PerkinElmer

Immuno-oncology Reagents

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Immuno-oncology (I-O) is a rapidly expanding area of personalized medicine. Researchers are exploring the complex relationship between tumor cells and the immune system within the tumor microenvironment to discover new immuno-oncology targets and therapies.

Targeting immune checkpoint inhibitors, such as PD-1, PD-L1, and CTLA-4, has become pivotal in immunotherapy research, and so have monoclonal antibodies (mAbs), whether naked or conjugated with a chemotherapy agent or radioactive particle. Our immuno-oncology immunoassays and reagents provide tools for high throughput screening, assay development, and biomarker validation. We also offer a range of phosphoprotein assays for monitoring downstream cell signaling.

Alpha

Is a homogeneous, luminescence proximity assay technology. When Alpha Donor and Acceptor beads are brought together, a cascade of chemical reactions is set in motion, creating an amplified signal. These versatile beads are coated with various biomolecules and enable detection of unique biological events. From biomarker detection to inhibitor screening and identification, there’s an AlphaLISA® assay to suit your needs. Plus, Alpha SureFire® Ultra™ provides no-wash cellular kinase assays for the detection of phosphorylated proteins, allowing you to look at downstream cell signaling events.

Suggested Products

PD-1/PD-L1 (mouse) AlphaLISA Binding Kit, 500 Assay Points IFN-γ (human) AlphaLISA Detection Kit, 500 Assay Points PD-L1 (human) AlphaLISA Detection Kit, 100 assay points Human FcGR3B (CD16b) AlphaLISA Binding Kit, 500 Assay Points CTLA4-CD86 AlphaLISA Binding Kit, 500 assay points AlphaLISA SureFire Ultra p-STAT3 (Tyr705) Assay Kit - High Volume AlphaLISA SureFire Ultra p-AKT1/2/3 (Thr308) Assay Kit - High Volume

Suggested Content

Rapid, No-wash Measurement of Immune Checkpoint Molecules and Cytokines in Co-cultures of Immune Cells and Cancer Cell Lines Soluble PD-L1 Detection in Cellular Supernatants Using AlphaLISA Evaluating the Specificity of PD-1 and PD-L1 Blocking Antibodies Using AlphaLISA Human and Mouse PD-1/PD-L1 Binding Kits

LANCE TR-FRET

 

Is a homogeneous proximity assay technology that combines the benefits of time resolution (TR) with fluorescence resonance energy transfer (FRET) principles by using energy donor and energy acceptor fluorophore labels. We offer a selection of LANCE® Ultra TR-FRET biomarker immuno-oncology detection kits as well as an array of kits for cell signaling.

Suggested Products

FCGR3A/CD16a (176Val/V158) LANCE Ultra TR-FRET Binding Kit, 500 Assay Points FCGR3A/CD16A (176Phe/F158) (human) LANCE Ultra TR-FRET Binding Kit, 500 Assay Points ErbB2 (human) LANCE Ultra TR-FRET Detection Kit, 500 Assay Points EGF-EGFR LANCE Ultra TR-FRET Binding Kit, 500 Assay Points

Suggested Content

LANCE Ultra TR-FRET-based Detection and Modulation of Phosphorylated STAT3 Levels in Human Cells Developing a LANCE TR-FRET Assay for Screening PD-1 and PD-L1 Binding Inhibitors Measuring PD-L1 and PD-1 Expression in Human Cells with LANCE Ultra TR-FRET
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Cytotoxicity and Cell Proliferation

Assays are widely used assays not only in immuno-oncology studies, but in the drug discovery process in general. They allow us to monitor cell health giving us key insights on the effectiveness of potential drugs. We offer a range of cytotoxicity and cell proliferation assays, including cell proliferation via DNA synthesis or ATP monitoring. Cell-mediated cytotoxicity, including ADCC and CAR-T cell-mediated lysis, with DELFIA TRF cell-mediated cytotoxicity and CR-51 assays.

Suggested Products

DELFIA® EuTDA Cytotoxicity Reagents DELFIA®Cell proliferation kit, 10 x 96 wells ATPlite 1step Luminescence Assay System, 10 mL ATP Assay Kit ATPlite 1step 3D, 10 mL kit

Suggested Content

A Cell-Based DELFIA Proliferation Assay for Measurement of DNA Synthesis in Microplate Format Comparison of Luciferase-based Technologies for Measuring Cell Proliferation and Cytotoxicity ATPlite Assay Performance in Human Primary Cells

OnPoint

Are you working on a novel target? If you are looking to develop your own assay PerkinElmer custom labeling services can label your assay components for use in any of our assay technologies – Alpha, LANCE and DELFIA. Or maybe you are you short on time and need an assay developed quickly? Custom assay development allows our technical experts to develop a custom assay just for your research needs. If you are interested in having your biomolecule custom-labeled or in developing a custom assay, please contact our OnPoint custom team.

Suggested Products

Custom Reagent Labeling - Alpha
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