PerkinElmer

3D Cell Culture & Analysis

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3D cell cultures, microtissues, and organoids are increasingly being used to bridge the gap between 2D cell cultures and in vivo animal models. 3D cell models are more physiologically relevant than biochemical assays and 2D cell cultures, as they more closely represent the microenvironments, cell-to-cell interactions, and biological processes that occur in vivo. 3D cell models show a higher degree of morphological and functional differentiation – again, similar to in vivo cell characteristics.

Grow, detect, and analyze 3D cell cultures with our best-in-class solutions, and begin generating more physiologically relevant data that can power better-informed decisions.

3D-Cell-Culture-4
3D-Cell-Culture-4

Grow 3D cell culture with speciality microplates

Our CellCarrier Spheroid ULA microplates enable the use of three-dimensional (3D) cell culture models for cell-based microplate assays. The unique Ultra-Low Attachment (ULA) surface promotes the formation of consistently round spheroids. The optically-clear, round bottom wells produces high-quality imaging results.

Suggested Products

CellCarrier Spheroid ULA 96-well Microplates, pack of 10

Suggested Content

5 Top Tips for a Successful High-content Screening Assay with a 3D Cell Model System 3D Cell Culture Solutions Brochure Automation of 3D Spheroid Production, Cell Culture and Analysis Simplifying microtissue-based screening using automation and the EnSight multimode plate reader Seeing Cell Culture in 3D User's Guide to CellCarrier Spheroid ULA Microplates
3D InSight™ Human Liver Microtissues from InSphero labeled imaged on the Operetta CLS system
3D InSight™ Human Liver Microtissues from InSphero labeled imaged on the Operetta CLS system

Detect with sensitive detection and high-content imaging solutions

Our multimode microplate readers and high-content analysis systems, plus innovative reagents, provide you with highly sensitive solutions for 3D cell culture imaging and detection.
  • Opera Phenix™ high-content screening system is the premier confocal solution for 3D high-content screening, enabling fast multichannel 3D acquisition at high image quality.
  • With its unique combination of technologies, the Operetta CLS™ high-content analysis system provides flexibility, sensitivity, and resolution for 3D imaging.
  • With the EnSight multimode plate reader you can monitor the growth and health of your 3D cell cultures by measuring size, shape, and more using image cytometry. Combine imaging with other technologies such as AlphaLISA® to detect secreted proteins.
  • ATPlite™ 3D and ATPlite 1step 3D reagent kits for cell viability and proliferation provide a simple, robust protocol for ATP-content endpoint measurements of 3D spheroids.

Suggested Products

PreciScan Intelligent Acquisition ATPlite 3D, 300 assay point kit EnSight Multimode Plate Reader Operetta CLS High-Content Analysis System Opera Phenix High-Content Screening System

Suggested Content

5 Top Tips for a Successful High-content Screening Assay with a 3D Cell Model System 3D Cell Culture Solutions Brochure Proliferation and Cell Death Analyses of 3D Cultures Using ATPlite 3D Rapid, reliable measurement of cellular proliferation and toxic compound effects on 3D spheroid cultures grown from multiple cancer cell lines with ATPlite 3D and ATPlite 1step 3D Improved 3D Imaging with Opera Phenix HCS System Imaging Bile Canaliculi in 3D Liver Microtissues Seeing Cell Culture in 3D
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3D-Cell-Culture-6

Analyze with powerful and intuitive informatics solutions to uncover new insights

Our scientific software and informatics solutions give you the tools to optimize imaging of 3D cell models and then aggregate, search, mine, and visualize critical data - and turn it into actionable insights.
  • Turn data into understanding with the intuitive Harmony™ imaging and analysis software for the Opera Phenix and Operetta CLS systems. You can accelerate 3D image acquisition and analysis, better understand spatial relationships, discover new perspectives not visible in 2D and measure volume and morphology in 3D. Optional PreciScan™ intelligent acquisition lets you pre-scan to locate your sample in the well for significantly reduced acquisition and analysis times.
  • Manage the large amounts of data that high-content analysis generates with Columbus™ image data storage and analysis software. Add cluster computing capabilities for even greater power when acquiring large datasets for working with 3D samples.

