PerkinElmer

Drug Discovery Screening Reagents

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Drug discovery is a complex, costly and time-consuming undertaking. For research scientists, screening potential candidates is where the journey begins.

Your job is to move from target to hit to candidate quickly and efficiently – with as little wasted resources as possible. Our drug discovery screening reagents do just that. Whether you are doing high throughput screening or focused screening, we offer a wide range of validated reagents and kits in Alpha chemiluminescent, LANCE® TR-FRET, DELFIA® TRF, and other assay technologies to suit you screening assay needs.

Accelerate your workflow with our drug discovery screening reagents while getting consistent, accurate and physiologically relevant results.

AlphaLISA assay principle
AlphaLISA assay principle

Alpha Technology

Virtually anything can be measured with Alpha Technology quickly and easily, including enzymes, receptor-ligand interactions, low-affinity interactions, second messenger levels, DNA, RNA, proteins, protein post-translational modifications, protein:protein interactions, peptides, sugars and small molecules.

  • Ease-of-use: homogeneous, no-wash assay, with no separation steps
  • Fast: results in 3 hours for most applications
  • High sensitivity: detect down to femtogram levels of target
  • Large dynamic range: 4-5 logs
  • Compatible with many samples types: serum, plasma, cerebrospinal fluid (CSF), tissue extracts, cell culture supernatants, cell lysates, and more

Choose the Alpha solution that’s right for you

  • AlphaLISA® – when running large numbers of ELISA from the same sample or working with difficult matrix, serum or plasma
  • AlphaLISA SureFire® Ultra and AlphaScreen® SureFire – an excellent choice for studying pathways or phosphorylated proteins in whole cells, or studying endogenous receptors
  • AlphaPlex – for measuring more than one analyte from the same well, by using the specific wavelengths of Europium, Terbium and Samarium atoms.
  • Alpha SureFire Ultra Multiplex – for measuring two phospho-events or one phospho and a “total” protein control from the same well.
  • AlphaScreen® – perfect for studying fusion-tagged proteins or protein: protein interactions, and for testing cAMP, phosphorylated peptides or samples in a simple matrix. Available as AlphaScreen, AlphaLISA and AlphaPlex products.
  • Alpha Toolbox – when your target doesn’t have an off-the-shelf kit, the toolbox gives you everything you need to create your own. Available as AlphaScreen, AlphaLISA and AlphaPlex products.
  • Alpha Biomarker kits – more than 200 validated and ready to use sandwich immunoassays. Available as AlphaLISA and AlphaPlex products.
LANCE biomarker detection assay principle
LANCE biomarker detection assay principle

LANCE Ultra TR-FRET

From assay development to primary and secondary screening, LANCE Ultra Technology provides researchers with robust and easy-to-use assays adaptable to a variety of targets on a broad range of multimode detectors, with the fastest time-to-results in a commercially-available TR-FRET assay.

LANCE and LANCE (LANthanide Chelate Excitation) Ultra are our TR-FRET (time-resolved fluorescence resonance energy transfer), homogeneous (no wash) technologies. One binding partner of interest is labeled with a donor fluorophore (a LANCE Europium chelate) and a second one is labeled with an acceptor fluorophore (ULight™ dye). Upon excitation at 320-340 nm, energy can be transferred from the donor Europium chelate to the acceptor fluorophore if sufficiently close for FRET (~10 nm). This results in the emission of light detectable at 665 nm.

DELFIA TRF Assay
DELFIA TRF Assay

DELFIA

DELFIA (Dissociation-Enhanced Lanthanide Fluorescence Immunoassay) is a proven, robust immunodetection platform based on time-resolved fluorescence (TRF) detection. This detection method, coupled with the unique chemical properties of lanthanide chelates, makes DELFIA a superior alternative to conventional ELISA for research, drug discovery, and clinical applications.

