PerkinElmer

Immuno-oncology Reagents

OF

Immuno-oncology (I-O) is a rapidly expanding area of personalized medicine. Researchers are exploring the complex relationship between tumor cells and the immune system within the tumor microenvironment to discover new immuno-oncology targets and therapies.

Targeting immune checkpoint inhibitors, such as PD-1, PD-L1, and CTLA-4, has become pivotal in immunotherapy research, and so have monoclonal antibodies (mAbs), whether naked or conjugated with a chemotherapy agent or radioactive particle. Our immuno-oncology immunoassays and reagents provide tools for high throughput screening, assay development, and biomarker validation. We also offer a range of phosphoprotein assays for monitoring downstream cell signaling.

Alpha

Is a homogeneous, luminescence proximity assay technology. When Alpha Donor and Acceptor beads are brought together, a cascade of chemical reactions is set in motion, creating an amplified signal. These versatile beads are coated with various biomolecules and enable detection of unique biological events. From biomarker detection to inhibitor screening and identification, there’s an AlphaLISA® assay to suit your needs. Plus, Alpha SureFire® Ultra provides no-wash cellular kinase assays for the detection of phosphorylated proteins, allowing you to look at downstream cell signaling events.

LANCE TR-FRET

 

Is a homogeneous proximity assay technology that combines the benefits of time resolution (TR) with fluorescence resonance energy transfer (FRET) principles by using energy donor and energy acceptor fluorophore labels. We offer a selection of LANCE® Ultra TR-FRET biomarker immuno-oncology detection kits as well as an array of kits for cell signaling.

cytox
cytox

Cytotoxicity and Cell Proliferation

Assays are widely used assays not only in immuno-oncology studies, but in the drug discovery process in general. They allow us to monitor cell health giving us key insights on the effectiveness of potential drugs. We offer a range of cytotoxicity and cell proliferation assays, including cell proliferation via DNA synthesis or ATP monitoring. Cell-mediated cytotoxicity, including ADCC and CAR-T cell-mediated lysis, with DELFIA TRF cell-mediated cytotoxicity and CR-51 assays.

OnPoint

Are you working on a novel target? If you are looking to develop your own assay PerkinElmer custom labeling services can label your assay components for use in any of our assay technologies – Alpha, LANCE and DELFIA. Or maybe you are you short on time and need an assay developed quickly? Custom assay development allows our technical experts to develop a custom assay just for your research needs. If you are interested in having your biomolecule custom-labeled or in developing a custom assay, please contact our OnPoint custom team.

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1-25 of 102 Products & Services

  • Alpha SureFire Ultra Multiplex Phospho/Total ERK1/2 Assay Kit

    The AlphaLISA® SureFire® Ultra™ Multiplex phospho-ERK1/2 (Thr202/Tyr204) + Total ERK assay kit is used to measure both the phosphorylation of ERK1/2 and total levels of endogenous ERK1/2 in cellular lysates. The assay is an ideal system for the screening of modulators of receptor activation (e.g. agonists and antagonists) as well as agents acting intracellularly, such as small molecule inhibitors of signal transduction. The assay will measure ERK1/2phosphorylation by either recombinant or endogenous receptors and can be applied to primary cells.
    Price Range : 1114.00 USD - 71400.00 USD
  • Total STAT1 AlphaLISA SureFire Ultra Detection Kit

    The AlphaLISA® SureFire® Ultra™ total STAT1 assay is a sandwich immunoassay for quantitative detection of STAT1 (phosphorylated and non-phosphorylated) in cellular lysates using Alpha Technology. This assay is intended to be a normalization phosphorylation studies.

    This kit has been pre-validated for use in combination with the Pelago Bioscience’s CETSA® (Cellular Thermal Shift Assay) technology. Please note that further assay optimization will be required in order to adapt the kit to your particular cell line and experimental conditions. A valid CETSA® licence from Pelago Bioscience or a single kit agreement is required for using the CETSA® technology.

