Drug Discovery Reagents

Drug discovery starts with an understanding of the basics of diseases and disease pathways. Throughout the process of unraveling the complexity of disease pathways, identifying and characterizing targets, high throughput screening, and lead optimization PerkinElmer has the assays you can count on.

PerkinElmer's drug discovery reagents cover a wide array of applications ranging from immunoassays platforms and kinase assays to reporter gene, cytotoxicity and cell proliferation assays. Our easy-to-use platforms provide greater sensitivity, wide dynamic range, and reduced background.

From basic science to high throughput screening and lead optimization, PerkinElmer drug discovery reagents provide easy-to-use next generation assays every step of the way.







Explore Our Reagents By Assay Technology


Alpha Technology

Alpha is a homogeneous, bead-based assay platform offering several advantages over traditional ELISAs. This versatile, easy-to-use platform is suitable for a wide range of applications.

AlphaLISA®, AlphaLISA SureFire® Ultra, Alpha Screen®, AlphaPlex®, and Alpha kits and standalone reagents can be used to detect:

  • Proteins and phosphoproteins
  • Protein: protein interactions – both high and low affinity
  • Receptor-ligand interactions
  • DNA interactions
  • Post-translational protein modifications

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TR-FRET Technology

TR-FRET combines the benefits of Time Resolved Fluorescence (TRF) with those of Forster Resonance Energy Transfer (FRET). PerkinElmer offers two TR-FRET technologies - HTRF® (Homogeneous Time Resolved Technology) and LANCE® (Lanthanide Chelate Excite) Ultra TR-FRET.

HTRF and LANCE Ultra kits and standalone reagents can be used to detect:

  • Proteins and phosphoproteins
  • Protein: protein interactions
  • Receptor-ligand interactions
  • Second messenger levels

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TRF Technology

DELFIA® (Dissociation-Enhanced Lanthanide Fluorescence Immunoassay) is a washed based, time-resolved fluorescence (TRF) detection platform that utilizes fluorescent lanthanide chelates rather than other fluorophores. While superficially quite similar to an ELISA, DELFIA® comes with additional benefits. DELFIA® has a stable, time-resolved fluorescent signal which improves the assay dynamic range.

DELFIA® kits and standalone reagents can be used to detect:

  • Proteins and phosphoproteins
  • Protein: protein interactions
  • Cytotoxicity
  • Cell proliferation

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Luminescence Assays

Luminescence assays are used throughout the drug discovery workflow. Our assays are provided a simple, easy-to-use microplate format.

Our luminescence assays include:

  • Reporter gene assays
  • Cytotoxicity and cell proliferation assays
  • Kinase activity assays

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Receptor Cell Lines & Membranes

Receptor Cell Lines & Membranes

Whether you are working with cell-based or biochemical assays, our GPCR overexpressing cell lines and membranes originate from clones carefully selected to produce the most effective assays.

Our cell line clones have been selected to produce the most effective:

  • Radioligand binding
  • GTP binding
  • cAMP activation
  • Calcium flux
  • Downstream phosphorylation measurements

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Radiometric Assays

Radiometric detection remains the most sensitive assay today. We offer scintillation proximity assays (SPAs) and radiolabeled ligands for ligand binding studies, plus a vast array of radiochemicals for all your research needs.

Our products support a range of radiometric assays, including:

  • Scintillation Proximity Assays (SPA)
  • Receptor-Ligand binding assays – using either tritiated and iodinated compounds


Study Target Engagement with CETSA®

The Cellular Thermal Shift Assay (CETSA®) is a unique tool allowing the study of the interaction of ligands with their intended target biomolecules. Particularly relevant in the context of early-stage drug discovery, CETSA® can be combined with proximity-based assays such as Alpha or HTRF, offering distinct advantages to existing techniques that require cloning or purified protein to work.

Alpha- or HTRF-CETSA®:

  • Is a cell-based, physiologically relevant target engagement study tool
  • Uses endogenous protein levels in unmodified or even primary cells
  • Can be applied throughout the drug discovery workflow in a reliable, high-throughput format

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Newest Assays

PerkinElmer R&D scientists focus on developing fully validated, ready-to-use kits and reagents for the hottest new targets. We continue to evolve our product offering as your science evolves.