DELFIA offers a combination of high sensitivity, wide dynamic range and long-lasting stability that traditional ELISA cannot match. 

easylite kinase
easylite kinase

Luminescence Assays

Whether are you looking for a reporter gene assay, ATP monitoring assay, or a kinase activity assay, our luminescence assays provide high sensitivity in a convenient microplate format.
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1-25 of 1475 Products & Services

  • LANCE Ultra Biomarker

    Total EGFR LANCE Ultra TR-FRET Cellular Detection Kit

    LANCE Ultra total EGFR kits are designed for the detection of EGFR (phosphorylated and non-phosphorylated) in cell lysates using a simple, homogeneous LANCE Ultra assay (no wash steps). This assay can be used as a normalizaton assay for phospho-EGFR, and is compatible with both adherent and suspension cells.
    Price Range : 1557.00 USD - 7000.00 USD
  • PerkinElmer

    BTK (human) AlphaLISA Detection Kit

    The AlphaLISA® immunoassay kit for human Bruton's tyrosine kinase (BTK) enables the quantitative determination of human BTK in buffer and cell lysates using a homogeneous AlphaLISA assay (no wash steps).
    Price Range : 893.00 USD - 12600.00 USD
  • LANCE Ultra Phopho-protein

    Phospho-SMAD3 (Ser423/425) LANCE Ultra TR-FRET Cellular Detection Kit

    LANCE Ultra phospho-SMAD3 (Ser423/425) kits are designed for the detection of SMAD3 (phosphorylated at residue S423/S425) in cell lysates using a simple, homogeneous LANCE Ultra assay (no wash steps). This assay is compatible with both adherent and suspension cells.
    Price Range : 1557.00 USD - 7000.00 USD
  • AlphaLISA SureFire Ultra total-protein

    AlphaLISA SureFire Ultra Total GAPDH (Human/Mouse) Assay Kit

    The AlphaLISA® SureFire® Ultra Mouse/Human GAPDH assay is a sandwich immunoassay for quantitative detection of human or mouse GAPDH in cellular lysates using Alpha Technology. This assay is intended to be used as a normalization assay.
    Price Range : 526.00 USD - 33600.00 USD
  • AlphaLISA SureFire Ultra total-protein

    Total 4E-BP1 AlphaLISA SureFire Ultra Detection Kit

    The AlphaLISA® SureFire® Ultra™ total 4E-BP1 assay is a sandwich immunoassay for quantitative detection of 4E-BP1 (phosphorylated and non-phosphorylated) in cellular lysates using Alpha Technology. This assay is intended to be a normalization phosphorylation studies.

    Price Range : 526.00 USD - 34900.00 USD
  • PerkinElmer

    BTK (human), liquid (AlphaLISA)

    Recombinant human BTK standard, for use in no-wash AlphaLISA quantitation assays. This standard is already included in the AlphaLISA human BTK detection kit, but can also be ordered separately.
    List Price : 867.00 USD
  • LANCE Ultra Phopho-protein

    Phospho-EGFR (Tyr1068) LANCE Ultra TR-FRET Cellular Detection Kit

    LANCE Ultra phospho-EGFR (Tyr1068) kits are designed for the detection of EGFR (phosphorylated at residue Y1068) in cell lysates using a simple, homogeneous LANCE Ultra assay (no wash steps). This assay is compatible with both adherent and suspension cells.
    Price Range : 1557.00 USD - 7000.00 USD
  • Streptavidin-coated Alpha Donor Bead

    AlphaScreen Streptavidin Donor beads

    Alpha Donor beads coated with streptavidin, for biotinylated biomolecules for use in Alpha no-wash assays.
    Price Range : 429.00 USD - 12000.00 USD
  • AlphaLisa Analyte 2

    PDGF (BB dimer) (human), lyophilized (AlphaLISA)

    Human PDGF (BB homodimer) standard, for use in running standard curves in AlphaLISA assays. This standard is already provided in the AlphaLISA human PDGF Detection Kit, but can also be ordered separately.
    List Price : 352.00 USD
  • AlphaLISA Binding

