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Integrins are a superfamily of transmembrane cell surface receptors that mediate signal transduction, cell-to-cell interaction, and cell-to-extracellular matrix adhesion - key processes for healthy cells as well as progression of disease states such as atherosclerosis and cancer, where integrins contribute to angiogenesis, tumorigenesis, and metastasis.
Among this superfamily, αvβ3 integrin holds promise as a therapeutic target in areas such as immuno-oncology, where αvβ3 integrin may prevent tumors from evading the immune system. PerkinElmer's IntegriSense™ fluorescence probes are designed to target αvβ3 integrin for monitoring tumor growth, angiogenesis and assessing treatment efficacy.
Neutrophil Elastase (NE) is a protease secreted by neutrophils. Neutrophils the first responders of the innate immune system and play a crucial role in fighting invading pathogens. Thought to be indiscriminate killers, research shows neutrophils are implicated in chronic inflammatory diseases and contribute to injury repair.
Better understand neutrophilic response in vivo with Neutrophil Elastase 680 FAST NIR fluorescent probe. Neutrophil Elastase 680 probe can detect NE post-degranulation or netosis from activated neutrophils.
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