    Price Range : 619.00 USD - 41100.00 USD
  • Total JNK1/2 AlphaLISA SureFire Ultra Detection Kit

    The AlphaLISA® SureFire® Ultra™ total JNK1/2 assay is a sandwich immunoassay for quantitative detection of JNK1/2 (phosphorylated and non-phosphorylated) in cellular lysates using Alpha Technology. This assay is intended to be a normalization phosphorylation studies.

    This kit has been pre-validated for use in combination with the Pelago Bioscience’s CETSA® (Cellular Thermal Shift Assay) technology. Please note that further assay optimization will be required in order to adapt the kit to your particular cell line and experimental conditions. A valid CETSA® licence from Pelago Bioscience or a single kit agreement is required for using the CETSA® technology.

    Price Range : 619.00 USD - 41100.00 USD
  • AlphaLISA phospho-SYK detection kit

    Total TBK1 AlphaLISA SureFire Ultra Detection Kit

    The AlphaLISA® SureFire® Ultra™ total TBK1 assay is a sandwich immunoassay for quantitative detection of TBK1 (phosphorylated and non-phosphorylated) in cellular lysates using Alpha Technology. This assay is intended to be a normalization phosphorylation studies.

    This kit has been pre-validated for use in combination with the Pelago Bioscience’s CETSA® (Cellular Thermal Shift Assay) technology. Please note that further assay optimization will be required in order to adapt the kit to your particular cell line and experimental conditions. A valid CETSA® licence from Pelago Bioscience or a single kit agreement is required for using the CETSA® technology.

    Price Range : 619.00 USD - 41100.00 USD
  • AlphaLISA phospho-SYK detection kit

    Total JAK2 AlphaLISA SureFire Ultra Detection Kit

    The AlphaLISA® SureFire® Ultra™ total JAK2 assay is a sandwich immunoassay for quantitative detection of JAK2 (phosphorylated and non-phosphorylated) in cellular lysates using Alpha Technology. This assay is intended to be a normalization phosphorylation studies.

    Price Range : 619.00 USD - 41100.00 USD
  • AlphaLISA phospho-SYK detection kit

    Phospho-TBK1 (Ser172) AlphaLISA SureFire Ultra Detection Kit

    The AlphaLISA® SureFire® Ultra™ p-TBK1 (Ser172) assay is a sandwich immunoassay for quantitative detection of phospho-TBK1 (phosphorylated on Ser172) in cellular lysates using Alpha Technology.

    Price Range : 619.00 USD - 41100.00 USD
  • AlphaLisa Analyte 2

    IL-3 (mouse), lyophilized (AlphaLISA)

    Mouse IL-3 standard, for use in running standard curves in AlphaLISA® assays. This standard is already provided in the AlphaLISA Mouse IL-3 Detection Kit but can also be ordered separately.
    List Price : 688.00 USD
  • AlphaLISA HIV 1 p24 detection kit

    IFNβ (mouse) AlphaLISA Detection Kit

    The AlphaLISA® mouse Interferon β (IFNβ) Detection Kit is designed for detection and quantitation of mouse IFNβ in buffered solution, or cell culture in a homogeneous AlphaLISA assay (no wash steps).

    Price Range : 1779.00 USD - 14200.00 USD
  • AlphaLISA HIV 1 p24 detection kit

    IL-3 (human) AlphaLISA Detection Kit

    The AlphaLISA® human Interleukin-3 (IL-3) Detection Kit is designed for detection and quantitation of human IL-3 in buffered solution, or cell culture in a homogeneous AlphaLISA assay (no wash steps).

    Price Range : 1779.00 USD - 17000.00 USD
  • AlphaLISA HIV 1 p24 detection kit

    PD-1/PD-L1 (cyno) AlphaLISA Binding Kit

    The AlphaLISA® cyno PD-1/PD-L1 binding kit is designed for the detection of binding activity between cyno PD-1 and PD-L1, using a fast and simple homogeneous AlphaLISA assay (no wash steps). This assay can be used to screen for small molecules that inhibit binding, as a competitive ligand binding (CLB) assay to screen therapeutic blocking antibodies, and for potency assays.