    FcγR3B (CD16b) AlphaLISA Binding Kit

    The AlphaLISA FCGR3B (CD16b) binding kit is designed for the detection of binding between FcγR3B (CD16b) and human IgG Fc fragment using a homogeneous AlphaLISA assay (no wash steps). This assay can facilitate the design and development of antibody therapeutics using a competition assay format.
    Price Range : 2529.00 USD - 12600.00 USD
  • LANCE Ultra Biomarker

    Total eIF2α LANCE Ultra TR-FRET Detection Kit

    LANCE Ultra Total eIF2α kits are designed for the detection of total eIF2α (phosphorylated and non-phosphorylated) in cell lysates using a simple, homogeneous LANCE Ultra assay (no wash steps). This assay can be used as a normalization assay for phospho-eIF2α detection, and is compatible with both adherent and suspension cells.
    Price Range : 1557.00 USD - 7000.00 USD
  • Photo of Alpha CETSA 500 point kit

    Alpha CETSA Target Engagement Toolbox Assay Kit (Anti-mouse IgG Donor/Anti-rabbit IgG Acceptor)

    Measure binding of small molecule drug candidates to target protein in a cellular environment with Alpha CETSA® target engagement assays. For use in combination with Pelago Bioscience's CETSA® (Cellular Thermal Shift Assay) technology, this kit provides a convenient no-wash assay for detection and quantitation of small molecule binding to target protein, and can be used in hit identification, hit confirmation, and lead optimization studies for increased confidence and better prediction early in the drug discovery process.
    Price Range : 1747.00 USD - 20900.00 USD
  • AlphaLISA Sandwich Anti-AnalyteConjugatedAcceptorBead

    ICAM-1 (human) AlphaLISA Detection Kit

    The AlphaLISA® Human Intercellular Adhesion Molecule-1 (ICAM-1) Detection Kit is designed for detection and quantitation of human ICAM-1 in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay. The antibodies target the extracellular domain of ICAM-1. The analyte in this kit consists of the extracellular domain of human ICAM-1.
    Price Range : 3470.00 USD - 27100.00 USD
  • AlphaLISA Sandwich Anti-AnalyteConjugatedAcceptorBead

    IL-10 (human) AlphaLISA Detection Kit

    The AlphaLISA® Human Interleukin-10 (IL-10) Detection Kit is designed for detection and quantitation of human IL-10 in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.
    Price Range : 1811.00 USD - 12000.00 USD
  • LANCE Ultra ULight™-JAK-1 (Tyr1023) Peptide

    Generic peptide substrate for use in TR-FRET biochemical kinase assays. Refer to Selector Guide for validated kinases. ULight-labeled synthetic peptide derived from amino acids 1015-1027 of human Janus kinase 1 (JAK-1). The ULight-JAK-1 peptide can be phosphorylated at Tyr1023 by JAK3 and several other tyrosine kinases. Peptide sequence: CAGAGAIETDKEYYTVKD
    Price Range : 426.00 USD - 1303.00 USD
  • Alpha Terbium SureFire Ultra Multiplex MPSU

    Alpha SureFire® Ultra™ Multiplex phospho/total BTK Assay Kit

    The Alpha SureFire® Ultra™ Multiplex phospho-BTK (Tyr223) + Total BTK assay kit is used to measure both the phosphorylation (on Tyr223) and total levels of endogenous BTK in cellular lysates. The assay is an ideal system for the screening of modulators of receptor activation (e.g. agonists and antagonists) as well as agents acting intracellularly, such as small molecule inhibitors of signal transduction. The assay will measure BTK phosphorylation by either recombinant or endogenous receptors, and can be applied to primary cells.
    Price Range : 946.00 USD - 60600.00 USD
  • AlphaLISA SureFire Ultra total-protein

