsy, cardiovascular diseases, as well as autoimmune diseases including type I diabetes.

  • Application Note

    Distinguishing Cell Types by Phenotypic Profiling of the Nucleus

    The promise of high-content screening is the acceleration of discovery by extracting as much relevant information as possible from cells. Nevertheless, a large percentage of high-content screens analyze only a small number of image-based properties. As a result, valuable information from precious cells and disease models is not utilized. As nearly all screening approaches require a nuclear counterstain such as Hoechst to facilitate segmentation, phenotypic profiling of the nuclei can offer new and additional perspectives on assays at no extra cost.

  • Application Note

    Imaging Bile Canaliculi in 3D Liver Microtissues using the Opera Phenix HCS System

    Analyzing transport of biliary metabolites is essential to predict pharmacokinetics and hepatotoxicity during drug development. A functional impairment of hepatobilary transporters, such as bile salt export pump (BSEP) and multidrug resistance-associated protein 2 (MRP-2), is strongly associated with an increased risk of cholestatic liver injury. Here, we describe a 3D high-content screening assay to study hepatobiliary transporter function in InSphero human liver microtissues. Confocal imaging and automated image analysis were used to quantify BSEP and MRP-2-mediated efflux of fluorescent substrates into bile canaliculi.

  • Application Note

    Analyzing ERK Signal Transduction in Live Cells Using a FRET-Based Biosensor

    Extracellular signal-regulated kinase (ERK) is a key component in the regulation of embryogenesis, cell differentiation, cell proliferation, and cell death. The ERK signaling pathway is altered in various cancer types and is frequently investigated as a target for therapeutic intervention. This application note describes how a live cell FRET assay to study ERK signaling was performed on the Operetta CLS™ high-content analysis system. The optimized design of the FRET-based biosensor, the high-quality imaging of the Operetta CLS system and the easy-to-use image analysis tools of the Harmony® software contribute to the robustness of the high-content assay.

  • Application Note

    Measuring FRET using the Opera Phenix High-Content Screening System

    Fundamental processes in living cells, such as apoptosis and signal transduction are controlled by proteins, often acting in concert with other protein partners through protein-protein interactions (PPIs). Inappropriate protein-protein recognition can fundamentally contribute to many diseases, including cancer. Therefore, inhibiting protein-protein interactions represents an emerging area in drug design.

  • Application Note

    Phenotypic Analysis of Hypertrophy in Human iPSC-Derived Cardiomyocytes

    Learn how a phenotypic screening assay to study time-dependent effects of endothelin-1-induced hypertrophy was set up using human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes. Learn how: The Opera Phenix system has been applied in the field of neurodegenerative diseases. In this assay, the Opera Phenix system is 4 times faster than the previous Opera® system. Primary neuron morphology is analyzed in a straightforward approach using Harmony software. Careful assay optimization can increase throughput, and minimize the data burden, without compromising assay performance.

  • Application Note

    Imaging Hepatocellular Liver Injury using NIR-labeled Annexin V

    Drug induced liver injury (DILI) is a major reason for late stage termination of drug discovery research projects, highlighting the importance of early integration of liver safety assessment in the drug development process. A technical approach for in vivo toxicology determination was developed using Acetaminophen (APAP), a commonly used over-the-counter analgesic and antipyretic drug, to induce acute hepatocellular liver injury.

  • Poster

    Combined efficacy & toxicity imaging following acute 5-FU treatment of HT-29 tumor xenografts

    Cancer chemotherapy can produce severe side effects such as suppression of immune function and damage to heart muscle, gastrointestinal tract, and liver. If serious enough, tissue injury can be a major reason for late stage termination of drug discovery research projects, so it is becoming more important to integrate safety/toxicology assessments earlier in the drug development process. There are a variety of traditional serum markers, tailored mechanistically to specific tissues, however there are no current non-invasive assessment tools that are capable of looking broadly at in situ biological changes in target and non-target tissue induced by chemical insult.

  • Jump to: