PerkinElmer

Receptor Ligand Binding

OF

A receptor ligand binding assay allows for the study and simple imaging of cell surface receptors for research and diagnostic applications. Receptor ligand binding is used in drug development applications to identify blocking antibodies or inhibitors that can modulate downstream signaling events, and is often used to screen for drugs that target hormone and neurotransmitter activity. We offer a range of tools for receptor ligand binding assays including radioligands, receptor-transfected cell membranes, and cell lines. Products available support both agonist and antagonist assays.

Our offerings include assays for:

  • Tyrosine kinase receptors
  • G-protein coupled receptors (GPCR)
  • Drug discovery and development
  • Ion channels
  • Protein analysis, detection, and interaction

Our collection of receptor ligand binding related assays includes fluorescence, LANCE® and DELFIA® time-resolved fluorescence, Alpha chemiluminescent assays, lites luminescence assays, and radiometric detection methods. Simplify the development of your assays and the calculation of your results using our radioligands, receptor-transfected cell membranes, and cell lines for receptor ligand binding applications.

  • Products and Services

  • Resources, Events & More

Narrow your results
Product Type
  • Consumables (2)
  • Instruments (7)
  • Reagents (540)
Application
  • cAMP (26)
  • Drug Discovery & Development (339)
  • Mobility Shift (36)
  • Molecular Biology (2)
  • Plant Sciences (1)
  • Protein Analysis & Detection (5)
  • Protein-protein interactions (4)
  • Radiometric (4)
Assay points(200-50,000)
  • 500 (2)
  • 5000 (2)
Assay Target Class
  • GPCR (181)
  • Ion channel (2)
  • Transporter (6)
  • Tyrosine Kinase Receptor (1)
Assay Validated
  • Binding (212)
  • Calcium Fluorescence (21)
  • Calcium Luminescence (4)
  • cAMP (56)
  • Downstream Phosphorylation (1)
  • GTPγS (54)
  • Inositol Phosphate (15)
Automation Compatible
  • No (20)
  • Yes (43)
Coating Treatment
  • Anti-mouse antibody (2)
  • Anti-mouse IgG (2)
  • Anti-rabbit antibody (2)
  • Anti-rabbit IgG (2)
  • Copper (HIS-tag) (2)
  • Copper chelate (2)
  • Glutathione (4)
  • HIS (2)
  • Nickel chelate (HIS-tag) (2)
  • PDE (2)
  • PEI (14)
  • Poly-L-lysine (2)
  • Poly-lysine (5)
  • Protein A (2)
  • RNA Binding (1)
  • Streptavidin (13)
  • Uncoated (1)
  • WGA (17)
  • WGA PEI type A (1)
  • WGA PEI Type B (1)
Color
  • White (4)
Concentration
  • 1 mCi/mL (4)
  • 1.0 - 10 mCi/mL (61)
  • 1.0 - 10 µCi/mL (3)
  • 1.0 mCi/mL (1)
  • 1.12 mCi/mL (1)
  • 1.14 mCi/mL (1)
  • 152 µCi/mL (1)
  • 170.1 µCi/mL (1)
  • 171 µCi/mL (1)
  • 172.5 µCi/mL (1)
  • 173.9 µCi/mL (1)
  • 182 µCi/mL (2)
  • 2 mCi/mL (1)
  • 2.93 MBq/mL (1)
  • 236 µCi (1)
  • 3.06 MBq/mL (1)
  • 3.22 MBq/mL (1)
  • 33.7 µCi (1)
  • 345 µCi/mL (3)
  • 353 µCi/mL (3)
  • 41.4 µCi/mL (2)
  • 42.5 µCi/mL (1)
  • 45.7 µCi/mL (1)
  • 50 µCi/mL (1)
  • 6.05 MBq/mL (1)
  • 79.2 µCi/mL (2)
  • 83.8 µCi/mL (1)
  • 85.1 µCi/mL (1)
  • 87.2 µCi/mL (1)
  • 87.4 µCi/mL (1)
  • 87.6 µCi/mL (1)
  • 87.9 µCi/mL (1)
  • 88.5 µCi/mL (1)
  • 93.2 µCi/mL (1)
  • <1.0 mCi/mL (7)
  • <1.0 µCi/mL (3)
  • <100 µCi/mL (1)
Detection Method
  • Alpha (3)
  • DELFIA TRF (4)
  • Filtration (4)
  • Fluorescence (1)
  • Radiometric (256)
  • Time-Resolved Fluorescence (TRF) (4)
Experimental Type
  • In vitro (4)
Fluorophore
  • Eu-N1-ITC (2)
Format
  • Microplates (19)
  • Tubes (11)
Host Cell
  • 1321N1 (12)
  • A431 (1)
  • A9 (1)
  • CHO-DHFR(-) (1)
  • CHO-K1 (134)
  • HEK293 (38)
  • HT29 (1)
  • K562 (1)
  • L Cells (1)
  • MDA-MB-435S (1)
  • MDCK (2)
  • U373 (1)
  • UC11 (1)
Label Position
  • Generally Labeled (6)
  • Nominally Labeled (98)
  • Specifically Labeled (96)
  • Uniformly Labeled (1)
Material
  • Barex/GF/B (1)
  • Barex/GF/C (1)
  • Polystyrene/GF/B (1)
  • Polystyrene/GF/C (1)
Number of Wells
  • 96 (4)
Product Brand Name
  • AequoScreen (1)
  • AequoZen (3)
  • AlphaLISA (3)
  • cAMPZen (1)
  • DELFIA (4)
  • LabChip EZ Reader (50)
  • Membrane Target Systems (114)
  • MicroBeta (2)
  • NEN Radiochemicals (120)
  • NEN Radiolabeled Ligands (76)
  • OmniFilter (1)
  • SPA Imaging Beads (18)
  • SPA Scintillation Beads (26)
  • UniFilter (7)
  • ValiScreen (75)
Radionuclide
  • 125I (78)
  • 14C (5)
  • 33P (2)
  • 35S (1)
  • 3H (1)
  • 3H (113)
Radioisotope
  • C-14 (6)
  • H-3 (114)
  • I-125 (78)
  • P-33 (2)
  • S-35 (1)
Receptor Type
  • 5-Hydroxytryptamine (12)
  • 5-Hydroxytryptamine (Serotonin) (23)
  • Acetylcholine (1)
  • Acetylcholine (Muscarinic) (16)
  • Adenosine (14)
  • Adrenergic (13)
  • Adrenoceptors (11)
  • Anaphylatoxin (4)
  • Angiotensin (9)
  • Apelin (2)
  • Benzodiazepine (6)
  • Bombesin (5)
  • Bradykinin (3)
  • Calcitonin (6)
  • Calcium (6)
  • Cannabinoid (8)
  • Chemokine (15)
  • Cholecystokinin (5)
  • Corticotropin-Releasing Factor (1)
  • Dopamine (20)
  • Dopamine Transporter (2)
  • Endothelin (3)
  • Epidermal Growth Factor (2)
  • Formyl Peptide (2)
  • Free Fatty Acid (2)
  • GABA (4)
  • GABAA (6)
  • GABAB (1)
  • Galanin (5)
  • Ghrelin (4)
  • Glucagon (7)
  • Glutamate (7)
  • Glycine (4)
  • Gonadotropin-releasing Hormone (1)
  • Growth Hormone (1)
  • hERG (3)
  • Histamine (10)
  • Insulin (3)
  • Insulin-like Growth Factor (1)
  • Interleukin (1)
  • Leukotriene (3)
  • Melanin-Concentrating Hormone (1)
  • Melanocortin (13)
  • Melatonin (2)
  • Metastin (1)
  • Motilin (1)
  • Muscarinic (10)
  • Neuromedin U (3)
  • Neuropeptide (7)
  • Neuropeptide Y (3)
  • Neurotensin (6)
  • Nicotinic (8)
  • NMDA (1)
  • Norephinephrine (1)
  • Norepinephrine (2)
  • Opioid (19)
  • Orexin (4)
  • Oxytocin (2)
  • Peptide P518 (1)
  • Platelet-Derived Growth Factor (1)
  • Potassium (2)
  • Progestin (1)
  • Prokineticin (1)
  • Prolactin Releasing Peptide (2)
  • Prostanoid (9)
  • Purinergic P2Y (2)
  • Relaxin (3)
  • Retinoic Acid Receptors (1)
  • Serotonin (4)
  • SK channels (1)
  • Sodium (1)
  • Somatostatin (11)
  • SVCT1 (1)
  • SVCT2 (1)
  • Tachykinin (7)
  • Thyroid Hormone (3)
  • Thyrotropin Releasing Hormone (1)
  • Thyrotropin-releasing Hormone (2)
  • Transforming Growth Factor (1)
  • TRPC5 (1)
  • Urotensin (2)
  • Vasoactive Intestinal Peptide (3)
  • Vasopressin (12)
  • Vesicular Amine Transporters (VATs) (1)
Sample Type
  • Enzyme (38)
Target Species
  • Human (10)
Therapeutic Area
  • Angiogenesis (27)
  • Biologics/Bioprocess (2)
  • Cancer (22)
  • Cardiovascular (119)
  • Central Nervous System (97)
  • CNS & Neurologic (126)
  • Diabetes (20)
  • Gastrointestinal (76)
  • Immune (3)
  • Inflammation (139)
  • Metabolic (53)
  • Metabolic Disorders (42)
  • Musculoskeletal (1)
  • Obesity (9)
  • Pain (72)
  • Parasympathetic Nervous System (5)
  • Renal (2)
  • Sympathetic Nervous System (2)
Volume
  • 0-50 (47)
  • 51-100 (2)
  • 201-250 (60)