    Price Range : 2977.00 USD - 14800.00 USD
  • AlphaLISA HIV 1 p24 detection kit

    CD28/CD86 (human) AlphaLISA Binding Kit

    The AlphaLISA® human CD28/CD86 binding kit is designed for the detection of binding activity between human CD28 and CD86, using a fast and simple homogeneous AlphaLISA assay (no wash steps). This assay can be used to screen for small molecules that inhibit binding, as a competitive ligand binding (CLB) assay to screen therapeutic blocking antibodies, and for potency assays.

    Price Range : 2977.00 USD - 14800.00 USD
  • IL-2 (mouse) AlphaLISA Detection Kit

    The AlphaLISA® Mouse Interleukin-2 (IL-2) Detection Kit is designed for detection and quantitation of mouse IL-2 in serum, buffered solution, or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.

    This is a replacement for AL511.

    Price Range : 2133.00 USD - 14200.00 USD
  • AlphaLISA HIV 1 p24 detection kit

    PD-1/PD-L2 (human) AlphaLISA Binding Kit

    The AlphaLISA® human PD-1/PD-L2 binding kit is designed for the detection of binding activity between human PD-1 and PD-L2, using a fast and simple homogeneous AlphaLISA assay (no wash steps). This assay can be used to screen for small molecules that inhibit binding, as a competitive ligand binding (CLB) assay to screen therapeutic blocking antibodies, and for potency assays.
    Price Range : 2977.00 USD - 14800.00 USD
  • AlphaLISA phospho-SYK detection kit

    Total STAT6 AlphaLISA SureFire Ultra Detection Kit

    The AlphaLISA® SureFire® Ultra™ total STAT6 assay is a sandwich immunoassay for quantitative detection of STAT6 (phosphorylated and non-phosphorylated) in cellular lysates using Alpha Technology. This assay is intended to be a normalization phosphorylation studies.

    This kit has been pre-validated for use in combination with the Pelago Bioscience’s CETSA® (Cellular Thermal Shift Assay) technology. Please note that further assay optimization will be required in order to adapt the kit to your particular cell line and experimental conditions. A valid CETSA® licence from Pelago Bioscience or a single kit agreement is required for using the CETSA® technology.

    Price Range : 619.00 USD - 41100.00 USD
  • AlphaLISA phospho-SYK detection kit

    Total p70 S6K AlphaLISA SureFire Ultra Detection Kit

    The AlphaLISA® SureFire® Ultra™ total p70 S6K assay is a sandwich immunoassay for quantitative detection of p70 S6K (phosphorylated and non-phosphorylated) in cellular lysates using Alpha Technology. This assay is intended to be a normalization or control assay in conjunction with the AlphaLISA SureFire phospho-p70 S6K assay.

    This kit has been pre-validated for use in combination with the Pelago Bioscience’s CETSA® (Cellular Thermal Shift Assay) technology. Please note that further assay optimization will be required in order to adapt the kit to your particular cell line and experimental conditions. A valid CETSA® licence from Pelago Bioscience or a single kit agreement is required for using the CETSA® technology.

    Price Range : 619.00 USD - 41100.00 USD
  • AlphaLISA phospho-SYK detection kit

    Total NFκB AlphaLISA SureFire Ultra Detection Kit

    The AlphaLISA® SureFire® Ultra™ total NFκB assay is a sandwich immunoassay for quantitative detection of NFκB (phosphorylated and non-phosphorylated) in cellular lysates using Alpha Technology. This assay is intended to be a normalization or control assay in conjunction with the AlphaLISA SureFire phospho-NFκB assay.
    Price Range : 619.00 USD - 41100.00 USD
  • AlphaLISA phospho-SYK detection kit

    Total EGFR AlphaLISA SureFire Ultra Detection Kit

    The AlphaLISA® SureFire® Ultra™ total EGFR assay is a sandwich immunoassay for quantitative detection of EGFR (phosphorylated and non-phosphorylated) in cellular lysates using Alpha Technology. This assay is intended to be a normalization or control assay in conjunction with the AlphaLISA SureFire phospho-EGFR assay.
    Price Range : 619.00 USD - 41100.00 USD
  • AlphaLISA phospho-SYK detection kit

    Total AKT1/2/3 AlphaLISA SureFire Ultra Detection Kit

    The AlphaLISA® SureFire® Ultra™ total Akt1/2/3 assay is a sandwich immunoassay for quantitative detection of Akt1/2/3 (phosphorylated and non-phosphorylated) in cellular lysates using Alpha Technology. This assay is intended to be a normalization or control assay in conjunction with the AlphaLISA SureFire phospho-Akt1/2/3 assay.

