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Integrins are a superfamily of transmembrane cell surface receptors that mediate signal transduction, cell-to-cell interaction, and cell-to-extracellular matrix adhesion - key processes for healthy cells as well as progression of disease states such as atherosclerosis and cancer, where integrins contribute to angiogenesis, tumorigenesis, and metastasis.
Among this superfamily, αvβ3 integrin holds promise as a therapeutic target in areas such as immuno-oncology, where αvβ3 integrin may prevent tumors from evading the immune system. PerkinElmer's IntegriSense™ fluorescence probes are designed to target αvβ3 integrin for monitoring tumor growth, angiogenesis and assessing treatment efficacy.
Matrix metalloproteinases (MMPs) are calcium-dependent zinc containing endopeptidases responsible for the degradation of most of extracellular matrix proteins during organogenesis, growth and normal tissue turnover. MMPs play a role in almost every biological cell process from embryo implantation to cell death and have been implicated in a wide range of diseases including inflammation, arthritis, pulmonary disease, cancer and more.
PerkinElmer’s MMPSense NIR activatable fluorescence agents are designed to evaluate many disease related processes including cancer progression, rheumatoid arthritis, pulmonary disease and more as well as evaluating therapeutic efficacy of potential drug candidates.
Neutrophil Elastase (NE) is a protease secreted by neutrophils. Neutrophils the first responders of the innate immune system and play a crucial role in fighting invading pathogens. Thought to be indiscriminate killers, research shows neutrophils are implicated in chronic inflammatory diseases and contribute to injury repair.
Better understand neutrophilic response in vivo with Neutrophil Elastase 680 FAST NIR fluorescent probe. Neutrophil Elastase 680 probe can detect NE post-degranulation or netosis from activated neutrophils.
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