"Receptor Ligand Binding" 1-50 of 549 Products and Services

Sort
Per Page
LabChip EZ Reader

EZ READER, SHIP LEVEL

The EZ Reader can help to save time and money in your laboratory by identifying the most promising lead candidates faster.

The EZ Reader instrument is available outside the EU. Please contact your local representative for further information.

UNIFILTER-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the Unifilter Harvester.

MICROBETA FILTERMAT-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the FilterMate Harvester. From beginning to end, the FilterMate system is easy to use.

MICROBETA FILTERMAT-24 CELL HARVESTER

Speed and simplicity are the primary strengths of the FilterMate Harvester. From beginning to end, the FilterMate system is easy to use. Need additional information? Click on the tabs in the product details section below.

UNIFILTER-96 CELL HARVESTER SS

Speed and simplicity are the primary strengths of the Unifilter Harvester.

UNIFILTER-24 CELL HARVESTER

Speed and simplicity are the primary strengths of the Unifilter Harvester.

OMNIFILTER-96 CELL HARVESTER

Speed and simplicity are the primary strengths of the OmniFilter Harvester.
PerkinElmer

Membrane Target Systems: Vasoactive Intestinal Polypeptide VIP membrane preparation

Cell membranes prepared from HT29 cells containing human endogenous Vasoactive Intestinal Polypeptide (VIP) receptor.
Receptor-expressing cell lines

ValiScreen Adenosine A3 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
Receptor-expressing cell lines

ValiScreen Neurotensin NTS1 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.

Norepinephrine, Levo-[ring-2,5,6-3H]

Levo-Norepinephrine, tritiated on the ring group. Norepinephrine binds and activates adrenergic receptors, and is cleared by the norepinehprine transporter (NET).
PerkinElmer

Polylysine YSI 1G

Poly-lysine-coated SPA beads, for use in proximity-based radiometric scintillation assays.

PDGF [125I] (human)

NEX433 [125I]-PDGF BB homodimer has been shown to work in RIA and receptor studies, using CHO cell line transfected with human PDGF B receptor, and human artery smooth muscle cells.

Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid (AMPA), DL-α-[5-Methyl-3H]

DL-α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid (AMPA), tritiated at the 5-methyl position. AMPA acts as an agonist at the AMPA receptor.

