PerkinElmer
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AngioSPARK 680 Fluorescent Imaging Agent

Near-infrared (NIR) fluorescent agent for in vivo imaging and other applications.

For laboratory use only. This product is intended for animal research only and not for use in humans.

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Overview

NanoSPARKS® are a family of highly fluorescent near infrared nanoparticles specifically designed for in vivo imaging. NanoSPARKS contain an iron oxide core that is coated to specifically produce a functionalized biocompatible product. AngioSPARK® 680 comprises pegylated fluorescent nanoparticles that remain localized in the vasculature for extended periods of time and enable imaging of blood vessels and angiogenesis. 

AngioSPARK 680 fluorescent imaging agent can also be used at later time points (>12 hours) to image vascular leak in tissue site of inflammation and cancer. AngioSPARK 680 can be imaged within the interstitium for up to 24 hours post tail vein injection.

Specifications

Fluorescent Agent Type Vascular
Optical Imaging Classification Fluorescence Imaging
Quantity in a Package Amount 1.0 Units
Shipping Condition Ambient
Therapeutic Area Vascular disease, Angiogenesis, Atherosclerosis, Arthritis, Inflammation, Oncology/Cancer
Unit Size 1 Vial (5 doses)
Wave Length 680 nm
Resources, Events & More
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Application Note

Vascular Imaging Probes For Oncology and Inflammation Using the IVIS Spectrum

Optical-based in vivo imaging of vascular changes and vascular leak is an emerging modality for studying altered physiology in a variety of different cancers and inflammatory states. A number of fluorescent imaging probes that circulate with the blood, but have no target selectivity, have been used to detect tumor leakiness as an indication of abnormal tumor vasculature. Inflammation is also characterized by distinct vascular changes, including vasodilation and increased vascular permeability, which are induced by the actions of various inflammatory mediators. This process is essential for facilitating access for appropriate cells, cytokines, and other factors to tissue sites in need of healing or protection from infection. This application note investigates the use of three fluorescent imaging probes, to detect and monitor vascular leak and inflammation in preclinical mouse breast cancer models.

PDF 4 MB

Ebook

In Vivo Imaging Solutions eBook

Researchers trust our in vivo imaging solutions to give them reliable, calibrated data that reveals pathway characterization and therapeutic efficacies for a broad range of indications. Our reagents, instruments, and applications support have helped hundreds of research projects over the years. And our hard-earned expertise makes us a trusted provider of pre-clinical imaging solutions— with more than 9,000 peer reviewed articles as proof.

PDF 4 MB

Flyer

Technical Note

AngioSPARK® 680 NanoSPARK™ (Data Sheet)

NanoSPARKS™ are a new family of highly fluorescent near infrared nanoparticles specifically designed for in vivo imaging. NanoSPARKS contain an iron oxide core that is coated to specifically produce a functionalized biocompatible product. AngioSPARK® 680 comprises pegylated fluorescent nanoparticles that remain localized in the vasculature for extended periods of time and enable imaging of blood vessels and angiogenesis.

PDF 53 KB

White Paper

The Role of In Vivo Imaging in Drug Discovery and Development

The primary goal of preclinical imaging is to improve the odds of clinical success and reduce drug discovery and development time and costs. Advances in non-invasive in vivo imaging techniques have raised the use of animal models in drug discovery and development to a new level by enabling quick and efficient drug screening and evaluation. Read this White Paper to learn how preclinical in vivo imaging helps to ensure that smart choices are made by providing Go/No-Go decisions and de-risking drug candidates early on, significantly reducing time to the clinic and lowering costs all while maximizing biological understanding.

PDF 748 KB