DNA Damage and Fluorescence in situ Hybridization

Fluorescence in situ hybridization (FISH) is a powerful technique for detecting RNA or DNA sequences in cells, tissues and tumors. FISH provides a unique link among the studies of cell biology, cytogenetics and molecular genetics. It uses fluorescent probes that only bind to the parts of the chromosome with which they show a high degree of sequence similarity.

High content analysis can be used to identify FISH signals in nuclei as fluorescent spots and can distinguish different samples bound to the chromosomes using different colored fluorescent probes.

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