    This kit has been pre-validated for use in combination with the Pelago Bioscience’s CETSA® (Cellular Thermal Shift Assay) technology. Please note that further assay optimization will be required in order to adapt the kit to your particular cell line and experimental conditions. A valid CETSA® licence from Pelago Bioscience or a single kit agreement is required for using the CETSA® technology.

    Price Range : 619.00 USD - 41100.00 USD
  • AlphaLISA phospho-SYK detection kit

    Phospho-SHP-2 (Tyr542) AlphaLISA SureFire Ultra Detection Kit

    The AlphaLISA® SureFire® Ultra™ p-SHP-2 (Tyr542) assay is a sandwich immunoassay for quantitative detection of phospho-SHP-2 (phosphorylated on Tyr542) in cellular lysates using Alpha Technology.
    Price Range : 619.00 USD - 41100.00 USD
  • AlphaLISA phospho-SYK detection kit

    Phospho-SHP-1 (Tyr564) AlphaLISA SureFire Ultra Detection Kit

    The AlphaLISA® SureFire® Ultra™ p-SHP-1 (Tyr564) assay is a sandwich immunoassay for quantitative detection of phospho-SHP-1 (phosphorylated on Tyr564) in cellular lysates using Alpha Technology.
    Price Range : 619.00 USD - 41100.00 USD
  • AlphaLISA phospho-SYK detection kit

    Phospho-SHP-1 (Tyr536) AlphaLISA SureFire Ultra Detection Kit

    The AlphaLISA® SureFire® Ultra™ p-SHP-1 (Tyr536) assay is a sandwich immunoassay for quantitative detection of phospho-SHP-1 (phosphorylated on Tyr536) in cellular lysates using Alpha Technology.
    Price Range : 619.00 USD - 41100.00 USD
  • AlphaLISA phospho-SYK detection kit

    Phospho-EGFR (Tyr1068) AlphaLISA SureFire Ultra Detection Kit

    The AlphaLISA® SureFire® Ultra™ p-EGFR (Tyr1068) assay is a sandwich immunoassay for quantitative detection of phospho-EGFR (phosphorylated on Tyr1068) in cellular lysates using Alpha Technology.
    Price Range : 619.00 USD - 41100.00 USD
  • AlphaLISA phospho-SYK detection kit

    Total eIF2α AlphaLISA SureFire Ultra Detection Kit

    The AlphaLISA® SureFire® Ultra™ total eIF2α assay is a sandwich immunoassay for quantitative detection of eIF2α (phosphorylated and non-phosphorylated) in cellular lysates using Alpha Technology. This assay is intended to be a normalization or control assay in conjunction with the AlphaLISA SureFire phospho-eIF2α assay.

    This kit has been pre-validated for use in combination with the Pelago Bioscience’s CETSA® (Cellular Thermal Shift Assay) technology. Please note that further assay optimization will be required in order to adapt the kit to your particular cell line and experimental conditions. A valid CETSA® licence from Pelago Bioscience or a single kit agreement is required for using the CETSA® technology.

    Price Range : 619.00 USD - 41100.00 USD
  • Phospho-TBK1 (Ser172) LANCE Ultra TR-FRET Detection Kit

    LANCE Ultra phospho-TBK1 (Ser172) kits are designed for the detection of phosphorylated TBK1 in cell lysates using a simple, homogeneous LANCE Ultra assay (no wash steps). This assay is compatible with both adherent and suspension cells.
    Price Range : 1821.00 USD - 8200.00 USD
  • AlphaLISA HIV 1 p24 detection kit

    CD70 (human) AlphaLISA Detection Kit

    The AlphaLISA® immunoassay kit for human CD70 enables the quantitative determination of human CD70 in buffer, cell culture media, and cell lysates using a homogeneous AlphaLISA assay (no wash steps).
    Price Range : 1052.00 USD - 14900.00 USD
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