Our Alpha, HTRF®, LANCE® Ultra TR-FRET, and DELFIA® TRF technologies offer alternatives to standard ELISA assays, each with a larger dynamic range and higher signal-to-noise ratio. Alpha, HTRF and LANCE Ultra TR-FRET have the added advantage of having no wash or separation steps, saving you valuable time.

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PerkinElmer offers a range of ELISA alternative immunoassay technologies that enable selection of the optimal immunoassay platform for your requirements. From sample compatibility to sample volume, throughput, detectable range, signal window, signal stability, reproducibility, automation compatibility, and desired speed of results, PerkinElmer offers immunoassay technology platforms, pre-configured kits, and customizable reagents for superior results.

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Better Microplates Means Better Results

A microplate is a critical part of your discovery process. Microplates have the capability to generate valuable, information-rich data that bring great insights into discovery screening.

Microplate planarity and inaccurate data collection are common issues caused by microplates that are not carefully designed for the unique challenges of sample screening which can result in missed data points, sample re-screening, missed project timelines, and ultimately higher costs.

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Microplate Readers

PerkinElmer offers a family of plate readers focused on performance, versatility, and reliability for today's laboratory needs. Our drug discovery reagents are validated using our microplate readers, ensuring optimal performance when used together.

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OnPoint Custom Solutions

Are you working on a novel target? Need to develop an assay? We’re here to help. Choose between custom labeling or custom assay development. Let our experts

  • Extend your lab's capabilities by labeling your sample so you can develop your own assay – Alpha, HTRF, LANCE Ultra and DELFIA labeling available.
  • Let us develop an assay to your specifications.

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Explore Our Reagents By Target Area

Targeted Protein Degradation Assays & Reagents

Protein homeostasis in the cellular environment is achieved through the ubiquitin-proteasome system (UPS) and the autophagy-lysosomal system (ALS). Together, th ...

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Target Engagement Reagents

The pharmacological validation of the interaction of a ligand with its protein target is referred to as target engagement. Target engagement studies are crucial ...

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Biomarker Detection Reagents

Our biomarker detection reagents and kits are designed to excel in applications that rely on high sensitivity, wide dynamic range, and easy automation. With no ...

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Protein-Protein Interaction Research Reagents

The interactions and binding of proteins are implicated in a large number of biological processes. The need for efficient, highly sensitive assays to study larg ...

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Protein Kinase Research Reagents

Cancer, diabetes, and Alzheimer’s research can benefit from the study of phosphorylation and protein kinase activity. Because of their role in signal transducti ...

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GPCR Research Reagents

G protein-coupled receptors (GPCRs) are the largest family of membrane proteins and the most studied targets in drug discovery. They relay extracellular signals ...

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Epigenetic Research Reagents

As the understanding of the role of epigenetic changes in various disease states advances, the need for high quality reagents that can rapidly identify and vali ...

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Cytokine Research Reagents

Cytokines regulate several physiological and pathological roles including innate immunity, acquired immunity, and many inflammatory responses. PerkinElmer offer ...

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Explore Our Reagents By Therapeutic Area

Immuno-oncology Reagents

Immuno-oncology is a leader in the worldwide drug development pipeline and is at the forefront of cancer research. By giving the immune system tools to detect t ...

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Neuroscience Research Reagents

Over 55 million people worldwide are developing dementia and this number is expected to double by 2050. All the neurodegenerative disorders studies and associat ...

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Cardiovascular Disease Research

Comprising the heart, arteries, veins, and capillaries, the cardiovascular system supplies life-giving blood to the body. Diseases of the cardiovascular system ...

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Metabolic Disease

Metabolic disorders occur when the body's usual metabolic processes are disrupted - numerous molecular pathways and thus, several organs, can be affected. These ...

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Virology Reagents

Viruses and virally transmitted diseases have been impacting human health and well-being for millennia. Some of our greatest scientific challenges and medical t ...

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