Vasopressin (8-L-Arginine), [Phenylalanyl-3,4,5-3H(N)]

Vasopressin, tritiated on the phenylalanine residue. Vasopressin binds and activates vasopressin receptors.
AlphaLISA immunoassay kits

FcγR3B (CD16b) AlphaLISA Binding Kit

The AlphaLISA FCGR3B (CD16b) binding kit is designed for the detection of binding between FcγR3B (CD16b) and human IgG Fc fragment using a homogeneous AlphaLISA assay (no wash steps). This assay can facilitate the design and development of antibody therapeutics using a competition assay format.

Paroxetine, [Phenyl-6'-3H]

Paroxetine (Paxil), tritiated at the phenyl-6' position. Paroxetine is a selective serotonin reuptake inhibitor (SSRI). This product has a scheduled lot release for the first Monday in May and November.

Lysergic Acid Diethylamide, [N-Methyl-3H]-, 250µCi (9.25MBq)

Lysergic Acid Diethylamide (LSD), tritiated on the N-methyl group. LSD is a partial agonist of dopamine D2 receptors. It also binds most serotonin receptors (5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT5A, 5-HT5B and 5-HT6). This product has a scheduled lot release for the second Monday in April, August and December.
Receptor-expressing cell lines

ValiScreen Chemokine CCR7 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
PerkinElmer

Membrane Target Systems: Neuropeptide NPFF2 (human) membrane preparation

Cell membranes prepared from cells stably-transfected with human Neuropeptide NPFF2 receptor, in CHO-K1 cells.

WAY100635, [METHOXY-3H], 250 uCi

WAY-100635, tritiated on the methoxy group. WAY-100635 acts as an antagonist at serotonin 5-HT1A receptors. It also acts as an agonist at dopamine D4 receptors.

Dihydroxyphenylethylamine, 3,4-[7-3H]

Dihydroxyphenylethylamine (dopamine, DA), tritiated at the 7 position. Dihydroxyphenylethylamine is a neurotransmitter and is the primary endogenous ligand for dopamine receptors. This product has a scheduled lot release for the second Monday in April and October.
Receptor-expressing cell lines

ValiScreen Cholecystokinin CCK1 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
PerkinElmer

Membrane Target Systems: Thromboxane TP (human) membrane preparation

Cell membranes prepared from cells stably-transfected with human Thromboxane TP receptor, in HEK-293 cells.

8-Hydroxy-DPAT, [Propyl-2,3-ring-1,2,3-3H]-

8-OH-DPAT radioligand tritiated at the 1,2,3 position on the propyl-2,3-ring. 8-OH-DPAT is a serotonin receptor agonist specific for the 5-HT1A and 5-HT7 receptors.
PerkinElmer

Streptavidin PVT 150MG

Streptavidin-coated SPA beads, for capturing biotinylated biomolecules in proximity-based radiometric scintillation assays.
PerkinElmer

ProfilerPro Kinase Peptide Substrate 6, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 6 for kinase assays (inhibiton, target discovery, lead optimization)
PerkinElmer

Membrane Target Systems: Muscarinic M1 (human) membrane preparation

Cell membranes prepared from cells stably-transfected with human Muscarinic M1 receptor, in CHO-K1 cells.

MIP-1α (human, recombinant), [125I]

Human recombinant macrophage inflammatory protein 1-alpha (MIP-1α; CCL3), labeled with 125I. MIP-1α is a cytokine involved in acute inflammation, and binds C-C chemokine receptors CCR1, CCR4, and CCR5.

Human IgG-conjugated AlphaLISA Acceptor Beads

AlphaLISA® Acceptor beads conjugated to human IgG (whole). These beads are intended for use in homogenous Alpha assays to capture Fc receptors.

Iodoantipyrine, 4-[N-Methyl-14C]

4-Iodoantipyrine, labeled with C-14 on the N-methyl group. Iodoantipyrine has been used to measure cerebral blood flow.
PerkinElmer

Membrane Target Systems: Somatostatin sst2a (human) membrane preparation, in CHO-K1 cells. 400 Units.

Our Membrane Target System membranes are prepared from cells that express recombinant or endogenous receptors. Selected for optimal performance in binding assays.

