PerkinElmer

Immuno-oncology Reagents

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Immuno-oncology (I-O) is a rapidly expanding area of personalized medicine. Researchers are exploring the complex relationship between tumor cells and the immune system within the tumor microenvironment to discover new immuno-oncology targets and therapies.

Targeting immune checkpoint inhibitors, such as PD-1, PD-L1, and CTLA-4, has become pivotal in immunotherapy research, and so have monoclonal antibodies (mAbs), whether naked or conjugated with a chemotherapy agent or radioactive particle. Our immuno-oncology immunoassays and reagents provide tools for high throughput screening, assay development, and biomarker validation. We also offer a range of phosphoprotein assays for monitoring downstream cell signaling.

AlphaLISA_general
AlphaLISA_general

Alpha

Is a homogeneous, luminescence proximity assay technology. When Alpha Donor and Acceptor beads are brought together, a cascade of chemical reactions is set in motion, creating an amplified signal. These versatile beads are coated with various biomolecules and enable detection of unique biological events. From biomarker detection to inhibitor screening and identification, there’s an AlphaLISA® assay to suit your needs. Plus, Alpha SureFire® Ultra provides no-wash cellular kinase assays for the detection of phosphorylated proteins, allowing you to look at downstream cell signaling events.

LANCE Biomarker
LANCE Biomarker

LANCE TR-FRET

 

Is a homogeneous proximity assay technology that combines the benefits of time resolution (TR) with fluorescence resonance energy transfer (FRET) principles by using energy donor and energy acceptor fluorophore labels. We offer a selection of LANCE® Ultra TR-FRET biomarker immuno-oncology detection kits as well as an array of kits for cell signaling.

cytox
cytox

Cytotoxicity and Cell Proliferation

Assays are widely used assays not only in immuno-oncology studies, but in the drug discovery process in general. They allow us to monitor cell health giving us key insights on the effectiveness of potential drugs. We offer a range of cytotoxicity and cell proliferation assays, including cell proliferation via DNA synthesis or ATP monitoring. Cell-mediated cytotoxicity, including ADCC and CAR-T cell-mediated lysis, with DELFIA TRF cell-mediated cytotoxicity and CR-51 assays.

OnPoint

Are you working on a novel target? If you are looking to develop your own assay PerkinElmer custom labeling services can label your assay components for use in any of our assay technologies – Alpha, LANCE and DELFIA. Or maybe you are you short on time and need an assay developed quickly? Custom assay development allows our technical experts to develop a custom assay just for your research needs. If you are interested in having your biomolecule custom-labeled or in developing a custom assay, please contact our OnPoint custom team.

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