3D cell cultures, microtissues, and organoids are increasingly being used to bridge the gap between 2D cell cultures and in vivo animal models. 3D cell models are more physiologically relevant than biochemical assays and 2D cell cultures, as they more closely represent the microenvironments, cell-to-cell interactions, and biological processes that occur in vivo. 3D cell models show a higher degree of morphological and functional differentiation – again, similar to in vivo cell characteristics.
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