Hemicholinium-3 Diacetate Salt, [Methyl-3H]-, 250µCi (9.25MBq)

Hemicholinium-3 (HC3; hemicholine) Diacetate Salt, tritiated on the methyl group. Hemicholinium-3 blocks reuptake of choline by the high-affinity choline transporter. This product has a scheduled lot release for the second Monday in February and August.

Thyroxine, ([125I]-T4), Specific Activity: 1080-1320 µCi/µg

Thyroxine (T4) labeled with 125I. Thyroxine is a thyroid hormone that is responsible for regulation or metabolism. T4 detection by radioimmunoassay is a common test of thyroid disease. This product is offered at three specific activities. Specific activity indicates how much radioactivity there is per molecule of thyroxine. Several of our 125I-labeled ligands are offered at maximum specific activity (2200 Ci/mmol if one 125I labeling site is available, 4400 Ci/mmol if two labeling sites are available).
Receptor-expressing cell lines

ValiScreen Muscarinic M4 (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.

SCH 23390, [N-Methyl-3H]

SCH-23390 (halobenzazepine), tritiated on the N-methyl group. SCH-23390 acts as an antagonist at the dopamine D1 receptor.
PerkinElmer

Membrane Target Systems: Serotonin 5HT6 (rat) membrane preparation

Cell membranes prepared from cells stably-transfected with rat Serotonin 5-HT6 receptor, in HEK-293 cells.
PerkinElmer

Streptavidin PS 2G Imaging Beads

Streptavidin-coated SPA beads, for capturing biotinylated molecules in proximity-based scintillation assays.

Hydroxytryptamine Binoxalate (Serotonin Binoxalate), 5-[1-14C]

5-Hydroxytryptamine Binoxalate (Serotonin Binoxalate), labeled with C-14 at the 1-position. 5-Hydroxytryptamine is a neurotransmitter and is the endogenous ligand for serotonin receptors. NEC855 replaces product NEC225, which was labeled at the 2-position.

Peptide YY (Human), ([125I]-PYY)

Peptide YY, labeled with 125I. Peptide YY acts as a neuropeptide Y receptor Y2 agonist, is released in response to feeding, and is associated with appetite saiety.

(+)-Pentazocine, [Ring-1,3-3H]

(+)-Pentazocine radioligand tritiated at the 1,3 position on the ring. Pentazocine is a synthetic opioid shown to bind sigma 1 receptor.
Receptor-expressing cell lines

ValiScreen TRH (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
PerkinElmer

WGA PS 2G Imaging Bead

WGA-coated SPA beads, for capturing cell membranes in proximity-based scintillation assays.
Receptor-expressing cell lines

ValiScreen Chemotactic Peptide C5a (human) cell line

Our stable recombinant ValiScreen cell lines express a variety of GPCRs for binding and functional assays.
PerkinElmer

Membrane Target Systems: Adenosine A1 (rat) membrane preparation, in CHO-K1 cells. 400 Units.

Cell membranes prepared from CHO-K1 cells stably-transfected with rat adenosine A1 receptor, 400 units.
PerkinElmer

Membrane Target Systems: Cannabinoid CB2 (human) membrane preparation

Cell membranes prepared from cells stably-transfected with human Cannabinoid CB2 receptor, in HEK-293 cells.
PerkinElmer

Streptavidin PVT 2G

Streptavidin-coated SPA beads, for capturing biotinylated biomolecules in proximity-based radiometric scintillation assays.
PerkinElmer

PDE YSI 2G

SPA (scintillation proximity assay) beads designed for the capture of [3H]AMP or [3H]GMP on specially prepared yttrium silicate beads.
PerkinElmer

Membrane Target Systems: Serotonin 5HT1a (human) membrane preparation, in CHO-K1 cells. 400 Units.

Cell membranes prepared from cells stably-transfected with human serotonin 5HT1a receptor
PerkinElmer

ProfilerPro Kinase Peptide Substrate 7, for LabChip EZ Reader

Fluorescently-labelled peptide substrate 7 for kinase assays (inhibiton, target discovery, lead optimization)

"Receptor Ligand Binding" 1-50 of 549 Products and Services

Per Page