PerkinElmer

Seamless Science for 3D Cell Models

The journey to discovering novel targets starts with building a deep understanding of the underlying biology. To achieve this, researchers are increasingly looking to 3D cell cultures, microtissues, and organoids to bridge the gap between 2D cell cultures and in vivo animal models. 3D models provide more physiologically relevant conditions than biochemical assays and 2D cell cultures, as they more closely mimic the microenvironment, cell-to-cell interactions, and biological processes that occur in vivo. Plus, they show a higher degree of morphological and functional differentiation.

PerkinElmer takes a solutions-based approach to support customers at every step of the cell culture workflow, from seeding and sample processing to readout and analysis. With our best-in-class instruments, reagents, and informatics-based solutions you can grow, detect, and analyze 3D cell cultures at scale and begin generating more physiologically relevant data to better understand biological processes and make informed decisions.

For research use only. Not for use in diagnostic procedures.

cell workflow infographic

Seed

The first critical step in your 3D cell culture workflow is seeding, using specific methods and growth conditions. Methods are selected depending on the biological question, complexity of the model, and readout technology. Starting with the right cell model, that first needs to be characterized, cells can be grown as single spheroids in an ultra-low attachement (ULA) plate or cultured in hydrogels. Both methods are scalable using liquid handling.

Microplates

Choosing the right microplate is a critical, often overlooked, part of an assay. The right microplate helps provides valuable data, whereas the wrong microplate can lead to missed or inaccurate data leading to missed project timelines and ultimately higher costs. New technologies for drug developmen ...

GrowDex Hydrogels

How to use Growdex hydrogels We offer a range of products for scalable animal-free 3D cell culture applications, providing convenience and consistent results. GrowDex® hydrogels are natural nanofibers of cellulose extracted from wood and sourced from sustainable and responsibly managed forests. Supp ...

JANUS Liquid Handler Workstations

The JANUS® G3 automated liquid handling workstations offer flexible automated sample preparation solutions to meet your specific application needs. The JANUS G3 portfolio includes both dedicated, application-specific workstations and personalized automated solutions. The JANUS G3 workstation can be ...

Relevant Cell Models

Horizon offers a catalogue of more than 3000 off-the-shelf edited cell lines and a variety of gene-modulation reagents. In particular, Horizon’s Edit-R™ All-in-one system and Accell siRNA reagents have been proven to work well with 3D cell models.

Cell Counters

Nexcelom offers a broad range of brightfield, fluorescent, or plate-based automated cell counters that can generate consistent counting results.

Sample Processing

3D cell models usually need to grow for days, or even weeks, before they are ready for read-out. Monitoring that growth and proliferation over this long period of time is critical to preserving your samples so they can progress to imaging readout. Our live-cell imaging systems help to significantly reduce the time and effort needed to quantify key aspects including size, number, growth, or shape. Plus, with our line of innovative reagents, you’ll have the right solutions available to prepare your 3D sample for any readout ― imaging, detection and sequencing.

LabChip GX Touch Nucleic Acid Analyzer

DNA and RNA quantitation and sizing can be done in seconds using automated capillary electrophoresis separation. The LabChip® GX Touch™ nucleic acid analyzer’s microfluidic technology generates high-resolution data and is optimal for NGS library preparation (smear and fragment analysis) and quality ...

MuviCyte Live-Cell Imaging Kit

The MuviCyte™ live-cell imaging system is designed to operate inside your cell-culture incubator, enabling you to maintain your cells under optimal conditions and perform a wide range of assays in a variety of culture vessels. Life science research labs study cellular behaviors and pathways to gain ...

Drug Discovery Reagents

Drug discovery starts with an understanding of the basics of diseases and disease pathways. Throughout the process of unraveling the complexity of disease pathways, identifying and characterizing targets, high throughput screening, and lead optimization PerkinElmer has the assays you can count on. P ...

Cellular Imaging Reagents

PerkinElmer's PhenoVue™ suite of cellular imaging reagents – from cell painting kits to organelle and cell compartment stains to fluorescent labelled secondary antibodies – complements our proven high-content screening instruments and image analysis software. Our PhenoVue reagents are suitable for u ...

Fluorescent Imaging

Celigo is a plate-based benchtop brightfield and fluorescent imaging system designed for whole-well live-cell analysis and cell sample characterization. Celigo images and analyzes cells in various types of vessels without disturbing their natural state.

HIVE scRNAseq Solution

Developed by Honeycomb Biotechnologies, the HIVE™ scRNAseq Solution integrates sample storage and single-cell profiling into a complete workflow, solving the issues that limit single-cell RNA analysis.

Read-Out

Selecting the right method for measuring the biological response of 3D models depends on the question asked and the specifics of the model system used. Whether you’re repeatedly monitoring microtissue size using brightfield imaging or measuring sensitive detection of secreted proteins, each readout type poses unique challenges that can be overcome with the right tools. Our line of sensitive, yet powerful microplate readers and high-content analysis systems, plus innovative reagents, is designed for 3D cell culture detection, and together with our specially designed microplates, can help shed more light on to your sample.

Microplate Readers

As many of you know, microplate readers are instruments used to detect biological, chemical, biochemical or physical events from samples in a microplate. This is where it all starts for your basic research, assay development and therapeutic research. A powerful and reliable plate reader is what you ...

High Content Screening Instruments

High-Content Analysis (HCA) or High-Content Screening (HCS) combines high-throughput automated imaging and analysis to extract quantitative multi-parametric data at the single-cell level. Originally developed as a complementary technology to traditional biochemical high-throughput screening (HTS) in ...

Analysis

It’s not easy to extract information from 3D datasets – readouts and large amounts of data need to be analyzed, and in context. Our scientific software and informatics solutions give you the tools to optimize imaging of 3D cell models and then aggregate, search, mine, and visualize critical data, and turn it into actionable insights.

Harmony High-Content Imaging and Analysis Software

Easily quantify complex cellular phenotypes with Harmony® high-content analysis software. Harmony software is designed for PerkinElmer high-content screening systems.

Signals Image Artist

Signals Image Artist™ is our next generation image analysis and management platform for high-content screening and cell imaging data. Quickly process, analyze, share, and store the vast volumes of data generated by high-content screening and cellular imaging, including live cell imaging, 3D imaging, ...

Signals Vitro Vivo™

Signals VitroVivo is an intuitive, configurable, flexible screening workflow processor coupled with the unparalleled data visualization and analysis capabilities of TIBCO Spotfire.

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