Suggested Products

Columbus Image Data Storage and Analysis System

Suggested Content

Clearing Strategies for 3D Spheroids 3D Volumetric and Zonal Analysis of Solid Spheroids 5 Top Tips for a Successful High-content Screening Assay with a 3D Cell Model System 3D Cell Culture Solutions Brochure Seeing Cell Culture in 3D Imaging Bile Canaliculi in 3D Liver Microtissues Quantitative Analysis of 3D Microtissue Growth and Biomarker Intensity
Products & Services (9)
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1-9 of 9 Products & Services

  • Operetta CLS High-Content Analysis System
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    Operetta CLS High-Content Analysis System

    HH16000000
    Uncover deep biological understanding in your everyday assays and innovative applications using the Operetta CLS™ high-content analysis system. Featuring a unique combination of technologies, the system delivers all the speed, sensitivity and resolution you need to reveal fine sub-cellular details. And with our simple, powerful Harmony 4.5 software, Operetta CLS™ lets you find even subtle phenotypic changes.
  • EnSight Multimode Plate Reader
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    EnSight Multimode Plate Reader

    HH34000000
    The EnSight™ multimode plate reader offers HTS Alpha, Ultra-sensitive Luminescence and fast well-imaging technologies alongside conventional multimode detection technologies. Imaging & online data analysis is fast: a 384-well plate can be imaged in less than 5 mins. The system’s modular design, combined with workflow-based Kaleido™ data acquisition & analysis software, gives a truly versatile plate reader that gets users productive quickly.
  • Opera Phenix High-Content Screening System
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    Opera Phenix High-Content Screening System

    HH14000000

    The Opera Phenix HCS system has been replaced by the Opera Phenix Plus system.

    Please visit the Opera Phenix Plus webpage.

  • ATPlite 1-step 3D kit
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    ATPlite 1step 3D, 10 mL kit

    6066736
    ATP-monitoring luminescence assay for quantitative evaluation of proliferation and cytotoxicity of mammalian cells cultured in 3D spheroids. The 1-step format only requires one addition step, and can be used for continuous processing.
    List Price : 83.00 USD
  • ATPlite 3D Kit
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    ATPlite 3D, 300 assay point kit

    6066943
    ATP-monitoring luminescence assay for quantitative evaluation of proliferation and cytotoxicity of mammalian cells cultured in 3D spheroids.
    List Price : 163.00 USD
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    CellCarrier Spheroid ULA 96-well Microplates

    6055330 , 6055334
    Round bottom, clear 96-well polystyrene microplates coated with Ultra Low Attachment (ULA) surface for 3D culture of mammalian cells. This ULA coating in round-bottom wells facilitates formation of round spheroids after incubating seeded cells.
    Price Range : 267.00 USD - 1120.00 USD
  • Harmony Software 1
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    Harmony High-Content Imaging and Analysis Software

    HH17000010 , HH17000001 , HH17000012
    Easily quantify complex cellular phenotypes with Harmony® high-content analysis software. Harmony software is designed for PerkinElmer high-content screening systems.
  • Columbus Image Data Storage and Analysis System
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    Columbus Image Data Storage and Analysis System

    Columbus , ColumbusPlus
    Our Columbus™ Image Data Storage and Analysis system is an instrument agnostic image analysis and management platform. The Columbus system is the only system that provides universal high-volume image data storage and analysis and brings access to images from a wide range of sources including all major high content screening instruments.
  • PreciScan_Software
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    PreciScan Intelligent Acquisition

    HH17000003
    Harness the power of intelligent image acquisition with PreciScan for more efficient high-content imaging and analysis. This optional plug-in for Harmony high-content analysis software enables you to more accurately target your object of interest for significantly reduced acquisition and analysis times, particularly valuable for 3D microtissue and rare event studies.
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