PerkinElmer

Altered Cellular Process

The central nervous system (CNS) is a complex biological system with unique anatomical and physiological characteristics. Although there is still much to be discovered behind the workings of the brain, researchers have pointed to aberrant changes in key cellular processes that contribute to the mechanisms of neurodegenerative disease progression. Among these, critical pathways involved in oxidative stress, mitophagy, cell death, proteostasis, neuropeptide or neurotransmitter deregulation, and others are currently being explored.

We offer reagents, consumables, and instruments for immunoassay readouts and high content imaging to better assess these cellular, molecular, and/or phenotypic changes. The Opera Phenix® High Content Screening System has been used to assess degrees of oligodendrocyte differentiation, calcium flux, neuroprotective effects of certain compounds, neurite growth, and other neurological features with fixed or live-cell imaging.

Explore Our Reagents by Target Area

Biomarker Detection Reagents

Our biomarker detection reagents and kits are designed to excel in applications that rely on high sensitivity, wide dynamic range, and easy automation. With no ...

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Protein-Protein Interaction Research Reagents

The interactions and binding of proteins are implicated in a large number of biological processes. The need for efficient, highly sensitive assays to study larg ...

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Protein Kinase Research Reagents

Cancer, diabetes, and Alzheimer’s research can benefit from the study of phosphorylation and protein kinase activity. Because of their role in signal transducti ...

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GPCR Research Reagents

G protein-coupled receptors (GPCRs) are the largest family of membrane proteins and the most studied targets in drug discovery. They relay extracellular signals ...

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Epigenetic Research Reagents

As the understanding of the role of epigenetic changes in various disease states advances, the need for high quality reagents that can rapidly identify and vali ...

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Cytokine Research Reagents

Cytokines regulate several physiological and pathological roles including innate immunity, acquired immunity, and many inflammatory responses. PerkinElmer offer ...

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Featured Solutions

GPCR Research Reagents

G protein-coupled receptors (GPCRs) are the largest family of membrane proteins and the most studied targets in drug discovery. They relay extracellular signals ...

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