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Matrix metalloproteinases (MMPs) are calcium-dependent zinc containing endopeptidases responsible for the degradation of most of extracellular matrix proteins during organogenesis, growth and normal tissue turnover. MMPs play a role in almost every biological cell process from embryo implantation to cell death and have been implicated in a wide range of diseases including inflammation, arthritis, pulmonary disease, cancer and more.
PerkinElmer’s MMPSense NIR activatable fluorescence agents are designed to evaluate many disease related processes including cancer progression, rheumatoid arthritis, pulmonary disease and more as well as evaluating therapeutic efficacy of potential drug candidates.
Image and quantify osteoporosis, arthritis, cancer metastases, and other bone diseases, as well as normal bone growth and resorption, in vivo with OsteoSense® Fluorescent Imaging probes. As opposed to other imaging modalities such as CT or x-ray which raise the risk of harmful irradiation to the subject, in vivo fluorescence imaging offers no radiation exposure concerns, and when performed with optimized hydroxyapatite-targeted probes such as OsteoSense, can image and quantify bone growth and elucidate the biology of bone remodeling.
OsteoSense is available in 3 wavelengths: 680, 750, and 800.
In vivo optical imaging of vascular changes and vascular leak is an emerging modality for studying altered physiology in a variety of different cancers and inflammatory states. In oncology, increases in tumor vascular permeability can be an early indicator of tumor angiogenesis. In inflammatory disease increased vascular permeability can indicate alterations in fluid homeostasis in an acute edema response or in chronic organ conditions.
PerkinElmer’s AngioSense® NIR fluorescent probes are designed to evaluate vascular changes to better understand various disease states or provide valuable information on effects of drug candidates earlier in the development process.
Integrins are a superfamily of transmembrane cell surface receptors that mediate signal transduction, cell-to-cell interaction, and cell-to-extracellular matrix adhesion - key processes for healthy cells as well as progression of disease states such as atherosclerosis and cancer, where integrins contribute to angiogenesis, tumorigenesis, and metastasis.
Among this superfamily, αvβ3 integrin holds promise as a therapeutic target in areas such as immuno-oncology, where αvβ3 integrin may prevent tumors from evading the immune system. PerkinElmer's IntegriSense™ fluorescence probes are designed to target αvβ3 integrin for monitoring tumor growth, angiogenesis and assessing treatment efficacy.
Neutrophil Elastase (NE) is a protease secreted by neutrophils. Neutrophils the first responders of the innate immune system and play a crucial role in fighting invading pathogens. Thought to be indiscriminate killers, research shows neutrophils are implicated in chronic inflammatory diseases and contribute to injury repair.
Better understand neutrophilic response in vivo with Neutrophil Elastase 680 FAST NIR fluorescent probe. Neutrophil Elastase 680 probe can detect NE post-degranulation or netosis from activated neutrophils.
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