PerkinElmer

Biologics Immunogenicity and PK/PD

The immunogenic potential of biotherapeutic drug molecules can have an effect at any point from its administration through metabolism and elimination. Therefore, it is important to understand the impact of immunogenicity upon the pharmacokinetic (PK) and pharmacodynamic (PD) properties of a large molecule drug.

Subsequently, the characterization of the effect of anti-drug antibodies (ADA) on the PK is critical. The development of a physiologically relevant PK model in the context of the immunogenicity profile offers significant value to preclinical development.

Technology platforms that enable in vitro, ex vivo, as well as in vivo evaluations encompass a total solution offered by PerkinElmer.

Integrated Laboratory Automation

With dedicated workstations designed for a diverse variety of applications, along with the ability to customize liquid handling workstations based on your needs, PerkinElmer's innovative automated liquid handling solutions enable you to minimize errors, reduce hands-on time, and increase throughput and reproducibility.

With flexibility in throughput, capacity and dynamic volume range, remote error monitoring through a cloud-based platform, high quality manufacturing standards, and outstanding customer service and support, PerkinElmer offers automated liquid handling solutions optimized to meet your laboratory's needs.

  • JANUS® G3 Liquid Handlers
  • Sciclone® G3 Liquid Handlers
  • Zephyr® G3 Liquid Handlers

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Nucleic Acid Analysis and Protein Characterization

PerkinElmer offers automated microfluidic devices, simplifying the analysis of nucleic acid concentration and qualitative assessment of PCR products, and replacing the multiple manual steps of slab gel electrophoresis with high levels of accuracy.

Sample preparation and characterization of proteins for quality by design (QbD) studies are important parts of process development; however, these studies, including design of experiments(DoE), can be time-consuming, and sample analysis can easily exceed the capacity of most labs.

Miniaturization of small-scale protein purification provides greater process optimization with larger QbD and DoE studies allowing for parallel processing of samples for increased statistical significance and a greater breadth of variables within experimental shorter time frames.

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In Vivo Preclinical Imaging Instruments

Delivering fast, longitudinal, real-time quantitative assessment of drug candidates, non-invasive in vivo imaging enables physiological assessment, including:

  • Biodistribution and dosing strategies
  • Efficacy and off-target effects
  • Drug safety and toxicology
  • Pharmacokinetic and pharmacodynamic (PK/PD) profiles in the context of the whole animal
  • Longitudinal studies providing quantitative intrasubject comparisons, enhancing the statistical power of data

Multiparametric data points from fewer subjects enable reduction in animal usage, streamlining drug assessment and lowering costs.

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Live Cell Imaging

Today live-cell imaging assays can be performed using instruments designed specifically for this purpose, as well as with high-content screening systems.

PerkinElmer's dedicated live-cell imaging system, MuviCyte, fits inside an incubator, enabling long term observations under optimal conditions over several days or weeks.

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High Content Screening Analysis

Our high-content screening systems, Opera Phenix Plus and Operetta CLS have the flexibility to run live-cell assays, combining the benefits of observing live-cells over time with the quantitative, multiparametric data analysis required in drug discovery programs.

In addition, the Opera Phenix Plus system is equipped with fast frame rate imaging and has the option of on-board liquid handling to enable "dispense and read" live-cell fast response assays.

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Cellular Imaging Software

Turn your biological data into knowledge.

  • Analyze common assays with more than 30 ready-made solutions, or create your own with simple image-analysis building blocks
  • Easily quantify complex cellular phenotypes based on changes in morphology, fluorescence intensity, intensity distribution, and texture parameters
  • Visualize and analyze your samples in 3D for greater depth of information and insights in a more physiologically relevant context
  • Find images, metadata, and results quickly via the integrated sortable database

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Liquid Chromatography (HPLC & UHPLC)

The need for high performance and reliability are a given for QC labs performing assays to determine the strength and content of drug substances. Our proven, rugged, and reliable Flexar system is the perfect choice when you need fast cycle times, reproducibility, and low carryover. With its elegant streamlined interface, the Flexar range is easy to use and simplifies your day-to-day processes so you can focus on your applications.

Integrated LC tube management for streamlined chromatography UV/Vis and PDA detectors offer fast, sensitive performance for a wide range of applications Hidden plug-and-play drainage automatically interconnects with components added to system Convenient solvent manager with integrated degasser and software communication link.

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