    Total p38 MAPK AlphaLISA SureFire Ultra Detection Kit

    The AlphaLISA® SureFire® Ultra Total p38 MAPK assay is a sandwich immunoassay for quantitative detection of p38 MAPK (both phosphorylated and non-phosphorylated) in cellular lysates using Alpha Technology. This assay is intended to be used as a normalization assay for phosphorylation studies.
    Price Range : 526.00 USD - 33600.00 USD
  • AlphaLISA Sandwich Anti-AnalyteConjugatedAcceptorBead

    PDGF (BB dimer) (human) AlphaLISA Detection Kit

    The AlphaLISA® immunoassay kit for human PDGF (BB homodimer) enables the quantitative determination of human platelet-derived growth factor (PDGF) in buffered solution and cell culture supernatants using a homogeneous AlphaLISA assay (no wash steps).
    Price Range : 715.00 USD - 17200.00 USD
  • AlphaLISA Sandwich Anti-AnalyteConjugatedAcceptorBead

    CXCL13 (human) AlphaLISA Detection Kit

    The AlphaLISA® immunoassay kit for human CXCL13 enables the quantitative determination of human C-X-C Motif Chemokine Ligand 13 in serum and cell culture media using a homogeneous AlphaLISA assay (no wash steps).
    Price Range : 893.00 USD - 12800.00 USD
  • PerkinElmer

    Cortisol, liquid (LANCE)

    Cortisol standard, for use in running standard curves in LANCE Ultra TR-FRET assays. This standard is already provided in the LANCE Ultra Cortisol Detection Kit, but can also be ordered separately.
    List Price : 815.00 USD
  • AlphaLISA Sandwich Anti-AnalyteConjugatedAcceptorBead

    Transthyretin (human) AlphaLISA Detection Kit

    The AlphaLISA® immunoassay kit for human transthyretin enables the quantitative determination of human transthyretin (TTR) in buffer, serum, cell culture media, and cell lysates using a homogeneous AlphaLISA assay (no wash steps).
    Price Range : 893.00 USD - 11400.00 USD
  • AlphaLISA Sandwich Anti-AnalyteConjugatedAcceptorBead

    MMP-23 (human) AlphaLISA Detection Kit

    The AlphaLISA® immunoassay kit for human matrix metalloproteinase 23 (MMP-23) enables the quantitative determination of human MMP-23 in buffer, serum, cell culture media, and cell lysates using a homogeneous AlphaLISA assay (no wash steps).
    Price Range : 857.00 USD - 12600.00 USD
  • LANCE Ultra Biomarker

    Total SLP-76 LANCE Ultra TR-FRET Cellular Detection Kit

    LANCE Ultra total SLP-76 kits are designed for the detection of SLP-76 (phosphorylated and non-phosphorylated) in cell lysates using a simple, homogeneous LANCE Ultra assay (no wash steps). This assay can be used as a normalizaton assay for phospho-SLP-76, and is compatible with both adherent and suspension cells.
    Price Range : 1557.00 USD - 7000.00 USD
  • AlphaLISA SureFire Ultra total-protein

    Total KAP1 AlphaLISA SureFire Ultra Detection Kit

    The AlphaLISA® SureFire® Ultra™ total KAP1 assay is a sandwich immunoassay for quantitative detection of KAP1 (phosphorylated and non-phosphorylated) in cellular lysates using Alpha Technology. This assay is intended to be a normalization phosphorylation studies.

    Price Range : 526.00 USD - 34900.00 USD
  • AlphaLISA Sandwich Anti-AnalyteConjugatedAcceptorBead

    IL-17 (human) AlphaLISA Detection Kit

    The AlphaLISA® Human Interleukin-17 (IL-17, IL17A) Detection Kit is designed for detection and quantitation of human IL-17 in serum, buffered solution or cell culture medium in a homogeneous (no-wash steps, no separation steps) assay.
    Price Range : 1811.00 USD - 12000.00 USD
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