PerkinElmer

ADME/Tox Studies

In the development phase of a new drug product, researchers must examine the activity of a compound in relevant model systems that can mimic human physiology to assess its safety and toxicity. Drug metabolism and pharmacokinetics testing, such as absorption, distribution, metabolism, and excretion (ADME) and toxicology studies, are a critical step in this process.

ADME and toxicology studies are conducted during the preclinical stage of drug development process before filing an Investigational New Drug (IND) application, prior to any clinical trial. Many early candidates are prevented from reaching the market due to inappropriate ADME properties and drug-induced toxicity.

Tools that help to predict the ADME responses early in development present an advantage to researchers as they mitigate the risk of late-stage failure. For example, in vitro metabolite profiling, structural activity elucidation, and drug-drug interaction (DDI) studies are critical for IND and New Drug Application (NDA) submissions during preclinical development. Selecting the most appropriate in vitro assays and animal models is also imperative.

We provide the most comprehensive and innovative line of instrumentation, software, reagents, and consumables, as well as state-of-the-art informatics and services that enable our customers to meet compliance requirements throughout the ADME/tox studies.

Explore Our Solutions

Microplate Readers

Performance, Versatility, and Reliability for Today’s Laboratory Needs As many of you know, microplate readers are instruments used to detect biological, chemic ...

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Drug Discovery Reagents

Drug discovery starts with an understanding of the basics of diseases and disease pathways. Throughout the process of unraveling the complexity of disease pathw ...

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Cell Viability, Proliferation, Cytotoxicity & Metabolism

Monitor cell viability, cell proliferation and metabolic pathways through our diverse selection of radiochemicals, reagents, consumables and detection platforms ...

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High Content Screening & Analysis

High-Content Analysis (HCA) or High-Content Screening (HCS) combines high-throughput automated imaging and analysis to extract quantitative multi-parametric dat ...

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In Vivo Preclinical Imaging Solutions

Tracking, monitoring, and visualizing biological processes and disease progression is key to not only helping you better understand biology, but also crucial in ...

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PhenoLOGIC Machine Learning

PhenoLOGIC™ enables biologists using Harmony to train the software to develop the image analysis algorithms. While other systems may require an image analysis e ...

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Harmony High-Content Imaging and Analysis Software

Easily quantify complex cellular phenotypes with Harmony® high-content analysis software. Harmony software is designed for PerkinElmer high-content screening sy ...

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GMP Radiosynthesis Services

PerkinElmer's experienced chemists will work with you, scientist to scientist, to design and prepare your radiochemical. You'll have access to PerkinElmer's ext ...

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